These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 18650448)

  • 1. Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface.
    Wakabayashi H; Varfaj F; Deangelis J; Fay PJ
    Blood; 2008 Oct; 112(7):2761-9. PubMed ID: 18650448
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa.
    Wakabayashi H; Fay PJ
    J Biol Chem; 2008 Apr; 283(17):11645-51. PubMed ID: 18299331
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity.
    Wakabayashi H; Fay PJ
    Biochemistry; 2013 Jun; 52(22):3921-9. PubMed ID: 23659383
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII.
    Wakabayashi H; Monaghan M; Fay PJ
    J Biol Chem; 2014 May; 289(20):14020-9. PubMed ID: 24692542
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability.
    Wakabayashi H; Griffiths AE; Fay PJ
    J Biol Chem; 2011 Jul; 286(29):25748-55. PubMed ID: 21628455
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations.
    Wakabayashi H; Griffiths AE; Fay PJ
    J Thromb Haemost; 2009 Mar; 7(3):438-44. PubMed ID: 19067791
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase.
    Wakabayashi H; Su YC; Ahmad SS; Walsh PN; Fay PJ
    Biochemistry; 2005 Aug; 44(30):10298-304. PubMed ID: 16042406
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit.
    Monaghan M; Wakabayashi H; Griffiths A; Wintermute J; Fay PJ
    Thromb Haemost; 2014 Sep; 112(3):495-502. PubMed ID: 24899227
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa.
    Jagannathan I; Ichikawa HT; Kruger T; Fay PJ
    J Biol Chem; 2009 Nov; 284(47):32248-55. PubMed ID: 19801661
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa.
    Lamphear BJ; Fay PJ
    Blood; 1992 Dec; 80(12):3120-6. PubMed ID: 1467518
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity.
    Regan LM; Fay PJ
    J Biol Chem; 1995 Apr; 270(15):8546-52. PubMed ID: 7721754
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain.
    Nogami K; Zhou Q; Myles T; Leung LL; Wakabayashi H; Fay PJ
    J Biol Chem; 2005 May; 280(18):18476-87. PubMed ID: 15746105
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity.
    Fay PJ; Smudzin TM; Walker FJ
    J Biol Chem; 1991 Oct; 266(30):20139-45. PubMed ID: 1939075
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Factor VIII A3 domain residues 1954-1961 represent an A1 domain-interactive site.
    Ansong C; Fay PJ
    Biochemistry; 2005 Jun; 44(24):8850-7. PubMed ID: 15952791
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII.
    Newell JL; Fay PJ
    Biochemistry; 2008 Aug; 47(33):8786-95. PubMed ID: 18642885
    [TBL] [Abstract][Full Text] [Related]  

  • 16. P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombin.
    Newell-Caito JL; Griffiths AE; Fay PJ
    Biochemistry; 2012 Apr; 51(16):3451-9. PubMed ID: 22455313
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Factor VIII A1 domain residues 97-105 represent a light chain-interactive site.
    Ansong C; Miles SM; Fay PJ
    Biochemistry; 2006 Nov; 45(44):13140-9. PubMed ID: 17073436
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Factor VIII lacking the C2 domain retains cofactor activity in vitro.
    Wakabayashi H; Griffiths AE; Fay PJ
    J Biol Chem; 2010 Aug; 285(33):25176-84. PubMed ID: 20529839
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa.
    Wakabayashi H; Fay PJ
    J Biol Chem; 2013 Oct; 288(43):31289-97. PubMed ID: 24030831
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proteolysis at Arg740 facilitates subsequent bond cleavages during thrombin-catalyzed activation of factor VIII.
    Newell JL; Fay PJ
    J Biol Chem; 2007 Aug; 282(35):25367-75. PubMed ID: 17595160
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.