These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
115 related articles for article (PubMed ID: 18600534)
1. Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. Giovannetti E; Backus HH; Wouters D; Peters GJ Nucleosides Nucleotides Nucleic Acids; 2008 Jun; 27(6):740-5. PubMed ID: 18600534 [TBL] [Abstract][Full Text] [Related]
2. Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Giovannetti E; Backus HH; Wouters D; Ferreira CG; van Houten VM; Brakenhoff RH; Poupon MF; Azzarello A; Pinedo HM; Peters GJ Br J Cancer; 2007 Mar; 96(5):769-75. PubMed ID: 17339891 [TBL] [Abstract][Full Text] [Related]
3. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates. Longley DB; Boyer J; Allen WL; Latif T; Ferguson PR; Maxwell PJ; McDermott U; Lynch M; Harkin DP; Johnston PG Cancer Res; 2002 May; 62(9):2644-9. PubMed ID: 11980662 [TBL] [Abstract][Full Text] [Related]
4. Chronic exposure of colorectal cancer cells in culture to fluoropyrimidine analogs induces thymidylate synthase and suppresses p53. A molecular explanation for the mechanism of 5-FU resistance. Subbarayan PR; Sarkar M; Nelson G; Benitez E; Singhal S; Ardalan B Anticancer Res; 2010 Apr; 30(4):1149-56. PubMed ID: 20530421 [TBL] [Abstract][Full Text] [Related]
5. Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. Xi Y; Nakajima G; Schmitz JC; Chu E; Ju J BMC Genomics; 2006 Apr; 7():68. PubMed ID: 16584549 [TBL] [Abstract][Full Text] [Related]
6. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Lenz HJ; Hayashi K; Salonga D; Danenberg KD; Danenberg PV; Metzger R; Banerjee D; Bertino JR; Groshen S; Leichman LP; Leichman CG Clin Cancer Res; 1998 May; 4(5):1243-50. PubMed ID: 9607583 [TBL] [Abstract][Full Text] [Related]
7. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718 [TBL] [Abstract][Full Text] [Related]
8. CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells. Takagi K; Sowa Y; Cevik OM; Nakanishi R; Sakai T Int J Oncol; 2008 May; 32(5):1105-10. PubMed ID: 18425338 [TBL] [Abstract][Full Text] [Related]
9. Influence of p53 status on radiation and 5-flourouracil synergy in pancreatic cancer cells. Mohiuddin M; Chendil D; Dey S; Alcock RA; Regine W; Mohiuddin M; Ahmed MM Anticancer Res; 2002; 22(2A):825-30. PubMed ID: 12014658 [TBL] [Abstract][Full Text] [Related]
10. Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer. Nita ME; Tominaga O; Nagawa H; Tsuruo T; Muto T Hepatogastroenterology; 1998; 45(24):2117-22. PubMed ID: 9951876 [TBL] [Abstract][Full Text] [Related]
11. Arsenic trioxide suppresses thymidylate synthase in 5-FU-resistant colorectal cancer cell line HT29 In Vitro re-sensitizing cells to 5-FU. Subbarayan PR; Lee K; Ardalan B Anticancer Res; 2010 Apr; 30(4):1157-62. PubMed ID: 20530422 [TBL] [Abstract][Full Text] [Related]
12. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen. Grem JL; Danenberg KD; Behan K; Parr A; Young L; Danenberg PV; Nguyen D; Drake J; Monks A; Allegra CJ Clin Cancer Res; 2001 Apr; 7(4):999-1009. PubMed ID: 11309351 [TBL] [Abstract][Full Text] [Related]
13. Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma. Wong NA; Brett L; Stewart M; Leitch A; Longley DB; Dunlop MG; Johnston PG; Lessells AM; Jodrell DI Br J Cancer; 2001 Dec; 85(12):1937-43. PubMed ID: 11747337 [TBL] [Abstract][Full Text] [Related]
14. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Johnston PG; Lenz HJ; Leichman CG; Danenberg KD; Allegra CJ; Danenberg PV; Leichman L Cancer Res; 1995 Apr; 55(7):1407-12. PubMed ID: 7882343 [TBL] [Abstract][Full Text] [Related]
15. The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil. Matsuoka K; Tsukuda K; Suda M; Kobayashi K; Ota T; Okita A; Watanabe K; Suzuki E; Murakami M; Doihara H; Shimizu N Int J Oncol; 2004 Jan; 24(1):217-22. PubMed ID: 14654960 [TBL] [Abstract][Full Text] [Related]
16. Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks. Wang W; McLeod HL; Cassidy J; Collie-Duguid ES Cancer Chemother Pharmacol; 2007 May; 59(6):839-45. PubMed ID: 17119966 [TBL] [Abstract][Full Text] [Related]
17. Thymidylate synthase: a critical target for cancer chemotherapy. Rose MG; Farrell MP; Schmitz JC Clin Colorectal Cancer; 2002 Feb; 1(4):220-9. PubMed ID: 12450420 [TBL] [Abstract][Full Text] [Related]
18. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions. Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030 [TBL] [Abstract][Full Text] [Related]
19. [Results of prophylactic hepatic arterial chemotherapy for liver metastases of Dukes C colorectal cancer--correlation with tumoral expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53, or orotate phosphoribosyl transferase]. Ishida H; Yamada H; Shirakawa K; Nakada H; Ohsawa T; Takeuchi I; Okada N; Yokoyama M; Inokuma S; Suzuki T; Odaka A; Hoshino T; Murata N; Hashimoto D; Itoyama S; Mori T; Matsumoto Y; Miura T Gan To Kagaku Ryoho; 2003 Oct; 30(11):1621-6. PubMed ID: 14619479 [TBL] [Abstract][Full Text] [Related]
20. Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer. Okumura K; Mekata E; Shiomi H; Naitoh H; Abe H; Endo Y; Kurumi Y; Tani T Cancer Chemother Pharmacol; 2008 Apr; 61(4):587-94. PubMed ID: 17520254 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]