BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 18686942)

  • 1. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
    DeMartino JK; Hwang I; Connelly S; Wilson IA; Boger DL
    J Med Chem; 2008 Sep; 51(17):5441-8. PubMed ID: 18686942
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH; Labroli MA; Hedrick MP; Jin Q; Desharnais J; Baker SJ; Gooljarsingh LT; Ramcharan J; Tavassoli A; Zhang Y; Wilson IA; Beardsley GP; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2002 Aug; 10(8):2739-49. PubMed ID: 12057663
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.
    Connelly S; DeMartino JK; Boger DL; Wilson IA
    Biochemistry; 2013 Jul; 52(30):5133-44. PubMed ID: 23869564
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.
    DeMartino JK; Hwang I; Xu L; Wilson IA; Boger DL
    J Med Chem; 2006 May; 49(10):2998-3002. PubMed ID: 16686541
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H; Chong Y; Hwang I; Tavassoli A; Zhang Y; Wilson IA; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2005 May; 13(10):3577-85. PubMed ID: 15848770
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Desharnais J; Hwang I; Zhang Y; Tavassoli A; Baboval J; Benkovic SJ; Wilson IA; Boger DL
    Bioorg Med Chem; 2003 Oct; 11(20):4511-21. PubMed ID: 13129587
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH; Hedrick MP; Desharnais J; Capps K; Tavassoli A; Zhang Y; Wilson IA; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2003 Oct; 11(20):4503-9. PubMed ID: 13129586
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y; Desharnais J; Marsilje TH; Li C; Hedrick MP; Gooljarsingh LT; Tavassoli A; Benkovic SJ; Olson AJ; Boger DL; Wilson IA
    Biochemistry; 2003 May; 42(20):6043-56. PubMed ID: 12755606
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.
    Chong Y; Hwang I; Tavassoli A; Zhang Y; Wilson IA; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2005 May; 13(10):3587-92. PubMed ID: 15848771
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
    Cheng H; Hwang I; Chong Y; Tavassoli A; Webb ME; Zhang Y; Wilson IA; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2005 May; 13(10):3593-9. PubMed ID: 15848772
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Marsilje TH; Hedrick MP; Desharnais J; Tavassoli A; Zhang Y; Wilson IA; Benkovic SJ; Boger DL
    Bioorg Med Chem; 2003 Oct; 11(20):4487-501. PubMed ID: 13129585
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL; Haynes NE; Kitos PA; Warren MS; Ramcharan J; Marolewski AE; Benkovic SJ
    Bioorg Med Chem; 1997 Sep; 5(9):1817-30. PubMed ID: 9354237
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL; Haynes NE; Warren MS; Ramcharan J; Marolewski AE; Kitos PA; Benkovic SJ
    Bioorg Med Chem; 1997 Sep; 5(9):1847-52. PubMed ID: 9354240
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
    Wallace-Povirk A; Tong N; Wong-Roushar J; O'Connor C; Zhou X; Hou Z; Bao X; Garcia GE; Li J; Kim S; Dann CE; Matherly LH; Gangjee A
    Bioorg Med Chem; 2021 May; 37():116093. PubMed ID: 33773393
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Boger DL; Marsilje TH; Castro RA; Hedrick MP; Jin Q; Baker SJ; Shim JH; Benkovic SJ
    Bioorg Med Chem Lett; 2000 Jul; 10(13):1471-5. PubMed ID: 10888335
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
    Greasley SE; Marsilje TH; Cai H; Baker S; Benkovic SJ; Boger DL; Wilson IA
    Biochemistry; 2001 Nov; 40(45):13538-47. PubMed ID: 11695901
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A quantum chemical study on the mechanism of glycinamide ribonucleotide transformylase inhibitor: 10-Formyl-5,8,10-trideazafolic acid.
    Qiao QA; Jin Y; Yang C; Zhang Z; Wang M
    Biophys Chem; 2005 Dec; 118(2-3):78-83. PubMed ID: 16198047
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
    Rosowsky A; Forsch RA; Reich VE; Freisheim JH; Moran RG
    J Med Chem; 1992 May; 35(9):1578-88. PubMed ID: 1578484
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
    Zhang Y; Desharnais J; Greasley SE; Beardsley GP; Boger DL; Wilson IA
    Biochemistry; 2002 Dec; 41(48):14206-15. PubMed ID: 12450384
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.
    Itoh F; Russello O; Akimoto H; Beardsley GP
    Cancer Chemother Pharmacol; 1994; 34(4):273-9. PubMed ID: 8033293
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.