BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

322 related articles for article (PubMed ID: 18840606)

  • 1. WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.
    Song JJ; Kingston RE
    J Biol Chem; 2008 Dec; 283(50):35258-64. PubMed ID: 18840606
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
    Patel A; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32158-61. PubMed ID: 18829459
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
    Senisterra G; Wu H; Allali-Hassani A; Wasney GA; Barsyte-Lovejoy D; Dombrovski L; Dong A; Nguyen KT; Smil D; Bolshan Y; Hajian T; He H; Seitova A; Chau I; Li F; Poda G; Couture JF; Brown PJ; Al-Awar R; Schapira M; Arrowsmith CH; Vedadi M
    Biochem J; 2013 Jan; 449(1):151-9. PubMed ID: 22989411
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
    Patel A; Vought VE; Swatkoski S; Viggiano S; Howard B; Dharmarajan V; Monteith KE; Kupakuwana G; Namitz KE; Shinsky SA; Cotter RJ; Cosgrove MS
    J Biol Chem; 2014 Jan; 289(2):868-84. PubMed ID: 24235145
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
    Ruthenburg AJ; Wang W; Graybosch DM; Li H; Allis CD; Patel DJ; Verdine GL
    Nat Struct Mol Biol; 2006 Aug; 13(8):704-12. PubMed ID: 16829959
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis for molecular recognition and presentation of histone H3 by WDR5.
    Schuetz A; Allali-Hassani A; Martín F; Loppnau P; Vedadi M; Bochkarev A; Plotnikov AN; Arrowsmith CH; Min J
    EMBO J; 2006 Sep; 25(18):4245-52. PubMed ID: 16946699
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2011 Feb; 286(5):3359-69. PubMed ID: 21106533
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
    Alicea-Velázquez NL; Shinsky SA; Loh DM; Lee JH; Skalnik DG; Cosgrove MS
    J Biol Chem; 2016 Oct; 291(43):22357-22372. PubMed ID: 27563068
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.
    Patel A; Vought VE; Dharmarajan V; Cosgrove MS
    J Biol Chem; 2008 Nov; 283(47):32162-75. PubMed ID: 18829457
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.
    Kim JY; Banerjee T; Vinckevicius A; Luo Q; Parker JB; Baker MR; Radhakrishnan I; Wei JJ; Barish GD; Chakravarti D
    Mol Cell; 2014 May; 54(4):613-25. PubMed ID: 24793694
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular recognition of histone H3 by the WD40 protein WDR5.
    Couture JF; Collazo E; Trievel RC
    Nat Struct Mol Biol; 2006 Aug; 13(8):698-703. PubMed ID: 16829960
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis of nucleosome recognition and modification by MLL methyltransferases.
    Xue H; Yao T; Cao M; Zhu G; Li Y; Yuan G; Chen Y; Lei M; Huang J
    Nature; 2019 Sep; 573(7774):445-449. PubMed ID: 31485071
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
    Grebien F; Vedadi M; Getlik M; Giambruno R; Grover A; Avellino R; Skucha A; Vittori S; Kuznetsova E; Smil D; Barsyte-Lovejoy D; Li F; Poda G; Schapira M; Wu H; Dong A; Senisterra G; Stukalov A; Huber KVM; Schönegger A; Marcellus R; Bilban M; Bock C; Brown PJ; Zuber J; Bennett KL; Al-Awar R; Delwel R; Nerlov C; Arrowsmith CH; Superti-Furga G
    Nat Chem Biol; 2015 Aug; 11(8):571-578. PubMed ID: 26167872
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
    Zhu L; Li Q; Wong SH; Huang M; Klein BJ; Shen J; Ikenouye L; Onishi M; Schneidawind D; Buechele C; Hansen L; Duque-Afonso J; Zhu F; Martin GM; Gozani O; Majeti R; Kutateladze TG; Cleary ML
    Cancer Discov; 2016 Jul; 6(7):770-83. PubMed ID: 27154821
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.
    Chen WL; Li DD; Chen X; Wang YZ; Xu JJ; Jiang ZY; You QD; Guo XK
    Eur J Med Chem; 2020 Feb; 188():112027. PubMed ID: 31923859
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5.
    Han Z; Guo L; Wang H; Shen Y; Deng XW; Chai J
    Mol Cell; 2006 Apr; 22(1):137-44. PubMed ID: 16600877
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
    Dharmarajan V; Lee JH; Patel A; Skalnik DG; Cosgrove MS
    J Biol Chem; 2012 Aug; 287(33):27275-89. PubMed ID: 22665483
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.
    Paggetti J; Largeot A; Aucagne R; Jacquel A; Lagrange B; Yang XJ; Solary E; Bastie JN; Delva L
    Oncogene; 2010 Sep; 29(36):5019-31. PubMed ID: 20581860
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks.
    Southall SM; Wong PS; Odho Z; Roe SM; Wilson JR
    Mol Cell; 2009 Jan; 33(2):181-91. PubMed ID: 19187761
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
    Karatas H; Li Y; Liu L; Ji J; Lee S; Chen Y; Yang J; Huang L; Bernard D; Xu J; Townsend EC; Cao F; Ran X; Li X; Wen B; Sun D; Stuckey JA; Lei M; Dou Y; Wang S
    J Med Chem; 2017 Jun; 60(12):4818-4839. PubMed ID: 28603984
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.