BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

197 related articles for article (PubMed ID: 18698753)

  • 1. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.
    Oumata N; Bettayeb K; Ferandin Y; Demange L; Lopez-Giral A; Goddard ML; Myrianthopoulos V; Mikros E; Flajolet M; Greengard P; Meijer L; Galons H
    J Med Chem; 2008 Sep; 51(17):5229-42. PubMed ID: 18698753
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors.
    N'gompaza-Diarra J; Bettayeb K; Gresh N; Meijer L; Oumata N
    Eur J Med Chem; 2012 Oct; 56():210-6. PubMed ID: 22982525
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.
    Demange L; Abdellah FN; Lozach O; Ferandin Y; Gresh N; Meijer L; Galons H
    Bioorg Med Chem Lett; 2013 Jan; 23(1):125-31. PubMed ID: 23218601
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
    Meijer L; Borgne A; Mulner O; Chong JP; Blow JJ; Inagaki N; Inagaki M; Delcros JG; Moulinoux JP
    Eur J Biochem; 1997 Jan; 243(1-2):527-36. PubMed ID: 9030781
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I.
    Trova MP; Barnes KD; Barford C; Benanti T; Bielaska M; Burry L; Lehman JM; Murphy C; O'Grady H; Peace D; Salamone S; Smith J; Snider P; Toporowski J; Tregay S; Wilson A; Wyle M; Zheng X; Friedrich TD
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6608-12. PubMed ID: 19846305
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
    De Azevedo WF; Leclerc S; Meijer L; Havlicek L; Strnad M; Kim SH
    Eur J Biochem; 1997 Jan; 243(1-2):518-26. PubMed ID: 9030780
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
    Leclerc S; Garnier M; Hoessel R; Marko D; Bibb JA; Snyder GL; Greengard P; Biernat J; Wu YZ; Mandelkow EM; Eisenbrand G; Meijer L
    J Biol Chem; 2001 Jan; 276(1):251-60. PubMed ID: 11013232
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents.
    Houzé S; Hoang NT; Lozach O; Le Bras J; Meijer L; Galons H; Demange L
    Molecules; 2014 Sep; 19(9):15237-57. PubMed ID: 25251193
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.
    Zatloukal M; Jorda R; Gucký T; Řezníčková E; Voller J; Pospíšil T; Malínková V; Adamcová H; Kryštof V; Strnad M
    Eur J Med Chem; 2013 Mar; 61():61-72. PubMed ID: 22770608
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
    Bettayeb K; Oumata N; Echalier A; Ferandin Y; Endicott JA; Galons H; Meijer L
    Oncogene; 2008 Oct; 27(44):5797-807. PubMed ID: 18574471
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
    Delehouzé C; Godl K; Loaëc N; Bruyère C; Desban N; Oumata N; Galons H; Roumeliotis TI; Giannopoulou EG; Grenet J; Twitchell D; Lahti J; Mouchet N; Galibert MD; Garbis SD; Meijer L
    Oncogene; 2014 Dec; 33(50):5675-87. PubMed ID: 24317512
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex.
    Legraverend M; Tunnah P; Noble M; Ducrot P; Ludwig O; Grierson DS; Leost M; Meijer L; Endicott J
    J Med Chem; 2000 Apr; 43(7):1282-92. PubMed ID: 10753466
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.
    Legraverend M; Ludwig O; Bisagni E; Leclerc S; Meijer L; Giocanti N; Sadri R; Favaudon V
    Bioorg Med Chem; 1999 Jul; 7(7):1281-93. PubMed ID: 10465404
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and structural-functional analysis of cyclin-dependent kinases of the cattle tick Rhipicephalus (Boophilus) microplus.
    Gomes H; Romeiro NC; Braz GR; de Oliveira EA; Rodrigues C; da Fonseca RN; Githaka N; Isezaki M; Konnai S; Ohashi K; da Silva Vaz I; Logullo C; Moraes J
    PLoS One; 2013; 8(10):e76128. PubMed ID: 24146826
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.
    Jorda R; Havlícek L; McNae IW; Walkinshaw MD; Voller J; Sturc A; Navrátilová J; Kuzma M; Mistrík M; Bártek J; Strnad M; Krystof V
    J Med Chem; 2011 Apr; 54(8):2980-93. PubMed ID: 21417417
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases.
    Liebl J; Krystof V; Vereb G; Takács L; Strnad M; Pechan P; Havlicek L; Zatloukal M; Fürst R; Vollmar AM; Zahler S
    Angiogenesis; 2011 Sep; 14(3):281-91. PubMed ID: 21487803
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II.
    Trova MP; Barnes KD; Alicea L; Benanti T; Bielaska M; Bilotta J; Bliss B; Duong TN; Haydar S; Herr RJ; Hui Y; Johnson M; Lehman JM; Peace D; Rainka M; Snider P; Salamone S; Tregay S; Zheng X; Friedrich TD
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6613-7. PubMed ID: 19854650
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism of CDK5/p25 binding by CDK inhibitors.
    Mapelli M; Massimiliano L; Crovace C; Seeliger MA; Tsai LH; Meijer L; Musacchio A
    J Med Chem; 2005 Feb; 48(3):671-9. PubMed ID: 15689152
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular model of cyclin-dependent kinase 5 complexed with roscovitine.
    Filgueira de Azevedo W; Gaspar RT; Canduri F; Camera JC; Freitas da Silveira NJ
    Biochem Biophys Res Commun; 2002 Oct; 297(5):1154-8. PubMed ID: 12372407
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
    Wilson SC; Atrash B; Barlow C; Eccles S; Fischer PM; Hayes A; Kelland L; Jackson W; Jarman M; Mirza A; Moreno J; Nutley BP; Raynaud FI; Sheldrake P; Walton M; Westwood R; Whittaker S; Workman P; McDonald E
    Bioorg Med Chem; 2011 Nov; 19(22):6949-65. PubMed ID: 21982796
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.