156 related articles for article (PubMed ID: 18712749)
1. Constructing and analyzing the fitness landscape of an experimental evolutionary process.
Reetz MT; Sanchis J
Chembiochem; 2008 Sep; 9(14):2260-7. PubMed ID: 18712749
[TBL] [Abstract][Full Text] [Related]
2. Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes.
Reetz MT; Carballeira JD
Nat Protoc; 2007; 2(4):891-903. PubMed ID: 17446890
[TBL] [Abstract][Full Text] [Related]
3. Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods.
Reetz MT; Prasad S; Carballeira JD; Gumulya Y; Bocola M
J Am Chem Soc; 2010 Jul; 132(26):9144-52. PubMed ID: 20536132
[TBL] [Abstract][Full Text] [Related]
4. Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis.
Reetz MT; Kahakeaw D; Sanchis J
Mol Biosyst; 2009 Feb; 5(2):115-22. PubMed ID: 19156255
[TBL] [Abstract][Full Text] [Related]
5. Many pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima.
Gumulya Y; Sanchis J; Reetz MT
Chembiochem; 2012 May; 13(7):1060-6. PubMed ID: 22522601
[TBL] [Abstract][Full Text] [Related]
6. Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary pathways.
Gumulya Y; Reetz MT
Chembiochem; 2011 Nov; 12(16):2502-10. PubMed ID: 21913300
[TBL] [Abstract][Full Text] [Related]
7. Addressing the numbers problem in directed evolution.
Reetz MT; Kahakeaw D; Lohmer R
Chembiochem; 2008 Jul; 9(11):1797-804. PubMed ID: 18567049
[TBL] [Abstract][Full Text] [Related]
8. Knowledge-guided laboratory evolution of protein thermolability.
Reetz MT; Soni P; Fernández L
Biotechnol Bioeng; 2009 Apr; 102(6):1712-7. PubMed ID: 19072845
[TBL] [Abstract][Full Text] [Related]
9. Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage.
Reetz MT; Bocola M; Wang LW; Sanchis J; Cronin A; Arand M; Zou J; Archelas A; Bottalla AL; Naworyta A; Mowbray SL
J Am Chem Soc; 2009 Jun; 131(21):7334-43. PubMed ID: 19469578
[TBL] [Abstract][Full Text] [Related]
10. Inverting enantioselectivity of Burkholderia gladioli esterase EstB by directed and designed evolution.
Ivancic M; Valinger G; Gruber K; Schwab H
J Biotechnol; 2007 Mar; 129(1):109-22. PubMed ID: 17147964
[TBL] [Abstract][Full Text] [Related]
11. Surveying a local fitness landscape of a protein with epistatic sites for the study of directed evolution.
Aita T; Hamamatsu N; Nomiya Y; Uchiyama H; Shibanaka Y; Husimi Y
Biopolymers; 2002 Jul; 64(2):95-105. PubMed ID: 11979520
[TBL] [Abstract][Full Text] [Related]
12. Revealing evolutionary pathways by fitness landscape reconstruction.
Kogenaru M; de Vos MG; Tans SJ
Crit Rev Biochem Mol Biol; 2009; 44(4):169-74. PubMed ID: 19552615
[TBL] [Abstract][Full Text] [Related]
13. Mutations in distant residues moderately increase the enantioselectivity of Pseudomonas fluorescens esterase towards methyl 3bromo-2-methylpropanoate and ethyl 3phenylbutyrate.
Horsman GP; Liu AM; Henke E; Bornscheuer UT; Kazlauskas RJ
Chemistry; 2003 May; 9(9):1933-9. PubMed ID: 12740839
[TBL] [Abstract][Full Text] [Related]
14. Exploring the effect of sex on empirical fitness landscapes.
de Visser JA; Park SC; Krug J
Am Nat; 2009 Jul; 174 Suppl 1():S15-30. PubMed ID: 19456267
[TBL] [Abstract][Full Text] [Related]
15. Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution.
Reetz MT; Zheng H
Chembiochem; 2011 Jul; 12(10):1529-35. PubMed ID: 21567703
[TBL] [Abstract][Full Text] [Related]
16. Distributions of enzyme residues yielding mutants with improved substrate specificities from two different directed evolution strategies.
Paramesvaran J; Hibbert EG; Russell AJ; Dalby PA
Protein Eng Des Sel; 2009 Jul; 22(7):401-11. PubMed ID: 19502357
[TBL] [Abstract][Full Text] [Related]
17. Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences.
Moore JC; Jin HM; Kuchner O; Arnold FH
J Mol Biol; 1997 Sep; 272(3):336-47. PubMed ID: 9325094
[TBL] [Abstract][Full Text] [Related]
18. Thermodynamical interpretation of evolutionary dynamics on a fitness landscape in an evolution reactor, II.
Aita T; Morinaga S; Husimi Y
Bull Math Biol; 2005 May; 67(3):613-35. PubMed ID: 15820744
[TBL] [Abstract][Full Text] [Related]
19. Combination of computational prescreening and experimental library construction can accelerate enzyme optimization by directed evolution.
Funke SA; Otte N; Eggert T; Bocola M; Jaeger KE; Thiel W
Protein Eng Des Sel; 2005 Nov; 18(11):509-14. PubMed ID: 16203748
[TBL] [Abstract][Full Text] [Related]
20. Iterative saturation mutagenesis: a powerful approach to engineer proteins by systematically simulating Darwinian evolution.
Acevedo-Rocha CG; Hoebenreich S; Reetz MT
Methods Mol Biol; 2014; 1179():103-28. PubMed ID: 25055773
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
