BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

257 related articles for article (PubMed ID: 18805691)

  • 1. Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors.
    Xu W; Gray DL; Glase SA; Barta NS
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5550-3. PubMed ID: 18805691
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
    Hudson S; Kiankarimi M; Eccles W; Dwight W; Mostofi YS; Genicot MJ; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4491-4. PubMed ID: 18672364
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
    Wu D; Pontillo J; Ching B; Hudson S; Gao Y; Fleck BA; Gogas K; Wade WS
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4224-7. PubMed ID: 18550369
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template.
    Fish PV; Wakenhut F; Ryckmans T; Stobie A
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4579-83. PubMed ID: 19616432
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors.
    Boot J; Cases M; Clark BP; Findlay J; Gallagher PT; Hayhurst L; Man T; Montalbetti C; Rathmell RE; Rudyk H; Walter MW; Whatton M; Wood V
    Bioorg Med Chem Lett; 2005 Feb; 15(3):699-703. PubMed ID: 15664840
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.
    Pontillo J; Wu D; Ching B; Hudson S; Genicot MJ; Gao Y; Ewing T; Fleck BA; Gogas K; Aparicio A; Wang H; Wen J; Wade WS
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6151-5. PubMed ID: 18954981
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
    Fensome A; Goldberg J; McComas CC; Trybulski EJ; Woodworth RP; Deecher DC; Whiteside GT; Zhang P
    Bioorg Med Chem Lett; 2010 Mar; 20(5):1555-8. PubMed ID: 20153188
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of reboxetine intermediate and carnitine acetyltransferase inhibitor via NBS-induced electrophilic multicomponent reaction.
    Zhou J; Yeung YY
    J Org Chem; 2014 May; 79(10):4644-9. PubMed ID: 24742295
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
    Zhang P; Terefenko EA; McComas CC; Mahaney PE; Vu A; Trybulski E; Koury E; Johnston G; Bray J; Deecher D
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6067-70. PubMed ID: 18951020
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.
    Fish PV; Deur C; Gan X; Greene K; Hoople D; Mackenny M; Para KS; Reeves K; Ryckmans T; Stiff C; Stobie A; Wakenhut F; Whitlock GA
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2562-6. PubMed ID: 18387300
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
    Dounay AB; Barta NS; Campbell BM; Coleman C; Collantes EM; Denny L; Dutta S; Gray DL; Hou D; Iyer R; Maiti SN; Ortwine DF; Probert A; Stratman NC; Subedi R; Whisman T; Xu W; Zoski K
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1114-7. PubMed ID: 20031410
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.
    Kim CY; Mahaney PE; McConnell O; Zhang Y; Manas E; Ho DM; Deecher DC; Trybulski EJ
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5029-32. PubMed ID: 19632110
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Morpholine containing CB2 selective agonists.
    Zindell R; Riether D; Bosanac T; Berry A; Gemkow MJ; Ebneth A; Löbbe S; Raymond EL; Thome D; Shih DT; Thomson D
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1604-9. PubMed ID: 19243942
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
    McComas CC; Vu AT; Mahaney PE; Cohn ST; Fensome A; Marella MA; Nogle L; Trybulski EJ; Ye F; Zhang P; Alfinito P; Bray J; Johnston G; Koury E; Deecher DC
    Bioorg Med Chem Lett; 2008 Sep; 18(18):4929-31. PubMed ID: 18771916
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine.
    Fossa AA; Wisialowski TA; Cremers T; van der Hart M; Tseng E; Deng S; Rollema H; Wang EQ
    Toxicol Appl Pharmacol; 2012 Nov; 264(3):343-50. PubMed ID: 23000177
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Chiral synthesis of (2S,3S)-2-(2-morpholin-2-yl-2-phenylmethoxy)phenol.
    Prabhakaran J; Majo VJ; Mann JJ; Kumar JS
    Chirality; 2004 Mar; 16(3):168-73. PubMed ID: 14770413
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter.
    Cases-Thomas MJ; Masters JJ; Walter MW; Campbell G; Haughton L; Gallagher PT; Dobson DR; Mancuso V; Bonnier B; Giard T; Defrance T; Vanmarsenille M; Ledgard A; White C; Ouwerkerk-Mahadevan S; Brunelle FJ; Dezutter NA; Herbots CA; Lienard JY; Findlay J; Hayhurst L; Boot J; Thompson LK; Hemrick-Luecke S
    Bioorg Med Chem Lett; 2006 Apr; 16(7):2022-5. PubMed ID: 16413778
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitors.
    Zask A; Kaplan J; Verheijen JC; Richard DJ; Curran K; Brooijmans N; Bennett EM; Toral-Barza L; Hollander I; Ayral-Kaloustian S; Yu K
    J Med Chem; 2009 Dec; 52(24):7942-5. PubMed ID: 19916508
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors.
    Kravchenko DV; Kuzovkova YA; Kysil VM; Tkachenko SE; Maliarchouk S; Okun IM; Balakin KV; Ivachtchenko AV
    J Med Chem; 2005 Jun; 48(11):3680-3. PubMed ID: 15916416
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter.
    Jobson NK; Crawford AR; Dewar D; Pimlott SL; Sutherland A
    Bioorg Med Chem Lett; 2009 Sep; 19(17):4996-8. PubMed ID: 19640707
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.