272 related articles for article (PubMed ID: 18801744)
1. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
Steiner H; Winkler E; Haass C
J Biol Chem; 2008 Dec; 283(50):34677-86. PubMed ID: 18801744
[TBL] [Abstract][Full Text] [Related]
2. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
[TBL] [Abstract][Full Text] [Related]
3. Identification of distinct gamma-secretase complexes with different APH-1 variants.
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
J Biol Chem; 2004 Oct; 279(40):41340-5. PubMed ID: 15286082
[TBL] [Abstract][Full Text] [Related]
4. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
5. Toward the structure of presenilin/γ-secretase and presenilin homologs.
Wolfe MS
Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
[TBL] [Abstract][Full Text] [Related]
6. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
[TBL] [Abstract][Full Text] [Related]
7. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
8. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Kim SH; Ikeuchi T; Yu C; Sisodia SS
J Biol Chem; 2003 Sep; 278(36):33992-4002. PubMed ID: 12821663
[TBL] [Abstract][Full Text] [Related]
9. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
Chen AC; Guo LY; Ostaszewski BL; Selkoe DJ; LaVoie MJ
J Biol Chem; 2010 Apr; 285(15):11378-91. PubMed ID: 20145246
[TBL] [Abstract][Full Text] [Related]
10. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
Edbauer D; Kaether C; Steiner H; Haass C
J Biol Chem; 2004 Sep; 279(36):37311-5. PubMed ID: 15210705
[TBL] [Abstract][Full Text] [Related]
11. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
J Biol Chem; 2004 May; 279(22):23255-61. PubMed ID: 15039426
[TBL] [Abstract][Full Text] [Related]
12. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
[TBL] [Abstract][Full Text] [Related]
13. Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.
Chiang PM; Fortna RR; Price DL; Li T; Wong PC
Neurobiol Aging; 2012 Feb; 33(2):277-85. PubMed ID: 20382452
[TBL] [Abstract][Full Text] [Related]
14. From presenilinase to gamma-secretase, cleave to capacitate.
Xia W
Curr Alzheimer Res; 2008 Apr; 5(2):172-8. PubMed ID: 18393802
[TBL] [Abstract][Full Text] [Related]
15. The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity.
Bergman A; Laudon H; Winblad B; Lundkvist J; Näslund J
J Biol Chem; 2004 Oct; 279(44):45564-72. PubMed ID: 15322123
[TBL] [Abstract][Full Text] [Related]
16. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Kim SH; Yin YI; Li YM; Sisodia SS
J Biol Chem; 2004 Nov; 279(47):48615-9. PubMed ID: 15456788
[TBL] [Abstract][Full Text] [Related]
17. Membrane dynamics of γ-secretase with the anterior pharynx-defective 1B subunit.
Dehury B; Kepp KP
J Cell Biochem; 2021 Jan; 122(1):69-85. PubMed ID: 32830360
[TBL] [Abstract][Full Text] [Related]
18. p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.
Dunys J; Kawarai T; Sevalle J; Dolcini V; George-Hyslop PS; Da Costa CA; Checler F
J Biol Chem; 2007 Apr; 282(14):10516-25. PubMed ID: 17276981
[TBL] [Abstract][Full Text] [Related]
19. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
[TBL] [Abstract][Full Text] [Related]
20. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]