BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

362 related articles for article (PubMed ID: 18816075)

  • 1. Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
    Damsten MC; de Vlieger JS; Niessen WM; Irth H; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2008 Nov; 21(11):2181-7. PubMed ID: 18816075
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
    Yan Z; Zhong HM; Maher N; Torres R; Leo GC; Caldwell GW; Huebert N
    Drug Metab Dispos; 2005 Dec; 33(12):1867-76. PubMed ID: 16174805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [TBL] [Abstract][Full Text] [Related]  

  • 5. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bioactivation of flutamide metabolites by human liver microsomes.
    Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
    Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry.
    Bu HZ; Zhao P; Dalvie DK; Pool WF
    Rapid Commun Mass Spectrom; 2007; 21(20):3317-22. PubMed ID: 17879390
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP; Ma J; Teffera Y; Waldon DJ
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.
    Wen B; Zhou M
    Chem Biol Interact; 2009 Oct; 181(2):220-6. PubMed ID: 19482014
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
    Wen B; Ma L; Zhu M
    Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q; Zhu M
    Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
    Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
    Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.
    Wen B; Moore DJ
    Drug Metab Dispos; 2011 Sep; 39(9):1511-21. PubMed ID: 21628497
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
    Iverson SL; Shen L; Anlar N; Bolton JL
    Chem Res Toxicol; 1996 Mar; 9(2):492-9. PubMed ID: 8839054
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.
    Zheng J; Ma L; Xin B; Olah T; Humphreys WG; Zhu M
    Chem Res Toxicol; 2007 May; 20(5):757-66. PubMed ID: 17402749
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
    Dragovic S; Boerma JS; van Bergen L; Vermeulen NP; Commandeur JN
    Chem Res Toxicol; 2010 Sep; 23(9):1467-76. PubMed ID: 20849150
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.
    Ding X; Spink DC; Bhama JK; Sheng JJ; Vaz AD; Coon MJ
    Mol Pharmacol; 1996 Jun; 49(6):1113-21. PubMed ID: 8649351
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.