These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 18644861)

  • 21. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.
    Chaturvedi P; Eng WK; Zhu Y; Mattern MR; Mishra R; Hurle MR; Zhang X; Annan RS; Lu Q; Faucette LF; Scott GF; Li X; Carr SA; Johnson RK; Winkler JD; Zhou BB
    Oncogene; 1999 Jul; 18(28):4047-54. PubMed ID: 10435585
    [TBL] [Abstract][Full Text] [Related]  

  • 22. ATM-dependent CHK2 activation induced by anticancer agent, irofulven.
    Wang J; Wiltshire T; Wang Y; Mikell C; Burks J; Cunningham C; Van Laar ES; Waters SJ; Reed E; Wang W
    J Biol Chem; 2004 Sep; 279(38):39584-92. PubMed ID: 15269203
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
    Kurz EU; Douglas P; Lees-Miller SP
    J Biol Chem; 2004 Dec; 279(51):53272-81. PubMed ID: 15489221
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
    Huang M; Miao ZH; Zhu H; Cai YJ; Lu W; Ding J
    Mol Cancer Ther; 2008 Jun; 7(6):1440-9. PubMed ID: 18566216
    [TBL] [Abstract][Full Text] [Related]  

  • 25. ATM regulates ATR chromatin loading in response to DNA double-strand breaks.
    Cuadrado M; Martinez-Pastor B; Murga M; Toledo LI; Gutierrez-Martinez P; Lopez E; Fernandez-Capetillo O
    J Exp Med; 2006 Feb; 203(2):297-303. PubMed ID: 16461339
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
    Lee JH; Xu B; Lee CH; Ahn JY; Song MS; Lee H; Canman CE; Lee JS; Kastan MB; Lim DS
    Mol Cancer Res; 2003 Jul; 1(9):674-81. PubMed ID: 12861053
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
    Bahassi el M; Myer DL; McKenney RJ; Hennigan RF; Stambrook PJ
    Mutat Res; 2006 Apr; 596(1-2):166-76. PubMed ID: 16481012
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
    Gatei M; Sloper K; Sorensen C; Syljuäsen R; Falck J; Hobson K; Savage K; Lukas J; Zhou BB; Bartek J; Khanna KK
    J Biol Chem; 2003 Apr; 278(17):14806-11. PubMed ID: 12588868
    [TBL] [Abstract][Full Text] [Related]  

  • 29. DNA damage regulates Chk2 association with chromatin.
    Li J; Stern DF
    J Biol Chem; 2005 Nov; 280(45):37948-56. PubMed ID: 16150728
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
    Helt CE; Cliby WA; Keng PC; Bambara RA; O'Reilly MA
    J Biol Chem; 2005 Jan; 280(2):1186-92. PubMed ID: 15533933
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.
    Cui Y; Palii SS; Innes CL; Paules RS
    Cell Cycle; 2014; 13(22):3541-50. PubMed ID: 25483091
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.
    Gupta SK; Guo X; Durkin SS; Fryrear KF; Ward MD; Semmes OJ
    J Biol Chem; 2007 Oct; 282(40):29431-40. PubMed ID: 17698850
    [TBL] [Abstract][Full Text] [Related]  

  • 33. A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.
    Carlessi L; Buscemi G; Fontanella E; Delia D
    Biochim Biophys Acta; 2010 Oct; 1803(10):1213-23. PubMed ID: 20599567
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
    Zhang X; Succi J; Feng Z; Prithivirajsingh S; Story MD; Legerski RJ
    Mol Cell Biol; 2004 Oct; 24(20):9207-20. PubMed ID: 15456891
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis.
    Xu J; Xin S; Du W
    FEBS Lett; 2001 Nov; 508(3):394-8. PubMed ID: 11728459
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage.
    Brodsky MH; Weinert BT; Tsang G; Rong YS; McGinnis NM; Golic KG; Rio DC; Rubin GM
    Mol Cell Biol; 2004 Feb; 24(3):1219-31. PubMed ID: 14729967
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
    Jobson AG; Lountos GT; Lorenzi PL; Llamas J; Connelly J; Cerna D; Tropea JE; Onda A; Zoppoli G; Kondapaka S; Zhang G; Caplen NJ; Cardellina JH; Yoo SS; Monks A; Self C; Waugh DS; Shoemaker RH; Pommier Y
    J Pharmacol Exp Ther; 2009 Dec; 331(3):816-26. PubMed ID: 19741151
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
    Bahassi EM; Ovesen JL; Riesenberg AL; Bernstein WZ; Hasty PE; Stambrook PJ
    Oncogene; 2008 Jun; 27(28):3977-85. PubMed ID: 18317453
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Involvement of novel autophosphorylation sites in ATM activation.
    Kozlov SV; Graham ME; Peng C; Chen P; Robinson PJ; Lavin MF
    EMBO J; 2006 Aug; 25(15):3504-14. PubMed ID: 16858402
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.
    Goldstine JV; Nahas S; Gamo K; Gartler SM; Hansen RS; Roelfsema JH; Gatti RA; Marahrens Y
    DNA Repair (Amst); 2006 Apr; 5(4):432-43. PubMed ID: 16426903
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.