191 related articles for article (PubMed ID: 18840543)
1. Correct assessment of new compounds using in vivo screening models can reduce false positives.
Bueters TJ; Hoogstraate J; Visser SA
Drug Discov Today; 2009 Jan; 14(1-2):89-94. PubMed ID: 18840543
[TBL] [Abstract][Full Text] [Related]
2. Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward.
Reinhart GA; Fryer RM; Osinski MA; Polakowski JS; Cox BF; Gintant GA
Curr Opin Chem Biol; 2005 Aug; 9(4):392-9. PubMed ID: 15950522
[TBL] [Abstract][Full Text] [Related]
3. Challenges in the search for drugs to treat central nervous system disorders.
Enna SJ; Williams M
J Pharmacol Exp Ther; 2009 May; 329(2):404-11. PubMed ID: 19182069
[TBL] [Abstract][Full Text] [Related]
4. Snapshot PK: a rapid rodent in vivo preclinical screening approach.
Liu B; Chang J; Gordon WP; Isbell J; Zhou Y; Tuntland T
Drug Discov Today; 2008 Apr; 13(7-8):360-7. PubMed ID: 18405850
[TBL] [Abstract][Full Text] [Related]
5. Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration.
Brunner D; Balcı F; Ludvig EA
Behav Processes; 2012 Feb; 89(2):187-95. PubMed ID: 22155361
[TBL] [Abstract][Full Text] [Related]
6. Invertebrate animal models of diseases as screening tools in drug discovery.
Ségalat L
ACS Chem Biol; 2007 Apr; 2(4):231-6. PubMed ID: 17455900
[TBL] [Abstract][Full Text] [Related]
7. The importance of target validation in drug discovery and development.
Lowe JA; Jones P; Wilson DM
Curr Opin Drug Discov Devel; 2009 Sep; 12(5):581-4. PubMed ID: 19736617
[No Abstract] [Full Text] [Related]
8. [Strategy of molecular drug design: hits, leads and drug candidates].
Guo ZR
Yao Xue Xue Bao; 2008 Sep; 43(9):898-904. PubMed ID: 19048779
[TBL] [Abstract][Full Text] [Related]
9. Molecular imaging strategies for drug discovery and development.
Gross S; Piwnica-Worms D
Curr Opin Chem Biol; 2006 Aug; 10(4):334-42. PubMed ID: 16822702
[TBL] [Abstract][Full Text] [Related]
10. Does human pharmacokinetic prediction add significant value to compound selection in drug discovery research?
Beaumont K; Smith DA
Curr Opin Drug Discov Devel; 2009 Jan; 12(1):61-71. PubMed ID: 19152214
[TBL] [Abstract][Full Text] [Related]
11. A role for fMRI in optimizing CNS drug development.
Borsook D; Becerra L; Hargreaves R
Nat Rev Drug Discov; 2006 May; 5(5):411-24. PubMed ID: 16604100
[TBL] [Abstract][Full Text] [Related]
12. [Problems in preclinical pharmacology when deciding on suitable animal species and animal tests models].
Hoefke W
Arzneimittelforschung; 1977 Feb; 27(2A):223-8. PubMed ID: 577167
[TBL] [Abstract][Full Text] [Related]
13. In vivo pharmacological disease models for psoriasis and atopic dermatitis in drug discovery.
Petersen TK
Basic Clin Pharmacol Toxicol; 2006 Aug; 99(2):104-15. PubMed ID: 16918710
[TBL] [Abstract][Full Text] [Related]
14. Fast mouse PK (Fast PK): a rapid screening method to increase pharmacokinetic throughput in pre-clinical drug discovery.
Reddy J; Madishetti S; Vachaspati PR
Eur J Pharm Sci; 2012 Sep; 47(2):444-50. PubMed ID: 22789493
[TBL] [Abstract][Full Text] [Related]
15. Observations on screening-based research and some concerning trends in the literature.
Baell JB
Future Med Chem; 2010 Oct; 2(10):1529-46. PubMed ID: 21426147
[TBL] [Abstract][Full Text] [Related]
16. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
Dalvie D; Obach RS; Kang P; Prakash C; Loi CM; Hurst S; Nedderman A; Goulet L; Smith E; Bu HZ; Smith DA
Chem Res Toxicol; 2009 Feb; 22(2):357-68. PubMed ID: 19146377
[TBL] [Abstract][Full Text] [Related]
17. Preclinical formulations for discovery and toxicology: physicochemical challenges.
Neervannan S
Expert Opin Drug Metab Toxicol; 2006 Oct; 2(5):715-31. PubMed ID: 17014391
[TBL] [Abstract][Full Text] [Related]
18. How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach).
Bakker A; Caricasole A; Gaviraghi G; Pollio G; Robertson G; Terstappen GC; Salerno M; Tunici P
ChemMedChem; 2009 Jun; 4(6):923-33. PubMed ID: 19434656
[TBL] [Abstract][Full Text] [Related]
19. Assessing brain free fraction in early drug discovery.
Read KD; Braggio S
Expert Opin Drug Metab Toxicol; 2010 Mar; 6(3):337-44. PubMed ID: 20102287
[TBL] [Abstract][Full Text] [Related]
20. Translational research in central nervous system drug discovery.
Hurko O; Ryan JL
NeuroRx; 2005 Oct; 2(4):671-82. PubMed ID: 16489374
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]