547 related articles for article (PubMed ID: 18591981)
41. Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle.
Zhang C; Liu F; Zhang Y; Song C
Eur J Med Chem; 2024 Mar; 268():116234. PubMed ID: 38401189
[TBL] [Abstract][Full Text] [Related]
42. Lead discovery and optimization strategies for peptide macrocycles.
Bhat A; Roberts LR; Dwyer JJ
Eur J Med Chem; 2015 Apr; 94():471-9. PubMed ID: 25109255
[TBL] [Abstract][Full Text] [Related]
43. Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
Marsault E; Peterson ML
J Med Chem; 2011 Apr; 54(7):1961-2004. PubMed ID: 21381769
[No Abstract] [Full Text] [Related]
44. Structural and conformational determinants of macrocycle cell permeability.
Over B; Matsson P; Tyrchan C; Artursson P; Doak BC; Foley MA; Hilgendorf C; Johnston SE; Lee MD; Lewis RJ; McCarren P; Muncipinto G; Norinder U; Perry MW; Duvall JR; Kihlberg J
Nat Chem Biol; 2016 Dec; 12(12):1065-1074. PubMed ID: 27748751
[TBL] [Abstract][Full Text] [Related]
45. Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.
Galliford CV; Scheidt KA
Angew Chem Int Ed Engl; 2007; 46(46):8748-58. PubMed ID: 17943924
[TBL] [Abstract][Full Text] [Related]
46. Natural products as a robust source of new drugs and drug leads: past successes and present day issues.
Rishton GM
Am J Cardiol; 2008 May; 101(10A):43D-49D. PubMed ID: 18474274
[TBL] [Abstract][Full Text] [Related]
47. Synthetic analogs of natural glycosides in drug discovery and development.
Grynkiewicz G; Szeja W; Boryski J
Acta Pol Pharm; 2008; 65(6):655-76. PubMed ID: 19172847
[TBL] [Abstract][Full Text] [Related]
48. Macrocyclizations for medicinal chemistry: synthesis of druglike macrocycles by high-concentration Ullmann coupling.
Collins JC; Farley KA; Limberakis C; Liras S; Price D; James K
J Org Chem; 2012 Dec; 77(24):11079-90. PubMed ID: 23167628
[TBL] [Abstract][Full Text] [Related]
49. Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?
Giordanetto F; Kihlberg J
J Med Chem; 2014 Jan; 57(2):278-95. PubMed ID: 24044773
[TBL] [Abstract][Full Text] [Related]
50. Physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde.
Reddy PM; Ho YP; Shanker K; Rohini R; Ravinder V
Eur J Med Chem; 2009 Jun; 44(6):2621-5. PubMed ID: 18996622
[TBL] [Abstract][Full Text] [Related]
51. Exploring the synthetic approaches and clinical prowess of established macrocyclic pharmaceuticals.
Sun JG; Nie P; Herdewijn P; Li XJ
Eur J Med Chem; 2024 Jan; 264():116051. PubMed ID: 38104377
[TBL] [Abstract][Full Text] [Related]
52. Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp(3)-rich library.
Storr TE; Cully SJ; Rawling MJ; Lewis W; Hamza D; Jones G; Stockman RA
Bioorg Med Chem; 2015 Jun; 23(11):2621-8. PubMed ID: 25638497
[TBL] [Abstract][Full Text] [Related]
53. Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.
Amrhein JA; Knapp S; Hanke T
J Med Chem; 2021 Jun; 64(12):7991-8009. PubMed ID: 34076436
[TBL] [Abstract][Full Text] [Related]
54. Horses for courses: reaching outside drug-like chemical space for inhibitors of challenging drug targets.
Whitty A; Zhou L
Future Med Chem; 2015; 7(9):1093-5. PubMed ID: 26132520
[No Abstract] [Full Text] [Related]
55. Synthetic studies of heterocyclic natural products.
JoulliƩ MM; Berritt S; Forbeck EM
Curr Opin Drug Discov Devel; 2008 Nov; 11(6):829-52. PubMed ID: 18946847
[TBL] [Abstract][Full Text] [Related]
56. Acid promoted cinnamyl ion mobility within peptide derived macrocycles.
Zhao H; Negash L; Wei Q; LaCour TG; Estill SJ; Capota E; Pieper AA; Harran PG
J Am Chem Soc; 2008 Oct; 130(42):13864-6. PubMed ID: 18811162
[TBL] [Abstract][Full Text] [Related]
57. The emerging role of computational design in peptide macrocycle drug discovery.
Mulligan VK
Expert Opin Drug Discov; 2020 Jul; 15(7):833-852. PubMed ID: 32345066
[TBL] [Abstract][Full Text] [Related]
58. Macrocycles as protein-protein interaction inhibitors.
Dougherty PG; Qian Z; Pei D
Biochem J; 2017 Mar; 474(7):1109-1125. PubMed ID: 28298556
[TBL] [Abstract][Full Text] [Related]
59. Dihedral Angle-Based Sampling of Natural Product Polyketide Conformations: Application to Permeability Prediction.
Wang Q; Sciabola S; Barreiro G; Hou X; Bai G; Shapiro MJ; Koehn F; Villalobos A; Jacobson MP
J Chem Inf Model; 2016 Nov; 56(11):2194-2206. PubMed ID: 27731994
[TBL] [Abstract][Full Text] [Related]
60. Enantiospecific total syntheses of kapakahines B and F.
Newhouse T; Lewis CA; Baran PS
J Am Chem Soc; 2009 May; 131(18):6360-1. PubMed ID: 19374357
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]