BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

250 related articles for article (PubMed ID: 18599481)

  • 1. Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis.
    Kyriazis GA; Wei Z; Vandermey M; Jo DG; Xin O; Mattson MP; Chan SL
    J Biol Chem; 2008 Sep; 283(37):25492-25502. PubMed ID: 18599481
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model.
    Chigurupati S; Madan M; Okun E; Wei Z; Pattisapu JV; Mughal MR; Mattson MP; Chan SL
    J Alzheimers Dis; 2011; 24(2):349-61. PubMed ID: 21258150
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease.
    Chan SL; Pedersen WA; Zhu H; Mattson MP
    Neuromolecular Med; 2002; 1(1):55-67. PubMed ID: 12025816
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.
    Sun M; Asghar SZ; Zhang H
    Neurobiol Dis; 2016 Sep; 93():1-11. PubMed ID: 27072891
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 Cells.
    Pedersen WA; Chan SL; Zhu H; Abdur-Rahman LA; Verdi JM; Mattson MP
    J Neurochem; 2002 Aug; 82(4):976-86. PubMed ID: 12358803
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The PTB and PRR domains of numb regulate neurite outgrowth by influencing voltage-gated calcium channel expression and kinetics.
    Wang G; Zhang Z; Li J; Han J; Lu C
    Brain Res Bull; 2024 Feb; 207():110876. PubMed ID: 38215950
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation.
    Sullivan SE; Dillon GM; Sullivan JM; Ho A
    J Biol Chem; 2014 May; 289(22):15374-83. PubMed ID: 24742670
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
    Kyriazis GA; Belal C; Madan M; Taylor DG; Wang J; Wei Z; Pattisapu JV; Chan SL
    J Biol Chem; 2010 Feb; 285(9):6811-25. PubMed ID: 20038578
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization.
    Merthan L; Haller A; Thal DR; von Einem B; von Arnim CAF
    Biochem J; 2019 Jul; 476(14):2093-2109. PubMed ID: 31300465
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.
    Dho SE; French MB; Woods SA; McGlade CJ
    J Biol Chem; 1999 Nov; 274(46):33097-104. PubMed ID: 10551880
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner.
    Fassa A; Mehta P; Efthimiopoulos S
    J Neurosci Res; 2005 Oct; 82(2):214-24. PubMed ID: 16175584
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
    Chau DD; Yung KW; Chan WW; An Y; Hao Y; Chan HE; Ngo JC; Lau KF
    FASEB J; 2019 Nov; 33(11):12019-12035. PubMed ID: 31373844
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
    Borg JP; Ooi J; Levy E; Margolis B
    Mol Cell Biol; 1996 Nov; 16(11):6229-41. PubMed ID: 8887653
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.
    Yang GZ; Yang M; Lim Y; Lu JJ; Wang TH; Qi JG; Zhong JH; Zhou XF
    J Neurochem; 2012 Sep; 122(5):1010-22. PubMed ID: 22731248
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.
    Kinoshita A; Whelan CM; Smith CJ; Mikhailenko I; Rebeck GW; Strickland DK; Hyman BT
    J Neurosci; 2001 Nov; 21(21):8354-61. PubMed ID: 11606623
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.
    Borg JP; Yang Y; De Taddéo-Borg M; Margolis B; Turner RS
    J Biol Chem; 1998 Jun; 273(24):14761-6. PubMed ID: 9614075
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.
    Prasad H; Rao R
    J Biol Chem; 2015 Feb; 290(9):5311-27. PubMed ID: 25561733
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.
    Roncarati R; Sestan N; Scheinfeld MH; Berechid BE; Lopez PA; Meucci O; McGlade JC; Rakic P; D'Adamio L
    Proc Natl Acad Sci U S A; 2002 May; 99(10):7102-7. PubMed ID: 12011466
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.
    Runz H; Rietdorf J; Tomic I; de Bernard M; Beyreuther K; Pepperkok R; Hartmann T
    J Neurosci; 2002 Mar; 22(5):1679-89. PubMed ID: 11880497
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.
    Beyer AS; von Einem B; Schwanzar D; Keller IE; Hellrung A; Thal DR; Ingelsson M; Makarova A; Deng M; Chhabra ES; Pröpper C; Böckers TM; Hyman BT; von Arnim CA
    Neurobiol Aging; 2012 Apr; 33(4):732-43. PubMed ID: 20674096
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.