These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

98 related articles for article (PubMed ID: 18603434)

  • 1. The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1.
    Prakesch M; Denisov AY; Naim M; Gehring K; Arya P
    Bioorg Med Chem; 2008 Aug; 16(15):7443-9. PubMed ID: 18603434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological activities of new di- and trimeric quinoline derivatives.
    Broch S; Hénon H; Debaud AL; Fogeron ML; Bonnefoy-Bérard N; Anizon F; Moreau P
    Bioorg Med Chem; 2010 Oct; 18(19):7132-43. PubMed ID: 20800501
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.
    Yin H; Lee GI; Sedey KA; Kutzki O; Park HS; Orner BP; Ernst JT; Wang HG; Sebti SM; Hamilton AD
    J Am Chem Soc; 2005 Jul; 127(29):10191-6. PubMed ID: 16028929
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction.
    Yin H; Lee GI; Sedey KA; Rodriguez JM; Wang HG; Sebti SM; Hamilton AD
    J Am Chem Soc; 2005 Apr; 127(15):5463-8. PubMed ID: 15826183
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
    Petros AM; Dinges J; Augeri DJ; Baumeister SA; Betebenner DA; Bures MG; Elmore SW; Hajduk PJ; Joseph MK; Landis SK; Nettesheim DG; Rosenberg SH; Shen W; Thomas S; Wang X; Zanze I; Zhang H; Fesik SW
    J Med Chem; 2006 Jan; 49(2):656-63. PubMed ID: 16420051
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and molecular modeling study of new trimeric quinoline derivatives.
    Saugues E; Nauton L; Théry V; Anizon F; Moreau P
    Bioorg Chem; 2011 Aug; 39(4):143-50. PubMed ID: 21807395
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface.
    Rodriguez JM; Ross NT; Katt WP; Dhar D; Lee GI; Hamilton AD
    ChemMedChem; 2009 Apr; 4(4):649-56. PubMed ID: 19330783
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular dynamics study of small molecule inhibitors of the Bcl-2 family.
    Acoca S; Cui Q; Shore GC; Purisima EO
    Proteins; 2011 Sep; 79(9):2624-36. PubMed ID: 21721047
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.
    Song T; Li X; Chang X; Liang X; Zhao Y; Wu G; Xie S; Su P; Wu Z; Feng Y; Zhang Z
    Bioorg Med Chem; 2013 Jan; 21(1):11-20. PubMed ID: 23206987
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
    Petros AM; Huth JR; Oost T; Park CM; Ding H; Wang X; Zhang H; Nimmer P; Mendoza R; Sun C; Mack J; Walter K; Dorwin S; Gramling E; Ladror U; Rosenberg SH; Elmore SW; Fesik SW; Hajduk PJ
    Bioorg Med Chem Lett; 2010 Nov; 20(22):6587-91. PubMed ID: 20870405
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.
    Bernardo PH; Sivaraman T; Wan KF; Xu J; Krishnamoorthy J; Song CM; Tian L; Chin JS; Lim DS; Mok HY; Yu VC; Tong JC; Chai CL
    J Med Chem; 2010 Mar; 53(5):2314-8. PubMed ID: 20158203
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems.
    Etxebarria A; Landeta O; Antonsson B; Basañez G
    Biochem Pharmacol; 2008 Dec; 76(11):1563-76. PubMed ID: 18762177
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
    Feng Y; Ding X; Chen T; Chen L; Liu F; Jia X; Luo X; Shen X; Chen K; Jiang H; Wang H; Liu H; Liu D
    J Med Chem; 2010 May; 53(9):3465-79. PubMed ID: 20405848
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ligand specificity in fragment-based drug design.
    Barelier S; Pons J; Gehring K; Lancelin JM; Krimm I
    J Med Chem; 2010 Jul; 53(14):5256-66. PubMed ID: 20575554
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein.
    Yin H; Hamilton AD
    Bioorg Med Chem Lett; 2004 Mar; 14(6):1375-9. PubMed ID: 15006365
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
    Friberg A; Vigil D; Zhao B; Daniels RN; Burke JP; Garcia-Barrantes PM; Camper D; Chauder BA; Lee T; Olejniczak ET; Fesik SW
    J Med Chem; 2013 Jan; 56(1):15-30. PubMed ID: 23244564
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fragment-based deconstruction of Bcl-xL inhibitors.
    Barelier S; Pons J; Marcillat O; Lancelin JM; Krimm I
    J Med Chem; 2010 Mar; 53(6):2577-88. PubMed ID: 20192224
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and development of thiazolo[3,2-a]pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins.
    Zhou B; Li X; Li Y; Xu Y; Zhang Z; Zhou M; Zhang X; Liu Z; Zhou J; Cao C; Yu B; Wang R
    ChemMedChem; 2011 May; 6(5):904-21. PubMed ID: 21520420
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.
    Marcaurelle LA; Johannes C; Yohannes D; Tillotson BP; Mann D
    Bioorg Med Chem Lett; 2009 May; 19(9):2500-3. PubMed ID: 19329314
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach.
    Di Micco S; Vitale R; Pellecchia M; Rega MF; Riva R; Basso A; Bifulco G
    J Med Chem; 2009 Dec; 52(23):7856-67. PubMed ID: 19852471
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.