BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

654 related articles for article (PubMed ID: 18774711)

  • 1. Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
    Melamed JY; Egbertson MS; Varga S; Vacca JP; Moyer G; Gabryelski L; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Hazuda DJ; Leonard Y; Jin L; Ellis JD; Young SD
    Bioorg Med Chem Lett; 2008 Oct; 18(19):5307-10. PubMed ID: 18774711
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
    Zhuang L; Wai JS; Embrey MW; Fisher TE; Egbertson MS; Payne LS; Guare JP; Vacca JP; Hazuda DJ; Felock PJ; Wolfe AL; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Leonard YM; Lynch JJ; Michelson SR; Young SD
    J Med Chem; 2003 Feb; 46(4):453-6. PubMed ID: 12570367
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
    Guare JP; Wai JS; Gomez RP; Anthony NJ; Jolly SM; Cortes AR; Vacca JP; Felock PJ; Stillmock KA; Schleif WA; Moyer G; Gabryelski LJ; Jin L; Chen IW; Hazuda DJ; Young SD
    Bioorg Med Chem Lett; 2006 Jun; 16(11):2900-4. PubMed ID: 16554152
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
    Boros EE; Edwards CE; Foster SA; Fuji M; Fujiwara T; Garvey EP; Golden PL; Hazen RJ; Jeffrey JL; Johns BA; Kawasuji T; Kiyama R; Koble CS; Kurose N; Miller WH; Mote AL; Murai H; Sato A; Thompson JB; Woodward MC; Yoshinaga T
    J Med Chem; 2009 May; 52(9):2754-61. PubMed ID: 19374386
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
    Embrey MW; Wai JS; Funk TW; Homnick CF; Perlow DS; Young SD; Vacca JP; Hazuda DJ; Felock PJ; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Wong BK; Lin JH; Leonard YM; Tsou NN; Zhuang L
    Bioorg Med Chem Lett; 2005 Oct; 15(20):4550-4. PubMed ID: 16102965
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
    Johns BA; Weatherhead JG; Allen SH; Thompson JB; Garvey EP; Foster SA; Jeffrey JL; Miller WH
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1807-10. PubMed ID: 19217284
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
    Verschueren WG; Dierynck I; Amssoms KI; Hu L; Boonants PM; Pille GM; Daeyaert FF; Hertogs K; Surleraux DL; Wigerinck PB
    J Med Chem; 2005 Mar; 48(6):1930-40. PubMed ID: 15771437
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
    Johns BA; Weatherhead JG; Allen SH; Thompson JB; Garvey EP; Foster SA; Jeffrey JL; Miller WH
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1802-6. PubMed ID: 19217781
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A platform for designing HIV integrase inhibitors. Part 1: 2-hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores.
    Kawasuji T; Yoshinaga T; Sato A; Yodo M; Fujiwara T; Kiyama R
    Bioorg Med Chem; 2006 Dec; 14(24):8430-45. PubMed ID: 17010623
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.
    Kawasuji T; Fuji M; Yoshinaga T; Sato A; Fujiwara T; Kiyama R
    Bioorg Med Chem; 2006 Dec; 14(24):8420-9. PubMed ID: 17005407
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
    Rajamaki S; Innitzer A; Falciani C; Tintori C; Christ F; Witvrouw M; Debyser Z; Massa S; Botta M
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3615-8. PubMed ID: 19447621
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.
    Pace P; Spieser SA; Summa V
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3865-9. PubMed ID: 18595690
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A potent and orally active HIV-1 integrase inhibitor.
    Egbertson MS; Moritz HM; Melamed JY; Han W; Perlow DS; Kuo MS; Embrey M; Vacca JP; Zrada MM; Cortes AR; Wallace A; Leonard Y; Hazuda DJ; Miller MD; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Gabryelski LJ; Moyer G; Ellis JD; Jin L; Xu W; Braun MP; Kassahun K; Tsou NN; Young SD
    Bioorg Med Chem Lett; 2007 Mar; 17(5):1392-8. PubMed ID: 17194584
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, antiviral, and anti-HIV-1 integrase activities of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines.
    Brzozowski Z; Saczewski F; Sanchez T; Kuo CL; Gdaniec M; Neamati N
    Bioorg Med Chem; 2004 Jul; 12(13):3663-72. PubMed ID: 15186851
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
    Hazuda DJ; Anthony NJ; Gomez RP; Jolly SM; Wai JS; Zhuang L; Fisher TE; Embrey M; Guare JP; Egbertson MS; Vacca JP; Huff JR; Felock PJ; Witmer MV; Stillmock KA; Danovich R; Grobler J; Miller MD; Espeseth AS; Jin L; Chen IW; Lin JH; Kassahun K; Ellis JD; Wong BK; Xu W; Pearson PG; Schleif WA; Cortese R; Emini E; Summa V; Holloway MK; Young SD
    Proc Natl Acad Sci U S A; 2004 Aug; 101(31):11233-8. PubMed ID: 15277684
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
    Zeng LF; Wang Y; Kazemi R; Xu S; Xu ZL; Sanchez TW; Yang LM; Debnath B; Odde S; Xie H; Zheng YT; Ding J; Neamati N; Long YQ
    J Med Chem; 2012 Nov; 55(22):9492-509. PubMed ID: 23098137
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chemistry and structure-activity relationship of HIV-1 integrase inhibitor integracide B and related natural products.
    Singh SB; Ondeyka JG; Schleif WA; Felock P; Hazuda DJ
    J Nat Prod; 2003 Oct; 66(10):1338-44. PubMed ID: 14575434
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
    Walker MA; Johnson T; Ma Z; Banville J; Remillard R; Kim O; Zhang Y; Staab A; Wong H; Torri A; Samanta H; Lin Z; Deminie C; Terry B; Krystal M; Meanwell N
    Bioorg Med Chem Lett; 2006 Jun; 16(11):2920-4. PubMed ID: 16546383
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.
    Meadows DC; Mathews TB; North TW; Hadd MJ; Kuo CL; Neamati N; Gervay-Hague J
    J Med Chem; 2005 Jul; 48(14):4526-34. PubMed ID: 15999991
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
    Johnson TW; Tanis SP; Butler SL; Dalvie D; Delisle DM; Dress KR; Flahive EJ; Hu Q; Kuehler JE; Kuki A; Liu W; McClellan GA; Peng Q; Plewe MB; Richardson PF; Smith GL; Solowiej J; Tran KT; Wang H; Yu X; Zhang J; Zhu H
    J Med Chem; 2011 May; 54(9):3393-417. PubMed ID: 21446745
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 33.