195 related articles for article (PubMed ID: 18680273)
1. Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication.
Yedavalli VS; Zhang N; Cai H; Zhang P; Starost MF; Hosmane RS; Jeang KT
J Med Chem; 2008 Aug; 51(16):5043-51. PubMed ID: 18680273
[TBL] [Abstract][Full Text] [Related]
2. NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.
Xie M; Vesuna F; Botlagunta M; Bol GM; Irving A; Bergman Y; Hosmane RS; Kato Y; Winnard PT; Raman V
Oncotarget; 2015 Oct; 6(30):29901-13. PubMed ID: 26337079
[TBL] [Abstract][Full Text] [Related]
3. Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5-e][1,3]diazepine ring system. In vitro results and implications.
Zhang N; Zhang P; Baier A; Cova L; Hosmane RS
Bioorg Med Chem Lett; 2014 Feb; 24(4):1154-7. PubMed ID: 24461293
[TBL] [Abstract][Full Text] [Related]
4. DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs.
Kukhanova MK; Karpenko IL; Ivanov AV
Molecules; 2020 Feb; 25(4):. PubMed ID: 32102413
[TBL] [Abstract][Full Text] [Related]
5. Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.
Zhang N; Chen HM; Koch V; Schmitz H; Liao CL; Bretner M; Bhadti VS; Fattom AI; Naso RB; Hosmane RS; Borowski P
J Med Chem; 2003 Sep; 46(19):4149-64. PubMed ID: 12954067
[TBL] [Abstract][Full Text] [Related]
6. Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir.
Rao S; Lungu C; Crespo R; Steijaert TH; Gorska A; Palstra RJ; Prins HAB; van Ijcken W; Mueller YM; van Kampen JJA; Verbon A; Katsikis PD; Boucher CAB; Rokx C; Gruters RA; Mahmoudi T
Nat Commun; 2021 Apr; 12(1):2475. PubMed ID: 33931637
[TBL] [Abstract][Full Text] [Related]
7. Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.
Radi M; Falchi F; Garbelli A; Samuele A; Bernardo V; Paolucci S; Baldanti F; Schenone S; Manetti F; Maga G; Botta M
Bioorg Med Chem Lett; 2012 Mar; 22(5):2094-8. PubMed ID: 22300661
[TBL] [Abstract][Full Text] [Related]
8. Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.
Maga G; Falchi F; Radi M; Botta L; Casaluce G; Bernardini M; Irannejad H; Manetti F; Garbelli A; Samuele A; Zanoli S; Esté JA; Gonzalez E; Zucca E; Paolucci S; Baldanti F; De Rijck J; Debyser Z; Botta M
ChemMedChem; 2011 Aug; 6(8):1371-89. PubMed ID: 21698775
[TBL] [Abstract][Full Text] [Related]
9. Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.
Maga G; Falchi F; Garbelli A; Belfiore A; Witvrouw M; Manetti F; Botta M
J Med Chem; 2008 Nov; 51(21):6635-8. PubMed ID: 18834110
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase.
Ludek OR; Schroeder GK; Wolfenden R; Marquez VE
Nucleic Acids Symp Ser (Oxf); 2008; (52):659-60. PubMed ID: 18776552
[TBL] [Abstract][Full Text] [Related]
11. Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis.
Ishaq M; Hu J; Wu X; Fu Q; Yang Y; Liu Q; Guo D
Mol Biotechnol; 2008 Jul; 39(3):231-8. PubMed ID: 18259889
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation.
Aksenova M; Sybrandt J; Cui B; Sikirzhytski V; Ji H; Odhiambo D; Lucius MD; Turner JR; Broude E; Peña E; Lizarraga S; Zhu J; Safro I; Wyatt MD; Shtutman M
J Neuroimmune Pharmacol; 2020 Jun; 15(2):209-223. PubMed ID: 31802418
[TBL] [Abstract][Full Text] [Related]
13. Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.
Borowski P; Lang M; Haag A; Schmitz H; Choe J; Chen HM; Hosmane RS
Antimicrob Agents Chemother; 2002 May; 46(5):1231-9. PubMed ID: 11959550
[TBL] [Abstract][Full Text] [Related]
14. Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus.
Bridges EG; Dutschman GE; Gullen EA; Cheng YC
Biochem Pharmacol; 1996 Mar; 51(6):731-6. PubMed ID: 8602867
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and anti-HIV activity of different novel nonclassical nucleosides.
Elgemeie GE; Mansour OA; Metwally NH
Nucleosides Nucleotides; 1999 Jan; 18(1):113-23. PubMed ID: 10048227
[TBL] [Abstract][Full Text] [Related]
16. Effect of acyclic nucleoside phosphonates on the HIV-1 integrase in vitro.
Abu Sheika G; Tramontano E; Loi AG; Franchetti P; Grifantini M; La Colla P
Nucleosides Nucleotides; 1999; 18(4-5):849-51. PubMed ID: 10432692
[TBL] [Abstract][Full Text] [Related]
17. Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity.
Winter H; Maeda Y; Uchida H; Mitsuya H; Zemlicka J
J Med Chem; 1997 Jul; 40(14):2191-5. PubMed ID: 9216838
[TBL] [Abstract][Full Text] [Related]
18. Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Cui BC; Sikirzhytski V; Aksenova M; Lucius MD; Levon GH; Mack ZT; Pollack C; Odhiambo D; Broude E; Lizarraga SB; Wyatt MD; Shtutman M
Biochem Pharmacol; 2020 Dec; 182():114280. PubMed ID: 33049245
[TBL] [Abstract][Full Text] [Related]
19. Structure and biological activity correlation for some nucleoside analogues-inhibitors of reproduction of human immunodeficiency virus (HIV-1).
Gurskaya GV; Bochkarev AV; Tsapkina EN; Zdanov AS; Krayevsky AA
Nucleic Acids Symp Ser; 1991; (24):241. PubMed ID: 1841310
[No Abstract] [Full Text] [Related]
20. Substrate/inhibition studies of bacteriophage T7 RNA polymerase with the 5'-triphosphate derivative of a ring-expanded ('fat') nucleoside possessing potent antiviral and anticancer activities.
Bretner M; Beckett TD; Sood RK; Baldisseri DM; Hosmane RS
Bioorg Med Chem; 1999 Dec; 7(12):2931-6. PubMed ID: 10658598
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
