Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

206 related articles for article (PubMed ID: 18566221)

  • 1. Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines.
    Wangpaichitr M; Savaraj N; Maher J; Kurtoglu M; Lampidis TJ
    Mol Cancer Ther; 2008 Jun; 7(6):1506-13. PubMed ID: 18566221
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway.
    Pore N; Jiang Z; Shu HK; Bernhard E; Kao GD; Maity A
    Mol Cancer Res; 2006 Jul; 4(7):471-9. PubMed ID: 16849522
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma.
    Zhou L; Zhao Y; Pan LC; Wang J; Shi XJ; Du GS; He Q
    World J Gastroenterol; 2022 Aug; 28(32):4600-4619. PubMed ID: 36157928
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells.
    Huang J; Gao L; Li B; Liu C; Hong S; Min J; Hong L
    Med Sci Monit; 2019 Jun; 25():4250-4263. PubMed ID: 31175269
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway.
    Gong T; Cui L; Wang H; Wang H; Han N
    J Transl Med; 2018 Jun; 16(1):164. PubMed ID: 29898734
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
    Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT
    Mol Cell Biol; 2002 Oct; 22(20):7004-14. PubMed ID: 12242281
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors.
    Harada H; Itasaka S; Kizaka-Kondoh S; Shibuya K; Morinibu A; Shinomiya K; Hiraoka M
    J Biol Chem; 2009 Feb; 284(8):5332-42. PubMed ID: 19098000
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Suppression of the proliferation of hypoxia-Induced retinal pigment epithelial cell by rapamycin through the /mTOR/HIF-1α/VEGF/ signaling.
    Liu NN; Zhao N; Cai N
    IUBMB Life; 2015 Jun; 67(6):446-52. PubMed ID: 25988388
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activation of HIF-1alpha in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway.
    Dayan F; Bilton RL; Laferrière J; Trottier E; Roux D; Pouyssegur J; Mazure NM
    J Cell Physiol; 2009 Jan; 218(1):167-74. PubMed ID: 18781596
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rapid non-genomic signalling by 17β-oestradiol through c-Src involves mTOR-dependent expression of HIF-1α in breast cancer cells.
    Sudhagar S; Sathya S; Lakshmi BS
    Br J Cancer; 2011 Sep; 105(7):953-60. PubMed ID: 21897387
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition.
    Jampasri S; Reabroi S; Tungmunnithum D; Parichatikanond W; Pinthong D
    Molecules; 2022 Sep; 27(17):. PubMed ID: 36080483
    [TBL] [Abstract][Full Text] [Related]  

  • 12. mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.
    Matsumoto K; Arao T; Tanaka K; Kaneda H; Kudo K; Fujita Y; Tamura D; Aomatsu K; Tamura T; Yamada Y; Saijo N; Nishio K
    Cancer Res; 2009 Sep; 69(18):7160-4. PubMed ID: 19738050
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose.
    Maher JC; Wangpaichitr M; Savaraj N; Kurtoglu M; Lampidis TJ
    Mol Cancer Ther; 2007 Feb; 6(2):732-41. PubMed ID: 17308069
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif.
    Land SC; Tee AR
    J Biol Chem; 2007 Jul; 282(28):20534-43. PubMed ID: 17502379
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of rapamycin in human placental BeWo cells under hypoxia.
    Zhou F; Guan LB; Yu P; Wang XD; Hu YY
    Placenta; 2016 Sep; 45():24-31. PubMed ID: 27577706
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/hypoxia-inducible factor-1alpha axis.
    Pencreach E; Guérin E; Nicolet C; Lelong-Rebel I; Voegeli AC; Oudet P; Larsen AK; Gaub MP; Guenot D
    Clin Cancer Res; 2009 Feb; 15(4):1297-307. PubMed ID: 19190131
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment.
    Frolova O; Samudio I; Benito JM; Jacamo R; Kornblau SM; Markovic A; Schober W; Lu H; Qiu YH; Buglio D; McQueen T; Pierce S; Shpall E; Konoplev S; Thomas D; Kantarjian H; Lock R; Andreeff M; Konopleva M
    Cancer Biol Ther; 2012 Aug; 13(10):858-70. PubMed ID: 22785211
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.
    Ushijima H; Suzuki Y; Oike T; Komachi M; Yoshimoto Y; Ando K; Okonogi N; Sato H; Noda SE; Saito J; Nakano T
    J Radiat Res; 2015 Jul; 56(4):663-8. PubMed ID: 25887043
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells.
    Kim H; Na YR; Kim SY; Yang EG
    J Cell Biochem; 2016 Mar; 117(3):647-58. PubMed ID: 26284819
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells.
    Xiao H; Li S; Zhang D; Liu T; Yu M; Wang F
    Oncol Rep; 2013 Jan; 29(1):329-34. PubMed ID: 23076497
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.