293 related articles for article (PubMed ID: 18682323)
1. Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
Berglund S; Egner BJ; Gradén H; Gradén J; Morgan DG; Inghardt T; Giordanetto F
Bioorg Med Chem Lett; 2008 Sep; 18(17):4859-63. PubMed ID: 18682323
[TBL] [Abstract][Full Text] [Related]
2. Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.
Ando M; Sekino E; Haga Y; Moriya M; Ito M; Ito J; Iwaasa H; Ishihara A; Kanatani A; Ohtake N
Bioorg Med Chem Lett; 2009 Sep; 19(17):5186-90. PubMed ID: 19632840
[TBL] [Abstract][Full Text] [Related]
3. Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.
Suzuki T; Kameda M; Ando M; Miyazoe H; Sekino E; Ito S; Masutani K; Kamijo K; Takezawa A; Moriya M; Ito M; Ito J; Nakase K; Matsushita H; Ishihara A; Takenaga N; Tokita S; Kanatani A; Sato N; Fukami T
Bioorg Med Chem Lett; 2009 Sep; 19(18):5339-45. PubMed ID: 19683441
[TBL] [Abstract][Full Text] [Related]
4. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
Suzuki T; Moriya M; Sakamoto T; Suga T; Kishino H; Takahashi H; Ishikawa M; Nagai K; Imai Y; Sekino E; Ito M; Iwaasa H; Ishihara A; Tokita S; Kanatani A; Sato N; Fukami T
Bioorg Med Chem Lett; 2009 Jun; 19(11):3072-7. PubMed ID: 19403308
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
Lim CJ; Kim N; Lee EK; Lee BH; Oh KS; Yoo SE; Yi KY
Bioorg Med Chem Lett; 2011 Apr; 21(8):2309-12. PubMed ID: 21420863
[TBL] [Abstract][Full Text] [Related]
6. Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.
Souers AJ; Gao J; Brune M; Bush E; Wodka D; Vasudevan A; Judd AS; Mulhern M; Brodjian S; Dayton B; Shapiro R; Hernandez LE; Marsh KC; Sham HL; Collins CA; Kym PR
J Med Chem; 2005 Mar; 48(5):1318-21. PubMed ID: 15743174
[TBL] [Abstract][Full Text] [Related]
7. Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.
Ma V; Bannon AW; Baumgartner J; Hale C; Hsieh F; Hulme C; Rorrer K; Salon J; van Staden C; Tempest P
Bioorg Med Chem Lett; 2006 Oct; 16(19):5066-72. PubMed ID: 16887348
[TBL] [Abstract][Full Text] [Related]
8. Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
Sasmal PK; Sasmal S; Rao PT; Venkatesham B; Roshaiah M; Abbineni C; Khanna I; Jadhav VP; Suresh J; Talwar R; Muzeeb S; Receveur JM; Frimurer TM; Rist Ø; Elster L; Högberg T
Bioorg Med Chem Lett; 2010 Sep; 20(18):5443-8. PubMed ID: 20724156
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.
Lim CJ; Kim JY; Lee BH; Oh KS; Yi KY
Bioorg Med Chem Lett; 2013 Mar; 23(6):1736-9. PubMed ID: 23411080
[TBL] [Abstract][Full Text] [Related]
10. Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists.
Giordanetto F; Karlsson O; Lindberg J; Larsson LO; Linusson A; Evertsson E; Morgan DG; Inghardt T
Bioorg Med Chem Lett; 2007 Aug; 17(15):4232-41. PubMed ID: 17532215
[TBL] [Abstract][Full Text] [Related]
11. A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
Clark DE; Higgs C; Wren SP; Dyke HJ; Wong M; Norman D; Lockey PM; Roach AG
J Med Chem; 2004 Jul; 47(16):3962-71. PubMed ID: 15267235
[TBL] [Abstract][Full Text] [Related]
12. SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.
Witty DR; Bateson JH; Hervieu GJ; Jeffrey P; Johnson CN; Muir AI; O'Hanlon PJ; Stemp G; Stevens AJ; Thewlis KM; Wilson S; Winborn KY
Bioorg Med Chem Lett; 2006 Sep; 16(18):4865-71. PubMed ID: 16839761
[TBL] [Abstract][Full Text] [Related]
13. Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.
Sasikumar TK; Qiang L; Burnett DA; Greenlee WJ; Hawes BE; Kowalski TJ; O'Neill K; Spar BD; Weig B
Bioorg Med Chem Lett; 2006 Oct; 16(20):5427-31. PubMed ID: 16889961
[TBL] [Abstract][Full Text] [Related]
14. Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.
Galiano S; Ceras J; Cirauqui N; Pérez S; Juanenea L; Rivera G; Aldana I; Monge A
Bioorg Med Chem; 2007 Jun; 15(11):3896-911. PubMed ID: 17407817
[TBL] [Abstract][Full Text] [Related]
15. New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Cirauqui N; Ceras J; Galiano S; Pérez-Silanes S; Juanenea L; Rivera G; Aldana I; Monge A
Arzneimittelforschung; 2008; 58(11):585-91. PubMed ID: 19137910
[TBL] [Abstract][Full Text] [Related]
16. Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.
Semple G; Tran TA; Kramer B; Hsu D; Han S; Choi J; Vallar P; Casper MD; Zou N; Hauser EK; Thomsen W; Whelan K; Sengupta D; Morgan M; Sekiguchi Y; Kanuma K; Chaki S; Grottick AJ
Bioorg Med Chem Lett; 2009 Nov; 19(21):6166-71. PubMed ID: 19773162
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Rowbottom MW; Vickers TD; Tamiya J; Zhang M; Dyck B; Grey J; Schwarz D; Heise CE; Hedrick M; Wen J; Tang H; Wang H; Fisher A; Aparicio A; Saunders J; Goodfellow VS
Bioorg Med Chem Lett; 2007 Apr; 17(8):2171-8. PubMed ID: 17350839
[TBL] [Abstract][Full Text] [Related]
18. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
McBriar MD; Guzik H; Shapiro S; Paruchova J; Xu R; Palani A; Clader JW; Cox K; Greenlee WJ; Hawes BE; Kowalski TJ; O'neill K; Spar BD; Weig B; Weston DJ; Farley C; Cook J
J Med Chem; 2006 Apr; 49(7):2294-310. PubMed ID: 16570926
[TBL] [Abstract][Full Text] [Related]
19. Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.
Witty DR; Bateson J; Hervieu GJ; Al-Barazanji K; Jeffrey P; Hamprecht D; Haynes A; Johnson CN; Muir AI; O'Hanlon PJ; Stemp G; Stevens AJ; Thewlis K; Winborn KY
Bioorg Med Chem Lett; 2006 Sep; 16(18):4872-8. PubMed ID: 16839763
[TBL] [Abstract][Full Text] [Related]
20. 6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist.
Tavares FX; Al-Barazanji KA; Bishop MJ; Britt CS; Carlton DL; Cooper JP; Feldman PL; Garrido DM; Goetz AS; Grizzle MK; Hertzog DL; Ignar DM; Lang DG; McIntyre MS; Ott RJ; Peat AJ; Zhou HQ
J Med Chem; 2006 Nov; 49(24):7108-18. PubMed ID: 17125263
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
