These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

215 related articles for article (PubMed ID: 18708635)

  • 1. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions.
    Gonzalez-Cabrera PJ; Jo E; Sanna MG; Brown S; Leaf N; Marsolais D; Schaeffer MT; Chapman J; Cameron M; Guerrero M; Roberts E; Rosen H
    Mol Pharmacol; 2008 Nov; 74(5):1308-18. PubMed ID: 18708635
    [TBL] [Abstract][Full Text] [Related]  

  • 2. S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.
    Gonzalez-Cabrera PJ; Cahalan SM; Nguyen N; Sarkisyan G; Leaf NB; Cameron MD; Kago T; Rosen H
    Mol Pharmacol; 2012 Feb; 81(2):166-74. PubMed ID: 22031473
    [TBL] [Abstract][Full Text] [Related]  

  • 3. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
    Jo E; Sanna MG; Gonzalez-Cabrera PJ; Thangada S; Tigyi G; Osborne DA; Hla T; Parrill AL; Rosen H
    Chem Biol; 2005 Jun; 12(6):703-15. PubMed ID: 15975516
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment.
    Cheng Q; Ma S; Lin D; Mei Y; Gong H; Lei L; Chen Y; Zhao Y; Hu B; Wu Y; Yu X; Zhao L; Liu H
    Cell Mol Immunol; 2015 Nov; 12(6):681-91. PubMed ID: 25088224
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel selective allosteric and bitopic ligands for the S1P(3) receptor.
    Jo E; Bhhatarai B; Repetto E; Guerrero M; Riley S; Brown SJ; Kohno Y; Roberts E; Schürer SC; Rosen H
    ACS Chem Biol; 2012 Dec; 7(12):1975-83. PubMed ID: 22971058
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A sphingosine 1-phosphate receptor 2 selective allosteric agonist.
    Satsu H; Schaeffer MT; Guerrero M; Saldana A; Eberhart C; Hodder P; Cayanan C; Schürer S; Bhhatarai B; Roberts E; Rosen H; Brown SJ
    Bioorg Med Chem; 2013 Sep; 21(17):5373-82. PubMed ID: 23849205
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity.
    Scott FL; Clemons B; Brooks J; Brahmachary E; Powell R; Dedman H; Desale HG; Timony GA; Martinborough E; Rosen H; Roberts E; Boehm MF; Peach RJ
    Br J Pharmacol; 2016 Jun; 173(11):1778-92. PubMed ID: 26990079
    [TBL] [Abstract][Full Text] [Related]  

  • 8. FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction.
    Sobel K; Monnier L; Menyhart K; Bolinger M; Studer R; Nayler O; Gatfield J
    Mol Pharmacol; 2015 Jun; 87(6):916-27. PubMed ID: 25762025
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter™ and Ca2+ release functional assays.
    Riddy DM; Stamp C; Sykes DA; Charlton SJ; Dowling MR
    Br J Pharmacol; 2012 Oct; 167(4):868-80. PubMed ID: 22577868
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification and Structure-Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P
    Liu T; Jin J; Chen Y; Xi Q; Hu J; Jia W; Chen X; Li Y; Wang X; Yin D
    Bioorg Chem; 2019 Feb; 82():41-57. PubMed ID: 30268973
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
    Janes K; Little JW; Li C; Bryant L; Chen C; Chen Z; Kamocki K; Doyle T; Snider A; Esposito E; Cuzzocrea S; Bieberich E; Obeid L; Petrache I; Nicol G; Neumann WL; Salvemini D
    J Biol Chem; 2014 Jul; 289(30):21082-97. PubMed ID: 24876379
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.
    Schürer SC; Brown SJ; Gonzalez-Cabrera PJ; Schaeffer MT; Chapman J; Jo E; Chase P; Spicer T; Hodder P; Rosen H
    ACS Chem Biol; 2008 Aug; 3(8):486-98. PubMed ID: 18590333
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.
    Quattropani A; Sauer WH; Crosignani S; Dorbais J; Gerber P; Gonzalez J; Marin D; Muzerelle M; Beltran F; Nichols A; Georgi K; Schneider M; Vitte PA; Eligert V; Novo-Perez L; Hantson J; Nock S; Carboni S; de Souza AL; Arrighi JF; Boschert U; Bombrun A
    ChemMedChem; 2015 Apr; 10(4):688-714. PubMed ID: 25735812
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
    Li C; Li JN; Kays J; Guerrero M; Nicol GD
    J Neuroinflammation; 2015 Apr; 12():70. PubMed ID: 25880547
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.
    Poti F; Costa S; Bergonzini V; Galletti M; Pignatti E; Weber C; Simoni M; Nofer JR
    Vascul Pharmacol; 2012 Aug; 57(1):56-64. PubMed ID: 22459073
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss.
    Blanco R; Martínez-Navarrete G; Valiente-Soriano FJ; Avilés-Trigueros M; Pérez-Rico C; Serrano-Puebla A; Boya P; Fernández E; Vidal-Sanz M; de la Villa P
    Exp Eye Res; 2017 Nov; 164():37-45. PubMed ID: 28827028
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
    Gonzalez-Cabrera PJ; Hla T; Rosen H
    J Biol Chem; 2007 Mar; 282(10):7254-64. PubMed ID: 17218309
    [TBL] [Abstract][Full Text] [Related]  

  • 18. ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
    Yamamoto R; Okada Y; Hirose J; Koshika T; Kawato Y; Maeda M; Saito R; Hattori K; Harada H; Nagasaka Y; Morokata T
    PLoS One; 2014; 9(10):e110819. PubMed ID: 25347187
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5.
    Selkirk JV; Dines KC; Yan YG; Ching N; Dalvie D; Biswas S; Bortolato A; Schkeryantz JM; Lopez C; Ruiz I; Hargreaves R
    J Pharmacol Exp Ther; 2021 Dec; 379(3):386-399. PubMed ID: 34535564
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice.
    Tarrasón G; Aulí M; Mustafa S; Dolgachev V; Domènech MT; Prats N; Domínguez M; López R; Aguilar N; Calbet M; Pont M; Milligan G; Kunkel SL; Godessart N
    Int Immunopharmacol; 2011 Nov; 11(11):1773-9. PubMed ID: 21798372
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.