BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

172 related articles for article (PubMed ID: 18825778)

  • 1. NMR-derived folate-bound structure of dihydrofolate reductase 1 from the halophile Haloferax volcanii.
    Boroujerdi AF; Young JK
    Biopolymers; 2009 Feb; 91(2):140-4. PubMed ID: 18825778
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
    Cody V; Galitsky N; Rak D; Luft JR; Pangborn W; Queener SF
    Biochemistry; 1999 Apr; 38(14):4303-12. PubMed ID: 10194348
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.
    Lee H; Reyes VM; Kraut J
    Biochemistry; 1996 Jun; 35(22):7012-20. PubMed ID: 8679526
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii.
    Pieper U; Kapadia G; Mevarech M; Herzberg O
    Structure; 1998 Jan; 6(1):75-88. PubMed ID: 9493269
    [TBL] [Abstract][Full Text] [Related]  

  • 5. NMR assignments of the binary hvDHFR1:folate complex.
    Boroujerdi AF; Binbuga B; Young JK
    Biomol NMR Assign; 2007 Jul; 1(1):139-41. PubMed ID: 19636849
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure in an extreme environment: NMR at high salt.
    Binbuga B; Boroujerdi AF; Young JK
    Protein Sci; 2007 Aug; 16(8):1783-7. PubMed ID: 17656587
    [TBL] [Abstract][Full Text] [Related]  

  • 7. NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
    Johnson JM; Meiering EM; Wright JE; Pardo J; Rosowsky A; Wagner G
    Biochemistry; 1997 Apr; 36(15):4399-411. PubMed ID: 9109647
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An alternative pathway for reduced folate biosynthesis in bacteria and halophilic archaea.
    Levin I; Giladi M; Altman-Price N; Ortenberg R; Mevarech M
    Mol Microbiol; 2004 Dec; 54(5):1307-18. PubMed ID: 15554970
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Determination of the conformation of trimethoprim in the binding pocket of bovine dihydrofolate reductase from a STD-NMR intensity-restrained CORCEMA-ST optimization.
    Jayalakshmi V; Krishna NR
    J Am Chem Soc; 2005 Oct; 127(40):14080-4. PubMed ID: 16201830
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 13C and 15N nuclear magnetic resonance evidence that the active site carboxyl group of dihydrofolate reductase is not involved in the relay of a proton to substrate.
    Blakley RL; Appleman JR; Freisheim JH; Jablonsky MJ
    Arch Biochem Biophys; 1993 Nov; 306(2):501-9. PubMed ID: 8105754
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues.
    Kim HS; Damo SM; Lee SY; Wemmer D; Klinman JP
    Biochemistry; 2005 Aug; 44(34):11428-39. PubMed ID: 16114879
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region.
    Summerfield RL; Daigle DM; Mayer S; Mallik D; Hughes DW; Jackson SG; Sulek M; Organ MG; Brown ED; Junop MS
    J Med Chem; 2006 Nov; 49(24):6977-86. PubMed ID: 17125251
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective injection of magnetization by slow chemical exchange in NMR.
    Boulat B; Epstein DM; Rance M
    J Magn Reson; 1999 Jun; 138(2):268-76. PubMed ID: 10341130
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Incorporating dynamics in E. coli dihydrofolate reductase enhances structure-based drug discovery.
    Lerner MG; Bowman AL; Carlson HA
    J Chem Inf Model; 2007; 47(6):2358-65. PubMed ID: 17877338
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
    Jackson M; Chopra S; Smiley RD; Maynord PO; Rosowsky A; London RE; Levy L; Kalman TI; Howell EE
    Biochemistry; 2005 Sep; 44(37):12420-33. PubMed ID: 16156655
    [TBL] [Abstract][Full Text] [Related]  

  • 17. How dihydrofolate reductase facilitates protonation of dihydrofolate.
    Rod TH; Brooks CL
    J Am Chem Soc; 2003 Jul; 125(29):8718-9. PubMed ID: 12862454
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The extremely halophilic archaeon Haloferax volcanii has two very different dihydrofolate reductases.
    Ortenberg R; Rozenblatt-Rosen O; Mevarech M
    Mol Microbiol; 2000 Mar; 35(6):1493-505. PubMed ID: 10760149
    [TBL] [Abstract][Full Text] [Related]  

  • 19. High pressure NMR reveals active-site hinge motion of folate-bound Escherichia coli dihydrofolate reductase.
    Kitahara R; Sareth S; Yamada H; Ohmae E; Gekko K; Akasaka K
    Biochemistry; 2000 Oct; 39(42):12789-95. PubMed ID: 11041843
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 13C NMR studies of complexes of Escherichia coli dihydrofolate reductase formed with methotrexate and with folic acid.
    Cheung HT; Birdsall B; Feeney J
    FEBS Lett; 1992 Nov; 312(2-3):147-51. PubMed ID: 1426244
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.