BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

228 related articles for article (PubMed ID: 18564357)

  • 1. High expression of the cGMP-specific phosphodiesterase, PDE9A, in sickle cell disease (SCD) and the effects of its inhibition in erythroid cells and SCD neutrophils.
    Almeida CB; Traina F; Lanaro C; Canalli AA; Saad ST; Costa FF; Conran N
    Br J Haematol; 2008 Sep; 142(5):836-44. PubMed ID: 18564357
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
    Kleiman RJ; Chapin DS; Christoffersen C; Freeman J; Fonseca KR; Geoghegan KF; Grimwood S; Guanowsky V; Hajós M; Harms JF; Helal CJ; Hoffmann WE; Kocan GP; Majchrzak MJ; McGinnis D; McLean S; Menniti FS; Nelson F; Roof R; Schmidt AW; Seymour PA; Stephenson DT; Tingley FD; Vanase-Frawley M; Verhoest PR; Schmidt CJ
    J Pharmacol Exp Ther; 2012 May; 341(2):396-409. PubMed ID: 22328573
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice.
    Almeida CB; Scheiermann C; Jang JE; Prophete C; Costa FF; Conran N; Frenette PS
    Blood; 2012 Oct; 120(14):2879-88. PubMed ID: 22833547
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.
    Wang P; Wu P; Egan RW; Billah MM
    Gene; 2003 Sep; 314():15-27. PubMed ID: 14527714
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation.
    Canalli AA; Franco-Penteado CF; Saad ST; Conran N; Costa FF
    Haematologica; 2008 Apr; 93(4):605-9. PubMed ID: 18326523
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy.
    Iyamu EW; Cecil R; Parkin L; Woods G; Ohene-Frempong K; Asakura T
    Br J Haematol; 2005 Nov; 131(3):389-94. PubMed ID: 16225659
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role for cAMP-protein kinase A signalling in augmented neutrophil adhesion and chemotaxis in sickle cell disease.
    Canalli AA; Franco-Penteado CF; Traina F; Saad ST; Costa FF; Conran N
    Eur J Haematol; 2007 Oct; 79(4):330-7. PubMed ID: 17680813
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties.
    Gambero S; Canalli AA; Traina F; Albuquerque DM; Saad ST; Costa FF; Conran N
    Eur J Haematol; 2007 Feb; 78(2):144-51. PubMed ID: 17313560
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients.
    Conran N; Almeida CB; Lanaro C; Ferreira RP; Traina F; Saad ST; Costa FF
    Br J Haematol; 2007 Oct; 139(1):148-58. PubMed ID: 17711515
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy.
    Lanaro C; Franco-Penteado CF; Albuqueque DM; Saad ST; Conran N; Costa FF
    J Leukoc Biol; 2009 Feb; 85(2):235-42. PubMed ID: 19004988
    [TBL] [Abstract][Full Text] [Related]  

  • 11. [Modern representations of multiple forms of cyclic nucleotide phosphodiesterases in mammalian tissues].
    Medvedeva MV
    Biokhimiia; 1995 Mar; 60(3):364-86. PubMed ID: 7734612
    [TBL] [Abstract][Full Text] [Related]  

  • 12. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling.
    Wang PX; Li ZM; Cai SD; Li JY; He P; Huang Y; Feng GS; Luo HB; Chen SR; Liu PQ
    Acta Pharmacol Sin; 2017 Sep; 38(9):1257-1268. PubMed ID: 28649129
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dual roles of PDE9a in meiotic maturation of zebrafish oocytes.
    Li J; Bai L; Liu Z; Wang W
    Biochem Biophys Res Commun; 2020 Oct; 532(1):40-46. PubMed ID: 32826058
    [TBL] [Abstract][Full Text] [Related]  

  • 14. [Phosphodiesterases of cyclic GMP].
    Wróblewska H; Gorczyca WA
    Postepy Hig Med Dosw; 2001; 55(5):611-27. PubMed ID: 11795198
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphodiesterase 9: insights from protein structure and role in therapeutics.
    Singh N; Patra S
    Life Sci; 2014 Jun; 106(1-2):1-11. PubMed ID: 24746902
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypertrophied right hearts get two for the price of one: can inhibiting phosphodiesterase type 5 also inhibit phosphodiesterase type 3?
    Kass DA
    Circulation; 2007 Jul; 116(3):233-5. PubMed ID: 17638937
    [No Abstract]   [Full Text] [Related]  

  • 17. Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.
    Miguel LI; Almeida CB; Traina F; Canalli AA; Dominical VM; Saad ST; Costa FF; Conran N
    Inflamm Res; 2011 Jul; 60(7):633-42. PubMed ID: 21336703
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.
    Rosenbrock H; Giovannini R; Schänzle G; Koros E; Runge F; Fuchs H; Marti A; Reymann KG; Schröder UH; Fedele E; Dorner-Ciossek C
    J Pharmacol Exp Ther; 2019 Dec; 371(3):633-641. PubMed ID: 31578258
    [No Abstract]   [Full Text] [Related]  

  • 19. Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients.
    Conran N; Oresco-Santos C; Acosta HC; Fattori A; Saad ST; Costa FF
    Br J Haematol; 2004 Feb; 124(4):547-54. PubMed ID: 14984506
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.
    Kroker KS; Mathis C; Marti A; Cassel JC; Rosenbrock H; Dorner-Ciossek C
    Neurobiol Aging; 2014 Sep; 35(9):2072-8. PubMed ID: 24746365
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.