BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

301 related articles for article (PubMed ID: 18815031)

  • 1. Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.
    Anderson M; Andrews DM; Barker AJ; Brassington CA; Breed J; Byth KF; Culshaw JD; Finlay MR; Fisher E; McMiken HH; Green CP; Heaton DW; Nash IA; Newcombe NJ; Oakes SE; Pauptit RA; Roberts A; Stanway JJ; Thomas AP; Tucker JA; Walker M; Weir HM
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5487-92. PubMed ID: 18815031
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode.
    Finlay MR; Acton DG; Andrews DM; Barker AJ; Dennis M; Fisher E; Graham MA; Green CP; Heaton DW; Karoutchi G; Loddick SA; Morgentin R; Roberts A; Tucker JA; Weir HM
    Bioorg Med Chem Lett; 2008 Aug; 18(15):4442-6. PubMed ID: 18617397
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
    Buttar D; Edge M; Emery SC; Fitzek M; Forder C; Griffen A; Hayter B; Hayward CF; Hopcroft PJ; Luke RW; Page K; Stawpert J; Wright A
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4723-6. PubMed ID: 18676144
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure.
    Kawanishi N; Sugimoto T; Shibata J; Nakamura K; Masutani K; Ikuta M; Hirai H
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5122-6. PubMed ID: 16876403
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
    Trujillo JI; Kiefer JR; Huang W; Thorarensen A; Xing L; Caspers NL; Day JE; Mathis KJ; Kretzmer KK; Reitz BA; Weinberg RA; Stegeman RA; Wrightstone A; Christine L; Compton R; Li X
    Bioorg Med Chem Lett; 2009 Feb; 19(3):908-11. PubMed ID: 19097791
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
    Lee J; Choi H; Kim KH; Jeong S; Park JW; Baek CS; Lee SH
    Bioorg Med Chem Lett; 2008 Apr; 18(7):2292-5. PubMed ID: 18353638
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4-(1H-indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors.
    Shafer CM; Lindvall M; Bellamacina C; Gesner TG; Yabannavar A; Jia W; Lin S; Walter A
    Bioorg Med Chem Lett; 2008 Aug; 18(16):4482-5. PubMed ID: 18672368
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38alpha mitogen-activated protein kinase.
    Kim DK; Lim JH; Lee JA; Dewang PM
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4006-10. PubMed ID: 18571921
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors.
    Byth KF; Cooper N; Culshaw JD; Heaton DW; Oakes SE; Minshull CA; Norman RA; Pauptit RA; Tucker JA; Breed J; Pannifer A; Rowsell S; Stanway JJ; Valentine AL; Thomas AP
    Bioorg Med Chem Lett; 2004 May; 14(9):2249-52. PubMed ID: 15081018
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
    Moriarty KJ; Takahashi H; Pullen SS; Khine HH; Sallati RH; Raymond EL; Woska JR; Jeanfavre DD; Roth GP; Winters MP; Qiao L; Ryan D; DesJarlais R; Robinson D; Wilson M; Bobko M; Cook BN; Lo HY; Nemoto PA; Kashem MA; Wolak JP; White A; Magolda RL; Tomczuk B
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5545-9. PubMed ID: 18819799
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors.
    Jones CD; Andrews DM; Barker AJ; Blades K; Byth KF; Finlay MR; Geh C; Green CP; Johannsen M; Walker M; Weir HM
    Bioorg Med Chem Lett; 2008 Dec; 18(24):6486-9. PubMed ID: 18986805
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design of PDK1 inhibitors.
    Poulsen A; Blanchard S; Soh CK; Lee C; Williams M; Wang H; Dymock B
    Bioorg Med Chem Lett; 2012 Jan; 22(1):305-7. PubMed ID: 22119465
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases.
    Hamdouchi C; Zhong B; Mendoza J; Collins E; Jaramillo C; De Diego JE; Robertson D; Spencer CD; Anderson BD; Watkins SA; Zhang F; Brooks HB
    Bioorg Med Chem Lett; 2005 Apr; 15(7):1943-7. PubMed ID: 15780638
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors.
    Guckian KM; Lin EY; Silvian L; Friedman JE; Chin D; Scott DM
    Bioorg Med Chem Lett; 2008 Oct; 18(19):5249-51. PubMed ID: 18778938
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
    Fucini RV; Hanan EJ; Romanowski MJ; Elling RA; Lew W; Barr KJ; Zhu J; Yoburn JC; Liu Y; Fahr BT; Fan J; Lu Y; Pham P; Choong IC; VanderPorten EC; Bui M; Purkey HE; Evanchik MJ; Yang W
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5648-52. PubMed ID: 18793847
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
    Emmitte KA; Wilson BJ; Baum EW; Emerson HK; Kuntz KW; Nailor KE; Salovich JM; Smith SC; Cheung M; Gerding RM; Stevens KL; Uehling DE; Mook RA; Moorthy GS; Dickerson SH; Hassell AM; Leesnitzer MA; Shewchuk LM; Groy A; Rowand JL; Anderson K; Atkins CL; Yang J; Sabbatini P; Kumar R
    Bioorg Med Chem Lett; 2009 Feb; 19(3):1004-8. PubMed ID: 19101143
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.
    Jaramillo C; de Diego JE; Hamdouchi C; Collins E; Keyser H; Sánchez-Martínez C; del Prado M; Norman B; Brooks HB; Watkins SA; Spencer CD; Dempsey JA; Anderson BD; Campbell RM; Leggett T; Patel B; Schultz RM; Espinosa J; Vieth M; Zhang F; Timm DE
    Bioorg Med Chem Lett; 2004 Dec; 14(24):6095-9. PubMed ID: 15546737
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of sulfoximine based inhibitors for HIV-1 protease.
    Raza A; Sham YY; Vince R
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5406-10. PubMed ID: 18829317
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fused thiophene derivatives as MEK inhibitors.
    Laing VE; Brookings DC; Carbery RJ; Simorte JG; Hutchings MC; Langham BJ; Lowe MA; Allen RA; Fetterman JR; Turner J; Meier C; Kennedy J; Merriman M
    Bioorg Med Chem Lett; 2012 Jan; 22(1):472-5. PubMed ID: 22119475
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.
    Liang GB; Qian X; Feng D; Fisher M; Brown CM; Gurnett A; Leavitt PS; Liberator PA; Misura AS; Tamas T; Schmatz DM; Wyvratt M; Biftu T
    Bioorg Med Chem Lett; 2007 Jul; 17(13):3558-61. PubMed ID: 17475489
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.