242 related articles for article (PubMed ID: 18785192)
21. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Lau A; Wang XJ; Zhao F; Villeneuve NF; Wu T; Jiang T; Sun Z; White E; Zhang DD
Mol Cell Biol; 2010 Jul; 30(13):3275-85. PubMed ID: 20421418
[TBL] [Abstract][Full Text] [Related]
22. Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration.
Fan X; Chen P; Tan H; Zeng H; Jiang Y; Wang Y; Wang Y; Hou X; Bi H; Huang M
Drug Metab Dispos; 2014 Sep; 42(9):1532-9. PubMed ID: 25002747
[TBL] [Abstract][Full Text] [Related]
23. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Lee DH; Park JS; Lee YS; Han J; Lee DK; Kwon SW; Han DH; Lee YH; Bae SH
Autophagy; 2020 Nov; 16(11):1949-1973. PubMed ID: 31913745
[TBL] [Abstract][Full Text] [Related]
24. Nrf2 protects against furosemide-induced hepatotoxicity.
Qu Q; Liu J; Zhou HH; Klaassen CD
Toxicology; 2014 Oct; 324():35-42. PubMed ID: 24813929
[TBL] [Abstract][Full Text] [Related]
25. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Yates MS; Tran QT; Dolan PM; Osburn WO; Shin S; McCulloch CC; Silkworth JB; Taguchi K; Yamamoto M; Williams CR; Liby KT; Sporn MB; Sutter TR; Kensler TW
Carcinogenesis; 2009 Jun; 30(6):1024-31. PubMed ID: 19386581
[TBL] [Abstract][Full Text] [Related]
26. Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.
Yin S; Cao W
Mol Cell Biol; 2015 Aug; 35(15):2673-83. PubMed ID: 26012548
[TBL] [Abstract][Full Text] [Related]
27. Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway.
Copple IM; Lister A; Obeng AD; Kitteringham NR; Jenkins RE; Layfield R; Foster BJ; Goldring CE; Park BK
J Biol Chem; 2010 May; 285(22):16782-8. PubMed ID: 20378532
[TBL] [Abstract][Full Text] [Related]
28. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet.
Slocum SL; Skoko JJ; Wakabayashi N; Aja S; Yamamoto M; Kensler TW; Chartoumpekis DV
Arch Biochem Biophys; 2016 Feb; 591():57-65. PubMed ID: 26701603
[TBL] [Abstract][Full Text] [Related]
29. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju A; Copple IM; Bryan HK; Edge GT; Sison RL; Wong MW; Lai ZQ; Lin ZX; Dunn K; Sanderson CM; Alghanem AF; Cross MJ; Ellis EC; Ingelman-Sundberg M; Malik HZ; Kitteringham NR; Goldring CE; Park BK
Free Radic Biol Med; 2015 Jan; 78():202-12. PubMed ID: 25445704
[TBL] [Abstract][Full Text] [Related]
30. KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
Sun Z; Wu T; Zhao F; Lau A; Birch CM; Zhang DD
Mol Cell Biol; 2011 May; 31(9):1800-11. PubMed ID: 21383067
[TBL] [Abstract][Full Text] [Related]
31. Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity.
Reisman SA; Csanaky IL; Yeager RL; Klaassen CD
Toxicol Sci; 2009 May; 109(1):24-30. PubMed ID: 19246623
[TBL] [Abstract][Full Text] [Related]
32. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
Ogura T; Tong KI; Mio K; Maruyama Y; Kurokawa H; Sato C; Yamamoto M
Proc Natl Acad Sci U S A; 2010 Feb; 107(7):2842-7. PubMed ID: 20133743
[TBL] [Abstract][Full Text] [Related]
33. Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.
Williamson TP; Johnson DA; Johnson JA
Neurotoxicology; 2012 Jun; 33(3):272-9. PubMed ID: 22342405
[TBL] [Abstract][Full Text] [Related]
34. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Inami Y; Waguri S; Sakamoto A; Kouno T; Nakada K; Hino O; Watanabe S; Ando J; Iwadate M; Yamamoto M; Lee MS; Tanaka K; Komatsu M
J Cell Biol; 2011 Apr; 193(2):275-84. PubMed ID: 21482715
[TBL] [Abstract][Full Text] [Related]
35. Genetic analysis of cytoprotective functions supported by graded expression of Keap1.
Taguchi K; Maher JM; Suzuki T; Kawatani Y; Motohashi H; Yamamoto M
Mol Cell Biol; 2010 Jun; 30(12):3016-26. PubMed ID: 20404090
[TBL] [Abstract][Full Text] [Related]
36. Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish.
Li L; Kobayashi M; Kaneko H; Nakajima-Takagi Y; Nakayama Y; Yamamoto M
J Biol Chem; 2008 Feb; 283(6):3248-3255. PubMed ID: 18057000
[TBL] [Abstract][Full Text] [Related]
37. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.
Itoh K; Tong KI; Yamamoto M
Free Radic Biol Med; 2004 May; 36(10):1208-13. PubMed ID: 15110385
[TBL] [Abstract][Full Text] [Related]
38. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis.
Kong X; Thimmulappa R; Craciun F; Harvey C; Singh A; Kombairaju P; Reddy SP; Remick D; Biswal S
Am J Respir Crit Care Med; 2011 Oct; 184(8):928-38. PubMed ID: 21799073
[TBL] [Abstract][Full Text] [Related]
39. Subcellular distribution and Nrf2/Keap1-interacting properties of Glutathione S-transferase P in hepatocellular carcinoma.
Bartolini D; Stabile AM; Migni A; Gurrado F; Lioci G; De Franco F; Mandarano M; Svegliati-Baroni G; Di Cristina M; Bellezza G; Rende M; Galli F
Arch Biochem Biophys; 2024 Jul; 757():110043. PubMed ID: 38789086
[TBL] [Abstract][Full Text] [Related]
40. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice.
Yagishita Y; Fukutomi T; Sugawara A; Kawamura H; Takahashi T; Pi J; Uruno A; Yamamoto M
Diabetes; 2014 Feb; 63(2):605-18. PubMed ID: 24186865
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
