274 related articles for article (PubMed ID: 18801738)
1. Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.
Stoddart LA; Smith NJ; Jenkins L; Brown AJ; Milligan G
J Biol Chem; 2008 Nov; 283(47):32913-24. PubMed ID: 18801738
[TBL] [Abstract][Full Text] [Related]
2. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.
Hudson BD; Tikhonova IG; Pandey SK; Ulven T; Milligan G
J Biol Chem; 2012 Nov; 287(49):41195-209. PubMed ID: 23066016
[TBL] [Abstract][Full Text] [Related]
3. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.
Milligan G; Stoddart LA; Smith NJ
Br J Pharmacol; 2009 Sep; 158(1):146-53. PubMed ID: 19719777
[TBL] [Abstract][Full Text] [Related]
4. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.
Schmidt J; Smith NJ; Christiansen E; Tikhonova IG; Grundmann M; Hudson BD; Ward RJ; Drewke C; Milligan G; Kostenis E; Ulven T
J Biol Chem; 2011 Mar; 286(12):10628-40. PubMed ID: 21220428
[TBL] [Abstract][Full Text] [Related]
5. Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets.
Ulven T
Front Endocrinol (Lausanne); 2012; 3():111. PubMed ID: 23060857
[TBL] [Abstract][Full Text] [Related]
6. FFA2 and FFA3 in Metabolic Regulation.
Tang C; Offermanns S
Handb Exp Pharmacol; 2017; 236():205-220. PubMed ID: 27757760
[TBL] [Abstract][Full Text] [Related]
7. The Pharmacology and Function of Receptors for Short-Chain Fatty Acids.
Bolognini D; Tobin AB; Milligan G; Moss CE
Mol Pharmacol; 2016 Mar; 89(3):388-98. PubMed ID: 26719580
[TBL] [Abstract][Full Text] [Related]
8. Application of GPCR Structures for Modelling of Free Fatty Acid Receptors.
Tikhonova IG
Handb Exp Pharmacol; 2017; 236():57-77. PubMed ID: 27757764
[TBL] [Abstract][Full Text] [Related]
9. Free fatty acid receptors: structural models and elucidation of ligand binding interactions.
Tikhonova IG; Poerio E
BMC Struct Biol; 2015 Sep; 15():16. PubMed ID: 26346819
[TBL] [Abstract][Full Text] [Related]
10. Signaling of free fatty acid receptors 2 and 3 differs in colonic mucosa following selective agonism or coagonism by luminal propionate.
Tough IR; Forbes S; Cox HM
Neurogastroenterol Motil; 2018 Dec; 30(12):e13454. PubMed ID: 30136343
[TBL] [Abstract][Full Text] [Related]
11. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.
Hudson BD; Due-Hansen ME; Christiansen E; Hansen AM; Mackenzie AE; Murdoch H; Pandey SK; Ward RJ; Marquez R; Tikhonova IG; Ulven T; Milligan G
J Biol Chem; 2013 Jun; 288(24):17296-312. PubMed ID: 23589301
[TBL] [Abstract][Full Text] [Related]
12. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.
Hudson BD; Christiansen E; Tikhonova IG; Grundmann M; Kostenis E; Adams DR; Ulven T; Milligan G
FASEB J; 2012 Dec; 26(12):4951-65. PubMed ID: 22919070
[TBL] [Abstract][Full Text] [Related]
13. Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.
Sergeev E; Hansen AH; Pandey SK; MacKenzie AE; Hudson BD; Ulven T; Milligan G
J Biol Chem; 2016 Jan; 291(1):303-17. PubMed ID: 26518871
[TBL] [Abstract][Full Text] [Related]
14. Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways.
Mikami D; Kobayashi M; Uwada J; Yazawa T; Kamiyama K; Nishimori K; Nishikawa Y; Nishikawa S; Yokoi S; Kimura H; Kimura I; Taniguchi T; Iwano M
Biochim Biophys Acta Mol Cell Biol Lipids; 2020 Jun; 1865(6):158666. PubMed ID: 32061840
[TBL] [Abstract][Full Text] [Related]
15. Short-chain fatty acid sensing in rat duodenum.
Akiba Y; Inoue T; Kaji I; Higashiyama M; Narimatsu K; Iwamoto K; Watanabe M; Guth PH; Engel E; Kuwahara A; Kaunitz JD
J Physiol; 2015 Feb; 593(3):585-99. PubMed ID: 25433076
[TBL] [Abstract][Full Text] [Related]
16. The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A.
Bisenieks E; Vigante B; Petrovska R; Turovska B; Muhamadejev R; Soloduns V; Velena A; Pajuste K; Saso L; Klovins J; Duburs G; Mandrika I
Pharmaceuticals (Basel); 2021 Sep; 14(10):. PubMed ID: 34681211
[TBL] [Abstract][Full Text] [Related]
17. Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.
Lee T; Schwandner R; Swaminath G; Weiszmann J; Cardozo M; Greenberg J; Jaeckel P; Ge H; Wang Y; Jiao X; Liu J; Kayser F; Tian H; Li Y
Mol Pharmacol; 2008 Dec; 74(6):1599-609. PubMed ID: 18818303
[TBL] [Abstract][Full Text] [Related]
18. Ligands at the Free Fatty Acid Receptors 2/3 (GPR43/GPR41).
Milligan G; Bolognini D; Sergeev E
Handb Exp Pharmacol; 2017; 236():17-32. PubMed ID: 27757758
[TBL] [Abstract][Full Text] [Related]
19. Gut feelings in the islets: The role of the gut microbiome and the FFA2 and FFA3 receptors for short chain fatty acids on β-cell function and metabolic regulation.
Teyani R; Moniri NH
Br J Pharmacol; 2023 Dec; 180(24):3113-3129. PubMed ID: 37620991
[TBL] [Abstract][Full Text] [Related]
20. Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum.
Ballout J; Akiba Y; Kaunitz JD; Diener M
Eur J Pharmacol; 2021 Sep; 906():174292. PubMed ID: 34216575
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]