BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 18642817)

  • 1. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
    Bowers A; West N; Taunton J; Schreiber SL; Bradner JE; Williams RM
    J Am Chem Soc; 2008 Aug; 130(33):11219-22. PubMed ID: 18642817
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.
    Wang B; Huang PH; Chen CS; Forsyth CJ
    J Org Chem; 2011 Feb; 76(4):1140-50. PubMed ID: 21244075
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.
    Ying Y; Taori K; Kim H; Hong J; Luesch H
    J Am Chem Soc; 2008 Jul; 130(26):8455-9. PubMed ID: 18507379
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and activity of largazole analogues with linker and macrocycle modification.
    Ying Y; Liu Y; Byeon SR; Kim H; Luesch H; Hong J
    Org Lett; 2008 Sep; 10(18):4021-4. PubMed ID: 18707106
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase.
    Ghosh AK; Kulkarni S
    Org Lett; 2008 Sep; 10(17):3907-9. PubMed ID: 18662003
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
    Bowers AA; Greshock TJ; West N; Estiu G; Schreiber SL; Wiest O; Williams RM; Bradner JE
    J Am Chem Soc; 2009 Mar; 131(8):2900-5. PubMed ID: 19193120
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells.
    Zeng X; Yin B; Hu Z; Liao C; Liu J; Li S; Li Z; Nicklaus MC; Zhou G; Jiang S
    Org Lett; 2010 Mar; 12(6):1368-71. PubMed ID: 20184338
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
    Bhansali P; Hanigan CL; Casero RA; Tillekeratne LM
    J Med Chem; 2011 Nov; 54(21):7453-63. PubMed ID: 21936551
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.
    Liu Y; Salvador LA; Byeon S; Ying Y; Kwan JC; Law BK; Hong J; Luesch H
    J Pharmacol Exp Ther; 2010 Nov; 335(2):351-61. PubMed ID: 20739454
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of class I HDAC isoform selectivity of largazole analogues.
    Kim B; Park H; Salvador LA; Serrano PE; Kwan JC; Zeller SL; Chen QY; Ryu S; Liu Y; Byeon S; Luesch H; Hong J
    Bioorg Med Chem Lett; 2014 Aug; 24(16):3728-31. PubMed ID: 25070421
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A.
    Zhang B; Shan G; Zheng Y; Yu X; Ruan ZW; Li Y; Lei X
    Mar Drugs; 2019 Jun; 17(6):. PubMed ID: 31163697
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.
    Benelkebir H; Marie S; Hayden AL; Lyle J; Loadman PM; Crabb SJ; Packham G; Ganesan A
    Bioorg Med Chem; 2011 Jun; 19(12):3650-8. PubMed ID: 21420302
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.
    Poli G; Di Fabio R; Ferrante L; Summa V; Botta M
    ChemMedChem; 2017 Dec; 12(23):1917-1926. PubMed ID: 29117473
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.
    Li S; Yao H; Xu J; Jiang S
    Molecules; 2011 Jun; 16(6):4681-94. PubMed ID: 21654576
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of largazole zinc-binding group analogs.
    Kim B; Ratnayake R; Lee H; Shi G; Zeller SL; Li C; Luesch H; Hong J
    Bioorg Med Chem; 2017 Jun; 25(12):3077-3086. PubMed ID: 28416100
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.
    Bowers AA; West N; Newkirk TL; Troutman-Youngman AE; Schreiber SL; Wiest O; Bradner JE; Williams RM
    Org Lett; 2009 Mar; 11(6):1301-4. PubMed ID: 19239241
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.
    Almaliti J; Al-Hamashi AA; Negmeldin AT; Hanigan CL; Perera L; Pflum MK; Casero RA; Tillekeratne LM
    J Med Chem; 2016 Dec; 59(23):10642-10660. PubMed ID: 27809521
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
    Clausen DJ; Smith WB; Haines BE; Wiest O; Bradner JE; Williams RM
    Bioorg Med Chem; 2015 Aug; 23(15):5061-5074. PubMed ID: 26054247
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships.
    Nasveschuk CG; Ungermannova D; Liu X; Phillips AJ
    Org Lett; 2008 Aug; 10(16):3595-8. PubMed ID: 18616341
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups.
    Bhansali P; Hanigan CL; Perera L; Casero RA; Tillekeratne LM
    Eur J Med Chem; 2014 Oct; 86():528-41. PubMed ID: 25203782
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.