BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

99 related articles for article (PubMed ID: 18557608)

  • 1. Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
    Mahaney PE; Gavrin LK; Trybulski EJ; Stack GP; Vu TA; Cohn ST; Ye F; Belardi JK; Santilli AA; Sabatucci JP; Leiter J; Johnston GH; Bray JA; Burroughs KD; Cosmi SA; Leventhal L; Koury EJ; Zhang Y; Mugford CA; Ho DM; Rosenzweig-Lipson SJ; Platt B; Smith VA; Deecher DC
    J Med Chem; 2008 Jul; 51(13):4038-49. PubMed ID: 18557608
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
    Sabatucci JP; Mahaney PE; Leiter J; Johnston G; Burroughs K; Cosmi S; Zhang Y; Ho D; Deecher DC; Trybulski E
    Bioorg Med Chem Lett; 2010 May; 20(9):2809-12. PubMed ID: 20378347
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
    Vu AT; Cohn ST; Zhang P; Kim CY; Mahaney PE; Bray JA; Johnston GH; Koury EJ; Cosmi SA; Deecher DC; Smith VA; Harrison JE; Leventhal L; Whiteside GT; Kennedy JD; Trybulski EJ
    J Med Chem; 2010 Mar; 53(5):2051-62. PubMed ID: 20131864
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
    Zhang P; Terefenko EA; Bray J; Deecher D; Fensome A; Harrison J; Kim C; Koury E; Mark L; McComas CC; Mugford CA; Trybulski EJ; Vu AT; Whiteside GT; Mahaney PE
    J Med Chem; 2009 Sep; 52(18):5703-11. PubMed ID: 19722525
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
    O'Neill DJ; Adedoyin A; Alfinito PD; Bray JA; Cosmi S; Deecher DC; Fensome A; Harrison J; Leventhal L; Mann C; McComas CC; Sullivan NR; Spangler TB; Uveges AJ; Trybulski EJ; Whiteside GT; Zhang P
    J Med Chem; 2010 Jun; 53(11):4511-21. PubMed ID: 20462211
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
    Fensome A; Goldberg J; McComas CC; Trybulski EJ; Woodworth RP; Deecher DC; Whiteside GT; Zhang P
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1555-8. PubMed ID: 20153188
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
    Kim CY; Mahaney PE; McConnell O; Zhang Y; Manas E; Ho DM; Deecher DC; Trybulski EJ
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5029-32. PubMed ID: 19632110
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
    Hudson S; Kiankarimi M; Eccles W; Dwight W; Mostofi YS; Genicot MJ; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4491-4. PubMed ID: 18672364
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
    Wu D; Pontillo J; Ching B; Hudson S; Gao Y; Fleck BA; Gogas K; Wade WS
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4224-7. PubMed ID: 18550369
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
    McComas CC; Vu AT; Mahaney PE; Cohn ST; Fensome A; Marella MA; Nogle L; Trybulski EJ; Ye F; Zhang P; Alfinito P; Bray J; Johnston G; Koury E; Deecher DC
    Bioorg Med Chem Lett; 2008 Sep; 18(18):4929-31. PubMed ID: 18771916
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
    Micheli F; Cavanni P; Andreotti D; Arban R; Benedetti R; Bertani B; Bettati M; Bettelini L; Bonanomi G; Braggio S; Carletti R; Checchia A; Corsi M; Fazzolari E; Fontana S; Marchioro C; Merlo-Pich E; Negri M; Oliosi B; Ratti E; Read KD; Roscic M; Sartori I; Spada S; Tedesco G; Tarsi L; Terreni S; Visentini F; Zocchi A; Zonzini L; Di Fabio R
    J Med Chem; 2010 Jul; 53(13):4989-5001. PubMed ID: 20527970
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors.
    Xu W; Gray DL; Glase SA; Barta NS
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5550-3. PubMed ID: 18805691
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.
    Pontillo J; Wu D; Ching B; Hudson S; Genicot MJ; Gao Y; Ewing T; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6151-5. PubMed ID: 18954981
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
    Shimada I; Maeno K; Kazuta K; Kubota H; Kimizuka T; Kimura Y; Hatanaka K; Naitou Y; Wanibuchi F; Sakamoto S; Tsukamoto S
    Bioorg Med Chem; 2008 Feb; 16(4):1966-82. PubMed ID: 18035544
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.
    Shao L; Hewitt MC; Wang F; Malcolm SC; Ma J; Campbell JE; Campbell UC; Engel SR; Spicer NA; Hardy LW; Schreiber R; Spear KL; Varney MA
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1434-7. PubMed ID: 21310612
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
    Fish PV; Wakenhut F; Ryckmans T; Stobie A
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4579-83. PubMed ID: 19616432
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol.
    Patrick KS; Williard RL; VanWert AL; Dowd JJ; Oatis JE; Middaugh LD
    J Med Chem; 2005 Apr; 48(8):2876-81. PubMed ID: 15828826
    [TBL] [Abstract][Full Text] [Related]  

  • 18. BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
    Clarke B; Demont E; Dingwall C; Dunsdon R; Faller A; Hawkins J; Hussain I; MacPherson D; Maile G; Matico R; Milner P; Mosley J; Naylor A; O'Brien A; Redshaw S; Riddell D; Rowland P; Soleil V; Smith KJ; Stanway S; Stemp G; Sweitzer S; Theobald P; Vesey D; Walter DS; Ward J; Wayne G
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1017-21. PubMed ID: 18166458
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants.
    Zhou J; Kläss T; Johnson KM; Giberson KM; Kozikowski AP
    Bioorg Med Chem Lett; 2005 May; 15(10):2461-5. PubMed ID: 15863297
    [TBL] [Abstract][Full Text] [Related]  

  • 20. BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
    Clarke B; Demont E; Dingwall C; Dunsdon R; Faller A; Hawkins J; Hussain I; MacPherson D; Maile G; Matico R; Milner P; Mosley J; Naylor A; O'Brien A; Redshaw S; Riddell D; Rowland P; Soleil V; Smith KJ; Stanway S; Stemp G; Sweitzer S; Theobald P; Vesey D; Walter DS; Ward J; Wayne G
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1011-6. PubMed ID: 18171614
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.