201 related articles for article (PubMed ID: 18800762)
1. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
K-M Chen C; Hudock MP; Zhang Y; Guo RT; Cao R; No JH; Liang PH; Ko TP; Chang TH; Chang SC; Song Y; Axelson J; Kumar A; Wang AH; Oldfield E
J Med Chem; 2008 Sep; 51(18):5594-607. PubMed ID: 18800762
[TBL] [Abstract][Full Text] [Related]
2. Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.
Gisselberg JE; Herrera Z; Orchard LM; Llinás M; Yeh E
Cell Chem Biol; 2018 Feb; 25(2):185-193.e5. PubMed ID: 29276048
[TBL] [Abstract][Full Text] [Related]
3. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
Zhang Y; Cao R; Yin F; Hudock MP; Guo RT; Krysiak K; Mukherjee S; Gao YG; Robinson H; Song Y; No JH; Bergan K; Leon A; Cass L; Goddard A; Chang TK; Lin FY; Van Beek E; Papapoulos S; Wang AH; Kubo T; Ochi M; Mukkamala D; Oldfield E
J Am Chem Soc; 2009 Apr; 131(14):5153-62. PubMed ID: 19309137
[TBL] [Abstract][Full Text] [Related]
4. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
No JH; de Macedo Dossin F; Zhang Y; Liu YL; Zhu W; Feng X; Yoo JA; Lee E; Wang K; Hui R; Freitas-Junior LH; Oldfield E
Proc Natl Acad Sci U S A; 2012 Mar; 109(11):4058-63. PubMed ID: 22392982
[TBL] [Abstract][Full Text] [Related]
5. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Guo RT; Cao R; Liang PH; Ko TP; Chang TH; Hudock MP; Jeng WY; Chen CK; Zhang Y; Song Y; Kuo CJ; Yin F; Oldfield E; Wang AH
Proc Natl Acad Sci U S A; 2007 Jun; 104(24):10022-7. PubMed ID: 17535895
[TBL] [Abstract][Full Text] [Related]
6. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Cao R; Chen CK; Guo RT; Wang AH; Oldfield E
Proteins; 2008 Nov; 73(2):431-9. PubMed ID: 18442135
[TBL] [Abstract][Full Text] [Related]
7. Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis.
Lisnyansky M; Yariv E; Segal O; Marom M; Loewenstein A; Ben-Tal N; Giladi M; Haitin Y
Mol Pharmacol; 2019 Nov; 96(5):580-588. PubMed ID: 31427399
[TBL] [Abstract][Full Text] [Related]
8. Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Wiemer AJ; Yu JS; Lamb KM; Hohl RJ; Wiemer DF
Bioorg Med Chem; 2008 Jan; 16(1):390-9. PubMed ID: 17905588
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of a series of aromatic bisphosphonates.
Barney RJ; Wasko BM; Dudakovic A; Hohl RJ; Wiemer DF
Bioorg Med Chem; 2010 Oct; 18(20):7212-20. PubMed ID: 20832326
[TBL] [Abstract][Full Text] [Related]
10. Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.
G Ricci C; Liu YL; Zhang Y; Wang Y; Zhu W; Oldfield E; McCammon JA
Biochemistry; 2016 Sep; 55(36):5180-90. PubMed ID: 27564465
[TBL] [Abstract][Full Text] [Related]
11. Impact of α-modifications on the activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
Fairweather AER; Goetz DB; Schroeder CM; Bhuiyan NH; Varney ML; Wiemer DF; Holstein SA
Bioorg Med Chem; 2021 Aug; 44():116307. PubMed ID: 34298413
[TBL] [Abstract][Full Text] [Related]
12. Amides as bioisosteres of triazole-based geranylgeranyl diphosphate synthase inhibitors.
Goetz DB; Varney ML; Wiemer DF; Holstein SA
Bioorg Med Chem; 2020 Aug; 28(16):115604. PubMed ID: 32690260
[TBL] [Abstract][Full Text] [Related]
13. Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.
Wasko BM; Dudakovic A; Hohl RJ
J Pharmacol Exp Ther; 2011 May; 337(2):540-6. PubMed ID: 21335425
[TBL] [Abstract][Full Text] [Related]
14. Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.
Wills VS; Metzger JI; Allen C; Varney ML; Wiemer DF; Holstein SA
Bioorg Med Chem; 2017 Apr; 25(8):2437-2444. PubMed ID: 28302510
[TBL] [Abstract][Full Text] [Related]
15. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation.
Agabiti SS; Li J; Wiemer AJ
Cell Death Dis; 2017 Mar; 8(3):e2678. PubMed ID: 28300835
[TBL] [Abstract][Full Text] [Related]
16. Moiety-linkage map reveals selective nonbisphosphonate inhibitors of human geranylgeranyl diphosphate synthase.
Chen SH; Lin SW; Lin SR; Liang PH; Yang JM
J Chem Inf Model; 2013 Sep; 53(9):2299-311. PubMed ID: 23919676
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Szabo CM; Matsumura Y; Fukura S; Martin MB; Sanders JM; Sengupta S; Cieslak JA; Loftus TC; Lea CR; Lee HJ; Koohang A; Coates RM; Sagami H; Oldfield E
J Med Chem; 2002 May; 45(11):2185-96. PubMed ID: 12014956
[TBL] [Abstract][Full Text] [Related]
18. In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors.
Reilly JE; Zhou X; Tong H; Kuder CH; Wiemer DF; Hohl RJ
Biochem Pharmacol; 2015 Jul; 96(2):83-92. PubMed ID: 25952057
[TBL] [Abstract][Full Text] [Related]
19. Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.
Kabeche S; Aida J; Akther T; Ichikawa T; Ochida A; Pulkoski-Gross MJ; Smith M; Humphries PS; Yeh E
Bioorg Med Chem Lett; 2021 Jun; 41():127978. PubMed ID: 33766764
[TBL] [Abstract][Full Text] [Related]
20. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.
Ling Y; Li ZH; Miranda K; Oldfield E; Moreno SN
J Biol Chem; 2007 Oct; 282(42):30804-16. PubMed ID: 17724033
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]