BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

244 related articles for article (PubMed ID: 18596239)

  • 1. WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.
    Cheng WH; Muftic D; Muftuoglu M; Dawut L; Morris C; Helleday T; Shiloh Y; Bohr VA
    Mol Biol Cell; 2008 Sep; 19(9):3923-33. PubMed ID: 18596239
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
    Ammazzalorso F; Pirzio LM; Bignami M; Franchitto A; Pichierri P
    EMBO J; 2010 Sep; 29(18):3156-69. PubMed ID: 20802463
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.
    Pichierri P; Rosselli F; Franchitto A
    Oncogene; 2003 Mar; 22(10):1491-500. PubMed ID: 12629512
    [TBL] [Abstract][Full Text] [Related]  

  • 4. WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.
    Patro BS; Frøhlich R; Bohr VA; Stevnsner T
    J Cell Sci; 2011 Dec; 124(Pt 23):3967-79. PubMed ID: 22159421
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Werner syndrome protein: linking the replication checkpoint response to genome stability.
    Pichierri P; Ammazzalorso F; Bignami M; Franchitto A
    Aging (Albany NY); 2011 Mar; 3(3):311-8. PubMed ID: 21389352
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.
    Cheng WH; Wu RT; Wu M; Rocourt CR; Carrillo JA; Song J; Bohr CT; Tzeng TJ
    Biochem Biophys Res Commun; 2012 Mar; 420(1):24-8. PubMed ID: 22390926
    [TBL] [Abstract][Full Text] [Related]  

  • 7. WRN participates in translesion synthesis pathway through interaction with NBS1.
    Kobayashi J; Okui M; Asaithamby A; Burma S; Chen BP; Tanimoto K; Matsuura S; Komatsu K; Chen DJ
    Mech Ageing Dev; 2010 Jun; 131(6):436-44. PubMed ID: 20600238
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
    Lee SJ; Gartner A; Hyun M; Ahn B; Koo HS
    PLoS Genet; 2010 Jan; 6(1):e1000801. PubMed ID: 20062519
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
    Otterlei M; Bruheim P; Ahn B; Bussen W; Karmakar P; Baynton K; Bohr VA
    J Cell Sci; 2006 Dec; 119(Pt 24):5137-46. PubMed ID: 17118963
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
    Aggarwal M; Banerjee T; Sommers JA; Iannascoli C; Pichierri P; Shoemaker RH; Brosh RM
    Cancer Res; 2013 Sep; 73(17):5497-507. PubMed ID: 23867477
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.
    Basile G; Leuzzi G; Pichierri P; Franchitto A
    Nucleic Acids Res; 2014 Nov; 42(20):12628-39. PubMed ID: 25352544
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rapid activation of ATM on DNA flanking double-strand breaks.
    You Z; Bailis JM; Johnson SA; Dilworth SM; Hunter T
    Nat Cell Biol; 2007 Nov; 9(11):1311-8. PubMed ID: 17952060
    [TBL] [Abstract][Full Text] [Related]  

  • 13. RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.
    Popuri V; Huang J; Ramamoorthy M; Tadokoro T; Croteau DL; Bohr VA
    Nucleic Acids Res; 2013 Jan; 41(2):881-99. PubMed ID: 23180761
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway.
    Su F; Bhattacharya S; Abdisalaam S; Mukherjee S; Yajima H; Yang Y; Mishra R; Srinivasan K; Ghose S; Chen DJ; Yannone SM; Asaithamby A
    Oncotarget; 2016 Jan; 7(1):46-65. PubMed ID: 26695548
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
    Trego KS; Chernikova SB; Davalos AR; Perry JJ; Finger LD; Ng C; Tsai MS; Yannone SM; Tainer JA; Campisi J; Cooper PK
    Cell Cycle; 2011 Jun; 10(12):1998-2007. PubMed ID: 21558802
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
    Kurose A; Tanaka T; Huang X; Traganos F; Dai W; Darzynkiewicz Z
    Cytometry A; 2006 Apr; 69(4):212-21. PubMed ID: 16528719
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
    Aggarwal M; Sommers JA; Shoemaker RH; Brosh RM
    Proc Natl Acad Sci U S A; 2011 Jan; 108(4):1525-30. PubMed ID: 21220316
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.
    Murfuni I; De Santis A; Federico M; Bignami M; Pichierri P; Franchitto A
    Carcinogenesis; 2012 Sep; 33(9):1655-63. PubMed ID: 22689923
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.
    Pichierri P; Nicolai S; Cignolo L; Bignami M; Franchitto A
    Oncogene; 2012 Jun; 31(23):2809-23. PubMed ID: 22002307
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Interplay between wrn and the checkpoint in s-phase.
    Pichierri P
    Ital J Biochem; 2007 Jun; 56(2):130-40. PubMed ID: 17722654
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.