179 related articles for article (PubMed ID: 18572901)
1. Activation mechanism of the human histamine H4 receptor--an explicit membrane molecular dynamics simulation study.
Jójárt B; Kiss R; Viskolcz B; Keseru GM
J Chem Inf Model; 2008 Jun; 48(6):1199-210. PubMed ID: 18572901
[TBL] [Abstract][Full Text] [Related]
2. Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor.
Kiss R; Noszál B; Rácz A; Falus A; Eros D; Keseru GM
Eur J Med Chem; 2008 May; 43(5):1059-70. PubMed ID: 17900762
[TBL] [Abstract][Full Text] [Related]
3. Sequential application of ligand and structure based modeling approaches to index chemicals for their hH4R antagonism.
Pappalardo M; Shachaf N; Basile L; Milardi D; Zeidan M; Raiyn J; Guccione S; Rayan A
PLoS One; 2014; 9(10):e109340. PubMed ID: 25330207
[TBL] [Abstract][Full Text] [Related]
4. The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.
Wifling D; Bernhardt G; Dove S; Buschauer A
PLoS One; 2015; 10(1):e0117185. PubMed ID: 25629160
[TBL] [Abstract][Full Text] [Related]
5. Binding pathway of histamine to the hH4R, observed by unconstrained molecular dynamics.
Wittmann HJ; Strasser A
Bioorg Med Chem Lett; 2015 Mar; 25(6):1259-68. PubMed ID: 25677665
[TBL] [Abstract][Full Text] [Related]
6. Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity.
Seifert R; Schneider EH; Dove S; Brunskole I; Neumann D; Strasser A; Buschauer A
Mol Pharmacol; 2011 Apr; 79(4):631-8. PubMed ID: 21266488
[TBL] [Abstract][Full Text] [Related]
7. Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
Kiss R; Kiss B; Könczöl A; Szalai F; Jelinek I; László V; Noszál B; Falus A; Keseru GM
J Med Chem; 2008 Jun; 51(11):3145-53. PubMed ID: 18459760
[TBL] [Abstract][Full Text] [Related]
8. Sodium binding to hH3R and hH 4R--a molecular modeling study.
Wittmann HJ; Seifert R; Strasser A
J Mol Model; 2014 Aug; 20(8):2394. PubMed ID: 25098339
[TBL] [Abstract][Full Text] [Related]
9. Docking and MD study of histamine H4R based on the crystal structure of H1R.
Feng Z; Hou T; Li Y
J Mol Graph Model; 2013 Feb; 39():1-12. PubMed ID: 23220277
[TBL] [Abstract][Full Text] [Related]
10. A bioinformatics search for selective histamine h4 receptor antagonists through structure-based virtual screening strategies.
Christopher F; Thangam EB; Suresh MX
Chem Biol Drug Des; 2012 May; 79(5):749-59. PubMed ID: 22260722
[TBL] [Abstract][Full Text] [Related]
11. 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity.
Hammer SG; Gobleder S; Naporra F; Wittmann HJ; Elz S; Heinrich MR; Strasser A
Bioorg Med Chem Lett; 2016 Jan; 26(2):292-300. PubMed ID: 26718844
[TBL] [Abstract][Full Text] [Related]
12. Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor.
Schneider EH; Schnell D; Strasser A; Dove S; Seifert R
J Pharmacol Exp Ther; 2010 May; 333(2):382-92. PubMed ID: 20106995
[TBL] [Abstract][Full Text] [Related]
13. The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva.
Zampeli E; Thurmond RL; Tiligada E
Inflamm Res; 2009 Jun; 58(6):285-91. PubMed ID: 19184344
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists.
Igel P; Geyer R; Strasser A; Dove S; Seifert R; Buschauer A
J Med Chem; 2009 Oct; 52(20):6297-313. PubMed ID: 19791743
[TBL] [Abstract][Full Text] [Related]
15. Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations.
Reher TM; Neumann D; Buschauer A; Seifert R
Biochem Pharmacol; 2012 Jul; 84(2):192-203. PubMed ID: 22516788
[TBL] [Abstract][Full Text] [Related]
16. Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo.
Ehling S; Roßbach K; Dunston SM; Stark H; Bäumer W
J Dermatol Sci; 2016 Aug; 83(2):106-15. PubMed ID: 27155791
[TBL] [Abstract][Full Text] [Related]
17. Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists.
Geyer R; Nordemann U; Strasser A; Wittmann HJ; Buschauer A
J Med Chem; 2016 Apr; 59(7):3452-70. PubMed ID: 27007611
[TBL] [Abstract][Full Text] [Related]
18. Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants.
Wifling D; Löffel K; Nordemann U; Strasser A; Bernhardt G; Dove S; Seifert R; Buschauer A
Br J Pharmacol; 2015 Feb; 172(3):785-98. PubMed ID: 24903527
[TBL] [Abstract][Full Text] [Related]
19. Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor--H1/H4 receptor selectivity.
Wagner E; Wittmann HJ; Elz S; Strasser A
Naunyn Schmiedebergs Arch Pharmacol; 2014 Mar; 387(3):235-50. PubMed ID: 24241585
[TBL] [Abstract][Full Text] [Related]
20. Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.
Lee-Dutra A; Arienti KL; Buzard DJ; Hack MD; Khatuya H; Desai PJ; Nguyen S; Thurmond RL; Karlsson L; Edwards JP; Breitenbucher JG
Bioorg Med Chem Lett; 2006 Dec; 16(23):6043-8. PubMed ID: 16990005
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
