These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
278 related articles for article (PubMed ID: 18676143)
1. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Hansen JD; Grina J; Newhouse B; Welch M; Topalov G; Littman N; Callejo M; Gloor S; Martinson M; Laird E; Brandhuber BJ; Vigers G; Morales T; Woessner R; Randolph N; Lyssikatos J; Olivero A Bioorg Med Chem Lett; 2008 Aug; 18(16):4692-5. PubMed ID: 18676143 [TBL] [Abstract][Full Text] [Related]
2. Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors. Tang J; Hamajima T; Nakano M; Sato H; Dickerson SH; Lackey KE Bioorg Med Chem Lett; 2008 Aug; 18(16):4610-4. PubMed ID: 18662874 [TBL] [Abstract][Full Text] [Related]
3. Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity. Lyne PD; Aquila B; Cook DJ; Dakin LA; Ezhuthachan J; Ioannidis S; Pontz T; Su M; Ye Q; Zheng X; Block MH; Cowen S; Deegan TL; Lee JW; Scott DA; Custeau D; Drew L; Poondru S; Shen M; Wu A Bioorg Med Chem Lett; 2009 Feb; 19(3):1026-9. PubMed ID: 19097792 [TBL] [Abstract][Full Text] [Related]
4. Dual binding site inhibitors of B-RAF kinase. Wolin RL; Bembenek SD; Wei J; Crawford S; Lundeen K; Brunmark A; Karlsson L; Edwards JP; Blevitt JM Bioorg Med Chem Lett; 2008 May; 18(9):2825-9. PubMed ID: 18434146 [TBL] [Abstract][Full Text] [Related]
5. Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors. Packard GK; Papa P; Riggs JR; Erdman P; Tehrani L; Robinson D; Harris R; Shevlin G; Perrin-Ninkovic S; Hilgraf R; McCarrick MA; Tran T; Fleming Y; Bai A; Richardson S; Katz J; Tang Y; Leisten J; Moghaddam M; Cathers B; Zhu D; Sakata S Bioorg Med Chem Lett; 2012 Jan; 22(1):747-52. PubMed ID: 22137342 [TBL] [Abstract][Full Text] [Related]
6. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Berger DM; Torres N; Dutia M; Powell D; Ciszewski G; Gopalsamy A; Levin JI; Kim KH; Xu W; Wilhelm J; Hu Y; Collins K; Feldberg L; Kim S; Frommer E; Wojciechowicz D; Mallon R Bioorg Med Chem Lett; 2009 Dec; 19(23):6519-23. PubMed ID: 19864136 [TBL] [Abstract][Full Text] [Related]
7. Non-oxime pyrazole based inhibitors of B-Raf kinase. Newhouse BJ; Hansen JD; Grina J; Welch M; Topalov G; Littman N; Callejo M; Martinson M; Galbraith S; Laird ER; Brandhuber BJ; Vigers G; Morales T; Woessner R; Randolph N; Lyssikatos J; Olivero A Bioorg Med Chem Lett; 2011 Jun; 21(11):3488-92. PubMed ID: 21536432 [TBL] [Abstract][Full Text] [Related]
8. The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase. Ren L; Ahrendt KA; Grina J; Laird ER; Buckmelter AJ; Hansen JD; Newhouse B; Moreno D; Wenglowsky S; Dinkel V; Gloor SL; Hastings G; Rana S; Rasor K; Risom T; Sturgis HL; Voegtli WC; Mathieu S Bioorg Med Chem Lett; 2012 May; 22(10):3387-91. PubMed ID: 22534450 [TBL] [Abstract][Full Text] [Related]
9. Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. Smith AL; DeMorin FF; Paras NA; Huang Q; Petkus JK; Doherty EM; Nixey T; Kim JL; Whittington DA; Epstein LF; Lee MR; Rose MJ; Babij C; Fernando M; Hess K; Le Q; Beltran P; Carnahan J J Med Chem; 2009 Oct; 52(20):6189-92. PubMed ID: 19764794 [TBL] [Abstract][Full Text] [Related]
10. Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties. Ren L; Laird ER; Buckmelter AJ; Dinkel V; Gloor SL; Grina J; Newhouse B; Rasor K; Hastings G; Gradl SN; Rudolph J Bioorg Med Chem Lett; 2012 Jan; 22(2):1165-8. PubMed ID: 22196124 [TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors. Ramurthy S; Subramanian S; Aikawa M; Amiri P; Costales A; Dove J; Fong S; Jansen JM; Levine B; Ma S; McBride CM; Michaelian J; Pick T; Poon DJ; Girish S; Shafer CM; Stuart D; Sung L; Renhowe PA J Med Chem; 2008 Nov; 51(22):7049-52. PubMed ID: 18942827 [TBL] [Abstract][Full Text] [Related]
13. Discovery of highly potent and selective type I B-Raf kinase inhibitors. Wang X; Berger DM; Salaski EJ; Torres N; Hu Y; Levin JI; Powell D; Wojciechowicz D; Collins K; Frommer E Bioorg Med Chem Lett; 2009 Dec; 19(23):6571-4. PubMed ID: 19854649 [TBL] [Abstract][Full Text] [Related]
14. Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors. Dietrich J; Gokhale V; Wang X; Hurley LH; Flynn GA Bioorg Med Chem; 2010 Jan; 18(1):292-304. PubMed ID: 19962319 [TBL] [Abstract][Full Text] [Related]