86 related articles for article (PubMed ID: 18620380)
1. Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid.
Dhagat U; Endo S; Sumii R; Hara A; El-Kabbani O
J Med Chem; 2008 Aug; 51(15):4844-8. PubMed ID: 18620380
[TBL] [Abstract][Full Text] [Related]
2. Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.
Carbone V; Chung R; Endo S; Hara A; El-Kabbani O
Arch Biochem Biophys; 2008 Nov; 479(1):82-7. PubMed ID: 18782556
[TBL] [Abstract][Full Text] [Related]
3. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).
El-Kabbani O; Scammells PJ; Gosling J; Dhagat U; Endo S; Matsunaga T; Soda M; Hara A
J Med Chem; 2009 May; 52(10):3259-64. PubMed ID: 19397269
[TBL] [Abstract][Full Text] [Related]
4. Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis.
El-Kabbani O; Dhagat U; Soda M; Endo S; Matsunaga T; Hara A
Bioorg Med Chem Lett; 2011 Apr; 21(8):2564-7. PubMed ID: 21414777
[TBL] [Abstract][Full Text] [Related]
5. Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1).
El-Kabbani O; Dhagat U; Hara A
J Steroid Biochem Mol Biol; 2011 May; 125(1-2):105-11. PubMed ID: 21050889
[TBL] [Abstract][Full Text] [Related]
6. Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
Couture JF; Legrand P; Cantin L; Labrie F; Luu-The V; Breton R
J Mol Biol; 2004 May; 339(1):89-102. PubMed ID: 15123423
[TBL] [Abstract][Full Text] [Related]
7. Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
Couture JF; Legrand P; Cantin L; Luu-The V; Labrie F; Breton R
J Mol Biol; 2003 Aug; 331(3):593-604. PubMed ID: 12899831
[TBL] [Abstract][Full Text] [Related]
8. Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.
El-Kabbani O; Scammells PJ; Day T; Dhagat U; Endo S; Matsunaga T; Soda M; Hara A
Eur J Med Chem; 2010 Nov; 45(11):5309-17. PubMed ID: 20850205
[TBL] [Abstract][Full Text] [Related]
9. Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.
Dhagat U; Endo S; Soda M; Hara A; El-Kabbani O
Bioorg Med Chem Lett; 2010 Sep; 20(17):5274-6. PubMed ID: 20656485
[TBL] [Abstract][Full Text] [Related]
10. Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity.
Zhang B; Zhu DW; Hu XJ; Zhou M; Shang P; Lin SX
J Steroid Biochem Mol Biol; 2014 May; 141():135-43. PubMed ID: 24434280
[TBL] [Abstract][Full Text] [Related]
11. Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.
Faucher F; Cantin L; Pereira de Jésus-Tran K; Lemieux M; Luu-The V; Labrie F; Breton R
J Mol Biol; 2007 Jun; 369(2):525-40. PubMed ID: 17442338
[TBL] [Abstract][Full Text] [Related]
12. Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
Carbone V; Sumii R; Ishikura S; Asada Y; Hara A; El-Kabbani O
Acta Crystallogr D Biol Crystallogr; 2008 May; 64(Pt 5):532-42. PubMed ID: 18453689
[TBL] [Abstract][Full Text] [Related]
13. Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency.
Svensson S; Höög JO; Schneider G; Sandalova T
J Mol Biol; 2000 Sep; 302(2):441-53. PubMed ID: 10970744
[TBL] [Abstract][Full Text] [Related]
14. Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.
Qiu W; Zhou M; Mazumdar M; Azzi A; Ghanmi D; Luu-The V; Labrie F; Lin SX
J Biol Chem; 2007 Mar; 282(11):8368-79. PubMed ID: 17166832
[TBL] [Abstract][Full Text] [Related]
15. Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.
Carbone V; Zhao HT; Chung R; Endo S; Hara A; El-Kabbani O
Bioorg Med Chem; 2009 Feb; 17(3):1244-50. PubMed ID: 19121944
[TBL] [Abstract][Full Text] [Related]
16. Unique coenzyme binding mode of hyperthermophilic archaeal sn-glycerol-1-phosphate dehydrogenase from Pyrobaculum calidifontis.
Hayashi J; Yamamoto K; Yoneda K; Ohshima T; Sakuraba H
Proteins; 2016 Dec; 84(12):1786-1796. PubMed ID: 27616573
[TBL] [Abstract][Full Text] [Related]
17. Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex.
Bond CS; White MF; Hunter WN
J Mol Biol; 2002 Mar; 316(5):1071-81. PubMed ID: 11884145
[TBL] [Abstract][Full Text] [Related]
18. Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase.
Endo S; Arai Y; Hara A; Kitade Y; Bunai Y; El-Kabbani O; Matsunaga T
Biol Pharm Bull; 2013; 36(9):1514-8. PubMed ID: 23995665
[TBL] [Abstract][Full Text] [Related]
19. Structure of Toxoplasma gondii LDH1: active-site differences from human lactate dehydrogenases and the structural basis for efficient APAD+ use.
Kavanagh KL; Elling RA; Wilson DK
Biochemistry; 2004 Feb; 43(4):879-89. PubMed ID: 14744130
[TBL] [Abstract][Full Text] [Related]
20. Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.
Faucher F; Pereira de Jésus-Tran K; Cantin L; Luu-The V; Labrie F; Breton R
J Mol Biol; 2006 Dec; 364(4):747-63. PubMed ID: 17034817
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
