These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

412 related articles for article (PubMed ID: 18621733)

  • 1. Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domain.
    Manna D; Bhardwaj N; Vora MS; Stahelin RV; Lu H; Cho W
    J Biol Chem; 2008 Sep; 283(38):26047-58. PubMed ID: 18621733
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The C2 domains of classical PKCs are specific PtdIns(4,5)P2-sensing domains with different affinities for membrane binding.
    Guerrero-Valero M; Marín-Vicente C; Gómez-Fernández JC; Corbalán-García S
    J Mol Biol; 2007 Aug; 371(3):608-21. PubMed ID: 17586528
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.
    Sánchez-Bautista S; Marín-Vicente C; Gómez-Fernández JC; Corbalán-García S
    J Mol Biol; 2006 Oct; 362(5):901-14. PubMed ID: 16949603
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.
    Corbin JA; Evans JH; Landgraf KE; Falke JJ
    Biochemistry; 2007 Apr; 46(14):4322-36. PubMed ID: 17367165
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2.
    Guerrero-Valero M; Ferrer-Orta C; Querol-Audí J; Marin-Vicente C; Fita I; Gómez-Fernández JC; Verdaguer N; Corbalán-García S
    Proc Natl Acad Sci U S A; 2009 Apr; 106(16):6603-7. PubMed ID: 19346474
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.
    Lai CL; Landgraf KE; Voth GA; Falke JJ
    J Mol Biol; 2010 Sep; 402(2):301-10. PubMed ID: 20659476
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains.
    Manna D; Albanese A; Park WS; Cho W
    J Biol Chem; 2007 Nov; 282(44):32093-105. PubMed ID: 17823121
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells.
    Marín-Vicente C; Nicolás FE; Gómez-Fernández JC; Corbalán-García S
    J Mol Biol; 2008 Apr; 377(4):1038-52. PubMed ID: 18304574
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The origin of C1A-C2 interdomain interactions in protein kinase Calpha.
    Stahelin RV; Wang J; Blatner NR; Rafter JD; Murray D; Cho W
    J Biol Chem; 2005 Oct; 280(43):36452-63. PubMed ID: 16079140
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha.
    Rodríguez-Alfaro JA; Gomez-Fernandez JC; Corbalan-Garcia S
    J Mol Biol; 2004 Jan; 335(4):1117-29. PubMed ID: 14698304
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.
    Landgraf KE; Malmberg NJ; Falke JJ
    Biochemistry; 2008 Aug; 47(32):8301-16. PubMed ID: 18610985
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.
    Evans JH; Murray D; Leslie CC; Falke JJ
    Mol Biol Cell; 2006 Jan; 17(1):56-66. PubMed ID: 16236797
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
    Ivetac I; Munday AD; Kisseleva MV; Zhang XM; Luff S; Tiganis T; Whisstock JC; Rowe T; Majerus PW; Mitchell CA
    Mol Biol Cell; 2005 May; 16(5):2218-33. PubMed ID: 15716355
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
    Rameh LE; Arvidsson Ak; Carraway KL; Couvillon AD; Rathbun G; Crompton A; VanRenterghem B; Czech MP; Ravichandran KS; Burakoff SJ; Wang DS; Chen CS; Cantley LC
    J Biol Chem; 1997 Aug; 272(35):22059-66. PubMed ID: 9268346
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α.
    Ziemba BP; Li J; Landgraf KE; Knight JD; Voth GA; Falke JJ
    Biochemistry; 2014 Mar; 53(10):1697-713. PubMed ID: 24559055
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P
    Ghai R; Du X; Wang H; Dong J; Ferguson C; Brown AJ; Parton RG; Wu JW; Yang H
    Nat Commun; 2017 Oct; 8(1):757. PubMed ID: 28970484
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells.
    Marín-Vicente C; Gómez-Fernández JC; Corbalán-García S
    Mol Biol Cell; 2005 Jun; 16(6):2848-61. PubMed ID: 15814842
    [TBL] [