BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

351 related articles for article (PubMed ID: 18628403)

  • 21. Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.
    Avlani VA; Langmead CJ; Guida E; Wood MD; Tehan BG; Herdon HJ; Watson JM; Sexton PM; Christopoulos A
    Mol Pharmacol; 2010 Jul; 78(1):94-104. PubMed ID: 20413650
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
    Chen X; Choo H; Huang XP; Yang X; Stone O; Roth BL; Jin J
    ACS Chem Neurosci; 2015 Mar; 6(3):476-84. PubMed ID: 25587888
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.
    Berizzi AE; Gentry PR; Rueda P; Den Hoedt S; Sexton PM; Langmead CJ; Christopoulos A
    Mol Pharmacol; 2016 Oct; 90(4):427-36. PubMed ID: 27461343
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
    Gomez JL; Bonaventura J; Lesniak W; Mathews WB; Sysa-Shah P; Rodriguez LA; Ellis RJ; Richie CT; Harvey BK; Dannals RF; Pomper MG; Bonci A; Michaelides M
    Science; 2017 Aug; 357(6350):503-507. PubMed ID: 28774929
    [TBL] [Abstract][Full Text] [Related]  

  • 25. LY2033298, a positive allosteric modulator at muscarinic M₄ receptors, enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms.
    Gannon RL; Millan MJ
    Psychopharmacology (Berl); 2012 Nov; 224(2):231-40. PubMed ID: 22610522
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.
    Lazareno S; Birdsall B; Fukazawa T; Gharagozloo P; Hashimoto T; Kuwano H; Popham A; Sugimoto M; Birdsall NJ
    Life Sci; 1999; 64(6-7):519-26. PubMed ID: 10069518
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.
    Keov P; Valant C; Devine SM; Lane JR; Scammells PJ; Sexton PM; Christopoulos A
    Mol Pharmacol; 2013 Sep; 84(3):425-37. PubMed ID: 23798605
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
    Thal DM; Sun B; Feng D; Nawaratne V; Leach K; Felder CC; Bures MG; Evans DA; Weis WI; Bachhawat P; Kobilka TS; Sexton PM; Kobilka BK; Christopoulos A
    Nature; 2016 Mar; 531(7594):335-40. PubMed ID: 26958838
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
    Jakubík J; Randáková A; El-Fakahany EE; Dolezal V
    BMC Pharmacol; 2009 Dec; 9():15. PubMed ID: 20038295
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Biased Profile of Xanomeline at the Recombinant Human M
    McDonald JK; van der Westhuizen ET; Pham V; Thompson G; Felder CC; Paul SM; Thal DM; Christopoulos A; Valant C
    ACS Chem Neurosci; 2022 Apr; 13(8):1206-1218. PubMed ID: 35380782
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
    Jakubík J; Bacáková L; El-Fakahany EE; Tucek S
    Mol Pharmacol; 1997 Jul; 52(1):172-9. PubMed ID: 9224827
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.
    Birdsall NJ; Farries T; Gharagozloo P; Kobayashi S; Lazareno S; Sugimoto M
    Mol Pharmacol; 1999 Apr; 55(4):778-86. PubMed ID: 10101037
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors.
    Michal P; Lysíková M; El-Fakahany EE; Tucek S
    Eur J Pharmacol; 1999 Jul; 376(1-2):119-25. PubMed ID: 10440097
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structure-based discovery of selective positive allosteric modulators of antagonists for the M
    Korczynska M; Clark MJ; Valant C; Xu J; Moo EV; Albold S; Weiss DR; Torosyan H; Huang W; Kruse AC; Lyda BR; May LT; Baltos JA; Sexton PM; Kobilka BK; Christopoulos A; Shoichet BK; Sunahara RK
    Proc Natl Acad Sci U S A; 2018 Mar; 115(10):E2419-E2428. PubMed ID: 29453275
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias.
    Gregory KJ; Hall NE; Tobin AB; Sexton PM; Christopoulos A
    J Biol Chem; 2010 Mar; 285(10):7459-74. PubMed ID: 20051519
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
    Abdul-Ridha A; Lane JR; Mistry SN; López L; Sexton PM; Scammells PJ; Christopoulos A; Canals M
    J Biol Chem; 2014 Nov; 289(48):33701-11. PubMed ID: 25326383
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The muscarinic acetylcholine receptor agonist BuTAC mediates antipsychotic-like effects via the M4 subtype.
    Watt ML; Rorick-Kehn L; Shaw DB; Knitowski KM; Quets AT; Chesterfield AK; McKinzie DL; Felder CC
    Neuropsychopharmacology; 2013 Dec; 38(13):2717-26. PubMed ID: 23907402
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.
    Abdul-Ridha A; López L; Keov P; Thal DM; Mistry SN; Sexton PM; Lane JR; Canals M; Christopoulos A
    J Biol Chem; 2014 Feb; 289(9):6067-79. PubMed ID: 24443568
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery and Development of Muscarinic Acetylcholine M
    Takai K; Enomoto T
    Chem Pharm Bull (Tokyo); 2018; 66(1):37-44. PubMed ID: 29311510
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
    Smith DL; Davoren JE; Edgerton JR; Lazzaro JT; Lee CW; Neal S; Zhang L; Grimwood S
    Mol Pharmacol; 2016 Sep; 90(3):177-87. PubMed ID: 27382013
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 18.