These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 18582445)

  • 1. Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog.
    Studzinski CM; MacKay WA; Beckett TL; Henderson ST; Murphy MP; Sullivan PG; Burnham WM
    Brain Res; 2008 Aug; 1226():209-17. PubMed ID: 18582445
    [TBL] [Abstract][Full Text] [Related]  

  • 2. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
    J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
    [TBL] [Abstract][Full Text] [Related]  

  • 3. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
    Lin HC; Hsieh HM; Chen YH; Hu ML
    Neurotoxicology; 2009 Jul; 30(4):622-7. PubMed ID: 19635394
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease.
    Borghi R; Patriarca S; Traverso N; Piccini A; Storace D; Garuti A; Gabriella Cirmena ; Patrizio Odetti ; Massimo Tabaton
    Neurobiol Aging; 2007 Jul; 28(7):1009-14. PubMed ID: 16769154
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.
    Hampel H; Shen Y
    Scand J Clin Lab Invest; 2009; 69(1):8-12. PubMed ID: 18609117
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression.
    Quiroz-Baez R; Rojas E; Arias C
    Neurochem Int; 2009 Dec; 55(7):662-70. PubMed ID: 19560504
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
    Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
    Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice.
    Hauptmann S; Scherping I; Dröse S; Brandt U; Schulz KL; Jendrach M; Leuner K; Eckert A; Müller WE
    Neurobiol Aging; 2009 Oct; 30(10):1574-86. PubMed ID: 18295378
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons.
    Patil S; Sheng L; Masserang A; Chan C
    Neurosci Lett; 2006 Oct; 406(1-2):55-9. PubMed ID: 16904262
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
    Volbracht C; Penzkofer S; Mansson D; Christensen KV; Fog K; Schildknecht S; Leist M; Nielsen J
    Anal Biochem; 2009 Apr; 387(2):208-20. PubMed ID: 19454261
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.
    Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K
    Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease.
    Reddy PH
    J Neurochem; 2006 Jan; 96(1):1-13. PubMed ID: 16305625
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The effect of oxidative stress on amyloid precursor protein processing in cells engaged in beta-amyloidosis is related to apolipoprotein E genotype.
    Mazur-Kolecka B; Kowal D; Sukontasup T; Dickson D; Frackowiak J
    Acta Neuropathol; 2004 Oct; 108(4):287-94. PubMed ID: 15221339
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice.
    Tong XK; Nicolakakis N; Fernandes P; Ongali B; Brouillette J; Quirion R; Hamel E
    Neurobiol Dis; 2009 Sep; 35(3):406-14. PubMed ID: 19524673
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Update on amyloid-beta homeostasis markers for sporadic Alzheimer's disease.
    Zetterberg H
    Scand J Clin Lab Invest; 2009; 69(1):18-21. PubMed ID: 19199126
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B; Pereira I; Parkin E
    Brain Res; 2009 Nov; 1296():203-15. PubMed ID: 19679113
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M
    J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.
    Shimazawa M; Inokuchi Y; Okuno T; Nakajima Y; Sakaguchi G; Kato A; Oku H; Sugiyama T; Kudo T; Ikeda T; Takeda M; Hara H
    J Neurochem; 2008 Oct; 107(1):279-90. PubMed ID: 18691390
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intraneuronal amyloid precursor protein (APP) and appearance of extracellular beta-amyloid peptide (abeta) in the brain of aging kokanee salmon.
    Maldonado TA; Jones RE; Norris DO
    J Neurobiol; 2002 Oct; 53(1):11-20. PubMed ID: 12360579
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.