These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 18662003)

  • 1. Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase.
    Ghosh AK; Kulkarni S
    Org Lett; 2008 Sep; 10(17):3907-9. PubMed ID: 18662003
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.
    Ying Y; Taori K; Kim H; Hong J; Luesch H
    J Am Chem Soc; 2008 Jul; 130(26):8455-9. PubMed ID: 18507379
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
    Bowers A; West N; Taunton J; Schreiber SL; Bradner JE; Williams RM
    J Am Chem Soc; 2008 Aug; 130(33):11219-22. PubMed ID: 18642817
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.
    Wang B; Huang PH; Chen CS; Forsyth CJ
    J Org Chem; 2011 Feb; 76(4):1140-50. PubMed ID: 21244075
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.
    Bowers AA; West N; Newkirk TL; Troutman-Youngman AE; Schreiber SL; Wiest O; Bradner JE; Williams RM
    Org Lett; 2009 Mar; 11(6):1301-4. PubMed ID: 19239241
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.
    Li S; Yao H; Xu J; Jiang S
    Molecules; 2011 Jun; 16(6):4681-94. PubMed ID: 21654576
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of class I HDAC isoform selectivity of largazole analogues.
    Kim B; Park H; Salvador LA; Serrano PE; Kwan JC; Zeller SL; Chen QY; Ryu S; Liu Y; Byeon S; Luesch H; Hong J
    Bioorg Med Chem Lett; 2014 Aug; 24(16):3728-31. PubMed ID: 25070421
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and activity of largazole analogues with linker and macrocycle modification.
    Ying Y; Liu Y; Byeon SR; Kim H; Luesch H; Hong J
    Org Lett; 2008 Sep; 10(18):4021-4. PubMed ID: 18707106
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
    Bhansali P; Hanigan CL; Casero RA; Tillekeratne LM
    J Med Chem; 2011 Nov; 54(21):7453-63. PubMed ID: 21936551
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of the thiazole-thiazoline fragment of largazole analogues.
    Diness F; Nielsen DS; Fairlie DP
    J Org Chem; 2011 Dec; 76(23):9845-51. PubMed ID: 22032297
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.
    Almaliti J; Al-Hamashi AA; Negmeldin AT; Hanigan CL; Perera L; Pflum MK; Casero RA; Tillekeratne LM
    J Med Chem; 2016 Dec; 59(23):10642-10660. PubMed ID: 27809521
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.
    Souto JA; Vaz E; Lepore I; Pöppler AC; Franci G; Alvarez R; Altucci L; de Lera AR
    J Med Chem; 2010 Jun; 53(12):4654-67. PubMed ID: 20491440
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A.
    Zhang B; Shan G; Zheng Y; Yu X; Ruan ZW; Li Y; Lei X
    Mar Drugs; 2019 Jun; 17(6):. PubMed ID: 31163697
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.
    Guerra-Bubb JM; Bowers AA; Smith WB; Paranal R; Estiu G; Wiest O; Bradner JE; Williams RM
    Bioorg Med Chem Lett; 2013 Nov; 23(21):6025-8. PubMed ID: 24035339
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.
    Clausen DJ; Smith WB; Haines BE; Wiest O; Bradner JE; Williams RM
    Bioorg Med Chem; 2015 Aug; 23(15):5061-5074. PubMed ID: 26054247
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of largazole zinc-binding group analogs.
    Kim B; Ratnayake R; Lee H; Shi G; Zeller SL; Li C; Luesch H; Hong J
    Bioorg Med Chem; 2017 Jun; 25(12):3077-3086. PubMed ID: 28416100
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.
    Benelkebir H; Marie S; Hayden AL; Lyle J; Loadman PM; Crabb SJ; Packham G; Ganesan A
    Bioorg Med Chem; 2011 Jun; 19(12):3650-8. PubMed ID: 21420302
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.
    Poli G; Di Fabio R; Ferrante L; Summa V; Botta M
    ChemMedChem; 2017 Dec; 12(23):1917-1926. PubMed ID: 29117473
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.
    Cole KE; Dowling DP; Boone MA; Phillips AJ; Christianson DW
    J Am Chem Soc; 2011 Aug; 133(32):12474-7. PubMed ID: 21790156
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluation of c7-demethyl largazole analogues.
    Chen F; Gao AH; Li J; Nan FJ
    ChemMedChem; 2009 Aug; 4(8):1269-72. PubMed ID: 19431162
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 9.