213 related articles for article (PubMed ID: 18788755)
1. Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
Madsen KG; Grönberg G; Skonberg C; Jurva U; Hansen SH; Olsen J
Chem Res Toxicol; 2008 Oct; 21(10):2035-41. PubMed ID: 18788755
[TBL] [Abstract][Full Text] [Related]
2. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
He K; Talaat RE; Pool WF; Reily MD; Reed JE; Bridges AJ; Woolf TF
Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
[TBL] [Abstract][Full Text] [Related]
3. Toxic metabolite formation from Troglitazone (TGZ): new insights from a DFT study.
Dixit VA; Bharatam PV
Chem Res Toxicol; 2011 Jul; 24(7):1113-22. PubMed ID: 21657230
[TBL] [Abstract][Full Text] [Related]
4. Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
He K; Talaat RE; Woolf TF
Drug Metab Dispos; 2004 Apr; 32(4):442-6. PubMed ID: 15039298
[TBL] [Abstract][Full Text] [Related]
5. Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium.
Tahara K; Nishikawa T; Hattori Y; Iijima S; Kouno Y; Abe Y
J Pharm Biomed Anal; 2009 Dec; 50(5):1030-6. PubMed ID: 19581066
[TBL] [Abstract][Full Text] [Related]
6. Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
Madsen KG; Olsen J; Skonberg C; Hansen SH; Jurva U
Chem Res Toxicol; 2007 May; 20(5):821-31. PubMed ID: 17447796
[TBL] [Abstract][Full Text] [Related]
7. Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
Alvarez-Sanchez R; Montavon F; Hartung T; Pähler A
Chem Res Toxicol; 2006 Aug; 19(8):1106-16. PubMed ID: 16918252
[TBL] [Abstract][Full Text] [Related]
8. Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
Madsen KG; Skonberg C; Jurva U; Cornett C; Hansen SH; Johansen TN; Olsen J
Chem Res Toxicol; 2008 May; 21(5):1107-19. PubMed ID: 18419141
[TBL] [Abstract][Full Text] [Related]
9. Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review.
Masubuchi Y
Drug Metab Pharmacokinet; 2006 Oct; 21(5):347-56. PubMed ID: 17072088
[TBL] [Abstract][Full Text] [Related]
10. Metabolic activation of pioglitazone identified from rat and human liver microsomes and freshly isolated hepatocytes.
Baughman TM; Graham RA; Wells-Knecht K; Silver IS; Tyler LO; Wells-Knecht M; Zhao Z
Drug Metab Dispos; 2005 Jun; 33(6):733-8. PubMed ID: 15764718
[TBL] [Abstract][Full Text] [Related]
11. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
Reddy VB; Karanam BV; Gruber WL; Wallace MA; Vincent SH; Franklin RB; Baillie TA
Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
[TBL] [Abstract][Full Text] [Related]
12. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.
Saha S; New LS; Ho HK; Chui WK; Chan EC
Toxicol Lett; 2010 Feb; 192(2):141-9. PubMed ID: 19854250
[TBL] [Abstract][Full Text] [Related]
13. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
14. Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
He K; Woolf TF; Kindt EK; Fielder AE; Talaat RE
Biochem Pharmacol; 2001 Jul; 62(2):191-8. PubMed ID: 11389877
[TBL] [Abstract][Full Text] [Related]
15. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Kassahun K; Pearson PG; Tang W; McIntosh I; Leung K; Elmore C; Dean D; Wang R; Doss G; Baillie TA
Chem Res Toxicol; 2001 Jan; 14(1):62-70. PubMed ID: 11170509
[TBL] [Abstract][Full Text] [Related]
16. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
Tettey JN; Maggs JL; Rapeport WG; Pirmohamed M; Park BK
Chem Res Toxicol; 2001 Aug; 14(8):965-74. PubMed ID: 11511170
[TBL] [Abstract][Full Text] [Related]
17. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Liu J; Liu H; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):174-82. PubMed ID: 15720121
[TBL] [Abstract][Full Text] [Related]
18. Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.
Jurva U; Holmén A; Grönberg G; Masimirembwa C; Weidolf L
Chem Res Toxicol; 2008 Apr; 21(4):928-35. PubMed ID: 18361508
[TBL] [Abstract][Full Text] [Related]
19. Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats.
Meechan AJ; Henderson C; Bates CD; Grant MH; Tettey JN
J Pharm Pharmacol; 2006 Oct; 58(10):1359-65. PubMed ID: 17034659
[TBL] [Abstract][Full Text] [Related]
20. Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone.
Okada R; Maeda K; Nishiyama T; Aoyama S; Tozuka Z; Hiratsuka A; Ikeda T; Kusuhara H; Sugiyama Y
Drug Metab Dispos; 2011 Dec; 39(12):2290-7. PubMed ID: 21914835
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
