BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

308 related articles for article (PubMed ID: 18839173)

  • 1. Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor.
    Harmsen S; Meijerman I; Beijnen JH; Schellens JH
    Cancer Chemother Pharmacol; 2009 Jun; 64(1):35-43. PubMed ID: 18839173
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes.
    Nallani SC; Goodwin B; Buckley AR; Buckley DJ; Desai PB
    Cancer Chemother Pharmacol; 2004 Sep; 54(3):219-29. PubMed ID: 15175893
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
    Kim S; Dinchuk JE; Anthony MN; Orcutt T; Zoeckler ME; Sauer MB; Mosure KW; Vuppugalla R; Grace JE; Simmermacher J; Dulac HA; Pizzano J; Sinz M
    Drug Metab Dispos; 2010 Jan; 38(1):16-24. PubMed ID: 19833845
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
    Moscovitz JE; Lin Z; Johnson N; Tu M; Goosen TC; Weng Y; Kalgutkar AS
    Xenobiotica; 2018 Jul; 48(7):647-655. PubMed ID: 28685622
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
    Yu C; Ye S; Sun H; Liu Y; Gao L; Shen C; Chen S; Zeng S
    Chem Biol Interact; 2009 Jan; 177(1):58-64. PubMed ID: 18805405
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.
    Cooper BW; Cho TM; Thompson PM; Wallace AD
    Toxicol Sci; 2008 Jun; 103(2):268-77. PubMed ID: 18332045
    [TBL] [Abstract][Full Text] [Related]  

  • 8. PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide.
    Zimmermann C; van Waterschoot RA; Harmsen S; Maier A; Gutmann H; Schinkel AH
    Eur J Pharm Sci; 2009 Mar; 36(4-5):565-71. PubMed ID: 19138736
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.
    Doricakova A; Theile D; Weiss J; Vrzal R
    Naunyn Schmiedebergs Arch Pharmacol; 2017 Jan; 390(1):49-59. PubMed ID: 27678410
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
    Luo G; Cunningham M; Kim S; Burn T; Lin J; Sinz M; Hamilton G; Rizzo C; Jolley S; Gilbert D; Downey A; Mudra D; Graham R; Carroll K; Xie J; Madan A; Parkinson A; Christ D; Selling B; LeCluyse E; Gan LS
    Drug Metab Dispos; 2002 Jul; 30(7):795-804. PubMed ID: 12065438
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.
    Taneja G; Chu C; Maturu P; Moorthy B; Ghose R
    Drug Metab Dispos; 2018 Apr; 46(4):397-404. PubMed ID: 29440179
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.
    Vrzal R; Kubesova K; Pavek P; Dvorak Z
    Toxicol Lett; 2010 Mar; 193(2):183-8. PubMed ID: 20080160
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
    Gupta A; Mugundu GM; Desai PB; Thummel KE; Unadkat JD
    Drug Metab Dispos; 2008 Jun; 36(6):1172-80. PubMed ID: 18332086
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.
    Niemira M; Dastych J; Mazerska Z
    Biochem Pharmacol; 2013 Jul; 86(2):231-41. PubMed ID: 23688499
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of panaxytriol on cytochrome P450 3A4 via the pregnane X receptor regulatory pathway.
    Wu J; Yao N; Hu Q; Liu M; Zhang H; Xiong Y; Hu J; Xia C
    Phytother Res; 2019 Apr; 33(4):968-975. PubMed ID: 30653754
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.
    Ghose R; Mallick P; Taneja G; Chu C; Moorthy B
    Methods Mol Biol; 2016; 1395():55-68. PubMed ID: 26910068
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.
    Wang YM; Lin W; Chai SC; Wu J; Ong SS; Schuetz EG; Chen T
    Toxicol Appl Pharmacol; 2013 Oct; 272(1):96-107. PubMed ID: 23707768
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
    Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.
    Rasmussen MK; Daujat-Chavanieu M; Gerbal-Chaloin S
    Toxicol Lett; 2017 Aug; 277():1-8. PubMed ID: 28571685
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.