BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

290 related articles for article (PubMed ID: 18647858)

  • 1. Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by udp-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites.
    Uchaipichat V; Galetin A; Houston JB; Mackenzie PI; Williams JA; Miners JO
    Mol Pharmacol; 2008 Oct; 74(4):1152-62. PubMed ID: 18647858
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation.
    Lewis BC; Mackenzie PI; Elliot DJ; Burchell B; Bhasker CR; Miners JO
    Biochem Pharmacol; 2007 May; 73(9):1463-73. PubMed ID: 17223084
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.
    Uchaipichat V; Mackenzie PI; Guo XH; Gardner-Stephen D; Galetin A; Houston JB; Miners JO
    Drug Metab Dispos; 2004 Apr; 32(4):413-23. PubMed ID: 15039294
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic and inhibitor studies of 4-methylumbelliferone and 1-naphthol glucuronidation in human liver microsomes.
    Miners JO; Lillywhite KJ; Matthews AP; Jones ME; Birkett DJ
    Biochem Pharmacol; 1988 Feb; 37(4):665-71. PubMed ID: 3124857
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolation.
    Rowland A; Gaganis P; Elliot DJ; Mackenzie PI; Knights KM; Miners JO
    J Pharmacol Exp Ther; 2007 Apr; 321(1):137-47. PubMed ID: 17237258
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.
    Udomuksorn W; Elliot DJ; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
    Pharmacogenet Genomics; 2007 Dec; 17(12):1017-29. PubMed ID: 18004206
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.
    Kerdpin O; Mackenzie PI; Bowalgaha K; Finel M; Miners JO
    Drug Metab Dispos; 2009 Sep; 37(9):1948-55. PubMed ID: 19487247
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7.
    Gaganis P; Miners JO; Knights KM
    Biochem Pharmacol; 2007 May; 73(10):1683-91. PubMed ID: 17343829
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities.
    Rowland A; Knights KM; Mackenzie PI; Miners JO
    Drug Metab Dispos; 2008 Jun; 36(6):1056-62. PubMed ID: 18362158
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).
    Barbier O; Turgeon D; Girard C; Green MD; Tephly TR; Hum DW; Bélanger A
    Drug Metab Dispos; 2000 May; 28(5):497-502. PubMed ID: 10772627
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment.
    Engtrakul JJ; Foti RS; Strelevitz TJ; Fisher MB
    Drug Metab Dispos; 2005 Nov; 33(11):1621-7. PubMed ID: 16049128
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism.
    Court MH; Krishnaswamy S; Hao Q; Duan SX; Patten CJ; Von Moltke LL; Greenblatt DJ
    Drug Metab Dispos; 2003 Sep; 31(9):1125-33. PubMed ID: 12920168
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol.
    Chen M; LeDuc B; Kerr S; Howe D; Williams DA
    Drug Metab Dispos; 2010 Mar; 38(3):368-75. PubMed ID: 20008037
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine.
    Sun H; Zhang T; Wu Z; Wu B
    J Pharm Sci; 2015 Jan; 104(1):244-56. PubMed ID: 25393417
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.
    Manevski N; Moreolo PS; Yli-Kauhaluoma J; Finel M
    Drug Metab Dispos; 2011 Nov; 39(11):2117-29. PubMed ID: 21856742
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7.
    Bowalgaha K; Elliot DJ; Mackenzie PI; Knights KM; Miners JO
    Drug Metab Dispos; 2007 Mar; 35(3):363-70. PubMed ID: 17151189
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine.
    Bélanger AS; Caron P; Harvey M; Zimmerman PA; Mehlotra RK; Guillemette C
    Drug Metab Dispos; 2009 Sep; 37(9):1793-6. PubMed ID: 19487252
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Photoaffinity labeling of the aglycon binding site of the recombinant human liver UDP-glucuronosyltransferase UGT1A6 with 7-azido-4-methylcoumarin.
    Senay C; Battaglia E; Chen G; Breton R; Fournel-Gigleux S; Magdalou J; Radominska-Pandya A
    Arch Biochem Biophys; 1999 Aug; 368(1):75-84. PubMed ID: 10415114
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation.
    Uchaipichat V; Winner LK; Mackenzie PI; Elliot DJ; Williams JA; Miners JO
    Br J Clin Pharmacol; 2006 Apr; 61(4):427-39. PubMed ID: 16542204
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity.
    Nair PC; Chau N; McKinnon RA; Miners JO
    Mol Pharmacol; 2020 Dec; 98(6):710-718. PubMed ID: 33008919
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.