These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
136 related articles for article (PubMed ID: 18690714)
1. Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. Boehr DD; Dyson HJ; Wright PE Biochemistry; 2008 Sep; 47(35):9227-33. PubMed ID: 18690714 [TBL] [Abstract][Full Text] [Related]
2. Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway. Oyen D; Fenwick RB; Stanfield RL; Dyson HJ; Wright PE J Am Chem Soc; 2015 Jul; 137(29):9459-68. PubMed ID: 26147643 [TBL] [Abstract][Full Text] [Related]
3. Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. Oyen D; Fenwick RB; Aoto PC; Stanfield RL; Wilson IA; Dyson HJ; Wright PE J Am Chem Soc; 2017 Aug; 139(32):11233-11240. PubMed ID: 28737940 [TBL] [Abstract][Full Text] [Related]
4. Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. Wong KF; Selzer T; Benkovic SJ; Hammes-Schiffer S Proc Natl Acad Sci U S A; 2005 May; 102(19):6807-12. PubMed ID: 15811945 [TBL] [Abstract][Full Text] [Related]
5. Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate. Khavrutskii IV; Price DJ; Lee J; Brooks CL Protein Sci; 2007 Jun; 16(6):1087-100. PubMed ID: 17473015 [TBL] [Abstract][Full Text] [Related]
6. High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP Nagae T; Yamada H; Watanabe N Acta Crystallogr D Struct Biol; 2018 Sep; 74(Pt 9):895-905. PubMed ID: 30198899 [TBL] [Abstract][Full Text] [Related]
7. Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes. Osborne MJ; Venkitakrishnan RP; Dyson HJ; Wright PE Protein Sci; 2003 Oct; 12(10):2230-8. PubMed ID: 14500880 [TBL] [Abstract][Full Text] [Related]
8. Correlated motion and the effect of distal mutations in dihydrofolate reductase. Rod TH; Radkiewicz JL; Brooks CL Proc Natl Acad Sci U S A; 2003 Jun; 100(12):6980-5. PubMed ID: 12756296 [TBL] [Abstract][Full Text] [Related]
9. Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100. Liu CT; Francis K; Layfield JP; Huang X; Hammes-Schiffer S; Kohen A; Benkovic SJ Proc Natl Acad Sci U S A; 2014 Dec; 111(51):18231-6. PubMed ID: 25453098 [TBL] [Abstract][Full Text] [Related]
10. Preservation of protein dynamics in dihydrofolate reductase evolution. Francis K; Stojkovic V; Kohen A J Biol Chem; 2013 Dec; 288(50):35961-8. PubMed ID: 24158440 [TBL] [Abstract][Full Text] [Related]
11. Solution Ionic Strength Can Modulate Functional Loop Conformations in Babu CS; Chen JY; Lim C J Phys Chem B; 2024 May; 128(17):4111-4122. PubMed ID: 38651832 [TBL] [Abstract][Full Text] [Related]
12. Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase. Arora K; Brooks CL Top Curr Chem; 2013; 337():165-87. PubMed ID: 23420416 [TBL] [Abstract][Full Text] [Related]
13. Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases. Luk LY; Loveridge EJ; Allemann RK J Am Chem Soc; 2014 May; 136(19):6862-5. PubMed ID: 24779446 [TBL] [Abstract][Full Text] [Related]
14. Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase. Pu J; Ma S; Garcia-Viloca M; Gao J; Truhlar DG; Kohen A J Am Chem Soc; 2005 Oct; 127(42):14879-86. PubMed ID: 16231943 [TBL] [Abstract][Full Text] [Related]
16. Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. Hammes GG; Benkovic SJ; Hammes-Schiffer S Biochemistry; 2011 Dec; 50(48):10422-30. PubMed ID: 22029278 [TBL] [Abstract][Full Text] [Related]
17. Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Greisman JB; Dalton KM; Brookner DE; Klureza MA; Sheehan CJ; Kim IS; Henning RW; Russi S; Hekstra DR Proc Natl Acad Sci U S A; 2024 Feb; 121(9):e2313192121. PubMed ID: 38386706 [TBL] [Abstract][Full Text] [Related]
18. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. Wang Z; Sapienza PJ; Abeysinghe T; Luzum C; Lee AL; Finer-Moore JS; Stroud RM; Kohen A J Am Chem Soc; 2013 May; 135(20):7583-92. PubMed ID: 23611499 [TBL] [Abstract][Full Text] [Related]
19. Quantifying the limits of transition state theory in enzymatic catalysis. Zinovjev K; Tuñón I Proc Natl Acad Sci U S A; 2017 Nov; 114(47):12390-12395. PubMed ID: 29101125 [TBL] [Abstract][Full Text] [Related]
20. Cryo-kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase. Adesina AS; Luk LYP; Allemann RK Chembiochem; 2021 Jul; 22(14):2410-2414. PubMed ID: 33876533 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]