These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
143 related articles for article (PubMed ID: 18703847)
1. Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Cody V; Pace J; Rosowsky A Acta Crystallogr D Biol Crystallogr; 2008 Sep; 64(Pt 9):977-84. PubMed ID: 18703847 [TBL] [Abstract][Full Text] [Related]
2. Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Cody V; Pace J; Nowak J Acta Crystallogr D Biol Crystallogr; 2011 Oct; 67(Pt 10):875-80. PubMed ID: 21931219 [TBL] [Abstract][Full Text] [Related]
3. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Cody V; Pace J; Chisum K; Rosowsky A Proteins; 2006 Dec; 65(4):959-69. PubMed ID: 17019704 [TBL] [Abstract][Full Text] [Related]
4. Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Cody V; Galitsky N; Luft JR; Pangborn W; Rosowsky A; Queener SF Acta Crystallogr D Biol Crystallogr; 2002 Jun; 58(Pt 6 Pt 2):946-54. PubMed ID: 12037296 [TBL] [Abstract][Full Text] [Related]
5. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Cody V; Pace J; Namjoshi OA; Gangjee A Acta Crystallogr F Struct Biol Commun; 2015 Jun; 71(Pt 6):799-803. PubMed ID: 26057816 [TBL] [Abstract][Full Text] [Related]
6. Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase. Rosowsky A; Fu H; Chan DC; Queener SF J Med Chem; 2004 May; 47(10):2475-85. PubMed ID: 15115391 [TBL] [Abstract][Full Text] [Related]
7. Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain. Rosowsky A; Cody V; Galitsky N; Fu H; Papoulis AT; Queener SF J Med Chem; 1999 Nov; 42(23):4853-60. PubMed ID: 10579848 [TBL] [Abstract][Full Text] [Related]
8. Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Cody V; Chan D; Galitsky N; Rak D; Luft JR; Pangborn W; Queener SF; Laughton CA; Stevens MF Biochemistry; 2000 Apr; 39(13):3556-64. PubMed ID: 10736154 [TBL] [Abstract][Full Text] [Related]
9. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Cody V; Galitsky N; Luft JR; Pangborn W; Queener SF; Gangjee A Acta Crystallogr D Biol Crystallogr; 2002 Sep; 58(Pt 9):1393-9. PubMed ID: 12198294 [TBL] [Abstract][Full Text] [Related]
10. Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives. Cody V; Pace J Acta Crystallogr D Biol Crystallogr; 2011 Jan; 67(Pt 1):1-7. PubMed ID: 21206056 [TBL] [Abstract][Full Text] [Related]
11. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Cody V; Galitsky N; Rak D; Luft JR; Pangborn W; Queener SF Biochemistry; 1999 Apr; 38(14):4303-12. PubMed ID: 10194348 [TBL] [Abstract][Full Text] [Related]
12. Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes. Cody V; Pace J; Makin J; Piraino J; Queener SF; Rosowsky A Biochemistry; 2009 Mar; 48(8):1702-11. PubMed ID: 19196009 [TBL] [Abstract][Full Text] [Related]
13. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Cody V; Luft JR; Pangborn W; Gangjee A; Queener SF Acta Crystallogr D Biol Crystallogr; 2004 Apr; 60(Pt 4):646-55. PubMed ID: 15039552 [TBL] [Abstract][Full Text] [Related]
14. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. Rosowsky A; Forsch RA; Queener SF J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594 [TBL] [Abstract][Full Text] [Related]
15. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Cody V; Luft JR; Pangborn W Acta Crystallogr D Biol Crystallogr; 2005 Feb; 61(Pt 2):147-55. PubMed ID: 15681865 [TBL] [Abstract][Full Text] [Related]
16. Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants. Cody V; Pace J; Queener SF; Adair OO; Gangjee A Antimicrob Agents Chemother; 2013 Jun; 57(6):2669-77. PubMed ID: 23545530 [TBL] [Abstract][Full Text] [Related]
17. The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. Champness JN; Achari A; Ballantine SP; Bryant PK; Delves CJ; Stammers DK Structure; 1994 Oct; 2(10):915-24. PubMed ID: 7866743 [TBL] [Abstract][Full Text] [Related]
18. Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase. Cody V; Luft JR; Pangborn W; Gangjee A Acta Crystallogr D Biol Crystallogr; 2003 Sep; 59(Pt 9):1603-9. PubMed ID: 12925791 [TBL] [Abstract][Full Text] [Related]
19. X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor. Whitlow M; Howard AJ; Stewart D; Hardman KD; Chan JH; Baccanari DP; Tansik RL; Hong JS; Kuyper LF J Med Chem; 2001 Aug; 44(18):2928-32. PubMed ID: 11520201 [TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain. Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]