BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 18662878)

  • 1. 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
    Ellis DA; Blazel JK; Webber SE; Tran CV; Dragovich PS; Sun Z; Ruebsam F; McGuire HM; Xiang AX; Zhao J; Li LS; Zhou Y; Han Q; Kissinger CR; Showalter RE; Lardy M; Shah AM; Tsan M; Patel R; LeBrun LA; Kamran R; Bartkowski DM; Nolan TG; Norris DA; Sergeeva MV; Kirkovsky L
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4628-32. PubMed ID: 18662878
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
    Dragovich PS; Blazel JK; Ellis DA; Han Q; Kamran R; Kissinger CR; LeBrun LA; Li LS; Murphy DE; Noble M; Patel RA; Ruebsam F; Sergeeva MV; Shah AM; Showalter RE; Tran CV; Tsan M; Webber SE; Kirkovsky L; Zhou Y
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5635-9. PubMed ID: 18796353
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ruebsam F; Sun Z; Ayida BK; Webber SE; Zhou Y; Zhao Q; Kissinger CR; Showalter RE; Shah AM; Tsan M; Patel R; Lebrun LA; Kamran R; Sergeeva MV; Bartkowski DM; Nolan TG; Norris DA; Kirkovsky L
    Bioorg Med Chem Lett; 2008 Sep; 18(18):5002-5. PubMed ID: 18722768
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
    Li LS; Zhou Y; Murphy DE; Stankovic N; Zhao J; Dragovich PS; Bertolini T; Sun Z; Ayida B; Tran CV; Ruebsam F; Webber SE; Shah AM; Tsan M; Showalter RE; Patel R; Lebrun LA; Bartkowski DM; Nolan TG; Norris DA; Kamran R; Brooks J; Sergeeva MV; Kirkovsky L; Zhao Q; Kissinger CR
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3446-55. PubMed ID: 18457949
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ruebsam F; Webber SE; Tran MT; Tran CV; Murphy DE; Zhao J; Dragovich PS; Kim SH; Li LS; Zhou Y; Han Q; Kissinger CR; Showalter RE; Lardy M; Shah AM; Tsan M; Patel R; Lebrun LA; Kamran R; Sergeeva MV; Bartkowski DM; Nolan TG; Norris DA; Kirkovsky L
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3616-21. PubMed ID: 18487044
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
    Zhou Y; Li LS; Dragovich PS; Murphy DE; Tran CV; Ruebsam F; Webber SE; Shah AM; Tsan M; Averill A; Showalter RE; Patel R; Han Q; Zhao Q; Hermann T; Kissinger CR; Lebrun L; Sergeeva MV
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1419-24. PubMed ID: 18226901
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
    Sergeeva MV; Zhou Y; Bartkowski DM; Nolan TG; Norris DA; Okamoto E; Kirkovsky L; Kamran R; Lebrun LA; Tsan M; Patel R; Shah AM; Lardy M; Gobbi A; Li LS; Zhao J; Bertolini T; Stankovic N; Sun Z; Murphy DE; Webber SE; Dragovich PS
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3421-6. PubMed ID: 18442904
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
    Zhou Y; Webber SE; Murphy DE; Li LS; Dragovich PS; Tran CV; Sun Z; Ruebsam F; Shah AM; Tsan M; Showalter RE; Patel R; Li B; Zhao Q; Han Q; Hermann T; Kissinger CR; Lebrun L; Sergeeva MV; Kirkovsky L
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1413-8. PubMed ID: 18242088
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives.
    Wang G; Zhang L; Wu X; Das D; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4484-7. PubMed ID: 19497737
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.
    Kumar DV; Rai R; Brameld KA; Riggs J; Somoza JR; Rajagopalan R; Janc JW; Xia YM; Ton TL; Hu H; Lehoux I; Ho JD; Young WB; Hart B; Green MJ
    Bioorg Med Chem Lett; 2012 Jan; 22(1):300-4. PubMed ID: 22119470
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
    McGowan D; Nyanguile O; Cummings MD; Vendeville S; Vandyck K; Van den Broeck W; Boutton CW; De Bondt H; Quirynen L; Amssoms K; Bonfanti JF; Last S; Rombauts K; Tahri A; Hu L; Delouvroy F; Vermeiren K; Vandercruyssen G; Van der Helm L; Cleiren E; Mostmans W; Lory P; Pille G; Van Emelen K; Fanning G; Pauwels F; Lin TI; Simmen K; Raboisson P
    Bioorg Med Chem Lett; 2009 May; 19(9):2492-6. PubMed ID: 19342234
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
    Kim SH; Tran MT; Ruebsam F; Xiang AX; Ayida B; McGuire H; Ellis D; Blazel J; Tran CV; Murphy DE; Webber SE; Zhou Y; Shah AM; Tsan M; Showalter RE; Patel R; Gobbi A; LeBrun LA; Bartkowski DM; Nolan TG; Norris DA; Sergeeva MV; Kirkovsky L; Zhao Q; Han Q; Kissinger CR
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4181-5. PubMed ID: 18554907
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.
    Tedesco R; Chai D; Darcy MG; Dhanak D; Fitch DM; Gates A; Johnston VK; Keenan RM; Lin-Goerke J; Sarisky RT; Shaw AN; Valko KL; Wiggall KJ; Zimmerman MN; Duffy KJ
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4354-8. PubMed ID: 19505821
    [TBL] [Abstract][Full Text] [Related]  

  • 14. HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
    Wang G; Lei H; Wang X; Das D; Hong J; Mackinnon CH; Coulter TS; Montalbetti CA; Mears R; Gai X; Bailey SE; Ruhrmund D; Hooi L; Misialek S; Rajagopalan PT; Cheng RK; Barker JJ; Felicetti B; Schönfeld DL; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4480-3. PubMed ID: 19500983
    [TBL] [Abstract][Full Text] [Related]  

  • 15. HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
    Wang G; He Y; Sun J; Das D; Hu M; Huang J; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4476-9. PubMed ID: 19502055
    [TBL] [Abstract][Full Text] [Related]  

  • 16. II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.
    Anilkumar GN; Selyutin O; Rosenblum SB; Zeng Q; Jiang Y; Chan TY; Pu H; Wang L; Bennett F; Chen KX; Lesburg CA; Duca J; Gavalas S; Huang Y; Pinto P; Sannigrahi M; Velazquez F; Venkatraman S; Vibulbhan B; Agrawal S; Ferrari E; Jiang CK; Huang HC; Shih NY; George Njoroge F; Kozlowski JA
    Bioorg Med Chem Lett; 2012 Jan; 22(1):713-7. PubMed ID: 22104146
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Combined 3D-QSAR, molecular docking, molecular dynamics simulation, and binding free energy calculation studies on the 5-hydroxy-2H-pyridazin-3-one derivatives as HCV NS5B polymerase inhibitors.
    Yu H; Fang Y; Lu X; Liu Y; Zhang H
    Chem Biol Drug Des; 2014 Jan; 83(1):89-105. PubMed ID: 23941500
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Parallel solution-phase synthesis of 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1lambda6-benzo[1,4]thiazin-3-one derivatives from 1,5-difluoro-2,4-dinitrobenzene.
    Wang Z; Yuan Y; Chen Y; Sun G; Wu X; Zhang S; Han C; Wang G; Li L; Liu G
    J Comb Chem; 2007; 9(4):652-60. PubMed ID: 17503786
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
    Shaw AN; Tedesco R; Bambal R; Chai D; Concha NO; Darcy MG; Dhanak D; Duffy KJ; Fitch DM; Gates A; Johnston VK; Keenan RM; Lin-Goerke J; Liu N; Sarisky RT; Wiggall KJ; Zimmerman MN
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4350-3. PubMed ID: 19515564
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
    Hendricks RT; Fell JB; Blake JF; Fischer JP; Robinson JE; Spencer SR; Stengel PJ; Bernacki AL; Leveque VJ; Le Pogam S; Rajyaguru S; Najera I; Josey JA; Harris JR; Swallow S
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3637-41. PubMed ID: 19447623
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.