These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 18617167)

  • 1. Leishmania donovani pteridine reductase 1: biochemical properties and structure-modeling studies.
    Kumar P; Kumar A; Verma SS; Dwivedi N; Singh N; Siddiqi MI; Tripathi RP; Dube A; Singh N
    Exp Parasitol; 2008 Sep; 120(1):73-9. PubMed ID: 18617167
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani.
    Kaur J; Sundar S; Singh N
    J Antimicrob Chemother; 2010 Aug; 65(8):1742-8. PubMed ID: 20519355
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani.
    Kumar P; Kothari H; Singh N
    Protein Expr Purif; 2004 Dec; 38(2):228-36. PubMed ID: 15555938
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Leishmania donovani: a glycosyl dihydropyridine analogue induces apoptosis like cell death via targeting pteridine reductase 1 in promastigotes.
    Kaur J; Singh BK; Tripathi RP; Singh P; Singh N
    Exp Parasitol; 2009 Nov; 123(3):258-64. PubMed ID: 19647734
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1.
    Singh N; Kaur J; Kumar P; Gupta S; Singh N; Ghosal A; Dutta A; Kumar A; Tripathi R; Siddiqi MI; Mandal C; Dube A
    Parasitol Res; 2009 Oct; 105(5):1317-25. PubMed ID: 19621245
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.
    Schüttelkopf AW; Hardy LW; Beverley SM; Hunter WN
    J Mol Biol; 2005 Sep; 352(1):105-16. PubMed ID: 16055151
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
    Schormann N; Pal B; Senkovich O; Carson M; Howard A; Smith C; Delucas L; Chattopadhyay D
    J Struct Biol; 2005 Oct; 152(1):64-75. PubMed ID: 16168672
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In silico screening, structure-activity relationship, and biologic evaluation of selective pteridine reductase inhibitors targeting visceral leishmaniasis.
    Kaur J; Kumar P; Tyagi S; Pathak R; Batra S; Singh P; Singh N
    Antimicrob Agents Chemother; 2011 Feb; 55(2):659-66. PubMed ID: 21115787
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani.
    Kumar P; Sundar S; Singh N
    Exp Parasitol; 2007 Jun; 116(2):182-9. PubMed ID: 17275814
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of Piper longum.
    Sahi S; Tewatia P; Ghosal S
    J Mol Model; 2012 Dec; 18(12):5065-73. PubMed ID: 22752544
    [TBL] [Abstract][Full Text] [Related]  

  • 11. New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.
    Nare B; Luba J; Hardy LW; Beverley S
    Parasitology; 1997; 114 Suppl():S101-10. PubMed ID: 9309772
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways.
    Hardy LW; Matthews W; Nare B; Beverley SM
    Exp Parasitol; 1997 Nov; 87(3):157-69. PubMed ID: 9371081
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exploring the inhibitory activity of Withaferin-A against Pteridine reductase-1 of L. donovani.
    Chandrasekaran S; Veronica J; Gundampati RK; Sundar S; Maurya R
    J Enzyme Inhib Med Chem; 2016 Dec; 31(6):1029-37. PubMed ID: 26406482
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
    Nare B; Hardy LW; Beverley SM
    J Biol Chem; 1997 May; 272(21):13883-91. PubMed ID: 9153248
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
    Luba J; Nare B; Liang PH; Anderson KS; Beverley SM; Hardy LW
    Biochemistry; 1998 Mar; 37(12):4093-104. PubMed ID: 9521731
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
    Chan C; Yin H; Garforth J; McKie JH; Jaouhari R; Speers P; Douglas KT; Rock PJ; Yardley V; Croft SL; Fairlamb AH
    J Med Chem; 1998 Jan; 41(2):148-56. PubMed ID: 9457238
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
    Khabnadideh S; Pez D; Musso A; Brun R; Pérez LM; González-Pacanowska D; Gilbert IH
    Bioorg Med Chem; 2005 Apr; 13(7):2637-49. PubMed ID: 15755663
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
    Gourley DG; Schüttelkopf AW; Leonard GA; Luba J; Hardy LW; Beverley SM; Hunter WN
    Nat Struct Biol; 2001 Jun; 8(6):521-5. PubMed ID: 11373620
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and molecular docking studies of 1-phenyl-4-glycosyl-dihydropyridines as potent antileishmanial agents.
    Pandey VP; Bisht SS; Mishra M; Kumar A; Siddiqi MI; Verma A; Mittal M; Sane SA; Gupta S; Tripathi RP
    Eur J Med Chem; 2010 Jun; 45(6):2381-8. PubMed ID: 20199824
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.
    Wang J; Leblanc E; Chang CF; Papadopoulou B; Bray T; Whiteley JM; Lin SX; Ouellette M
    Arch Biochem Biophys; 1997 Jun; 342(2):197-202. PubMed ID: 9186479
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.