414 related articles for article (PubMed ID: 18841517)
1. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
Tang W; Stearns RA; Wang RW; Miller RR; Chen Q; Ngui J; Bakshi RK; Nargund RP; Dean DC; Baillie TA
Xenobiotica; 2008 Nov; 38(11):1437-51. PubMed ID: 18841517
[TBL] [Abstract][Full Text] [Related]
2. In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
Sahali-Sahly Y; Balani SK; Lin JH; Baillie TA
Chem Res Toxicol; 1996 Sep; 9(6):1007-12. PubMed ID: 8870989
[TBL] [Abstract][Full Text] [Related]
3. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms.
Shayeganpour A; El-Kadi AO; Brocks DR
Drug Metab Dispos; 2006 Jan; 34(1):43-50. PubMed ID: 16204463
[TBL] [Abstract][Full Text] [Related]
4. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
Prakash C; Wang W; O'Connell T; Johnson KA
Drug Metab Dispos; 2008 Oct; 36(10):2093-103. PubMed ID: 18653741
[TBL] [Abstract][Full Text] [Related]
5. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
[TBL] [Abstract][Full Text] [Related]
6. Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist.
Lu C; Balani SK; Qian MG; Prakash SR; Ducray PS; von Moltke LL
J Pharmacol Exp Ther; 2010 Feb; 332(2):562-8. PubMed ID: 19889796
[TBL] [Abstract][Full Text] [Related]
7. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
8. A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors.
Li P; Lu C; Balani SK; Gan LS
Drug Metab Dispos; 2011 Jun; 39(6):1054-7. PubMed ID: 21393461
[TBL] [Abstract][Full Text] [Related]
9. Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design.
Perloff ES; Mason AK; Dehal SS; Blanchard AP; Morgan L; Ho T; Dandeneau A; Crocker RM; Chandler CM; Boily N; Crespi CL; Stresser DM
Xenobiotica; 2009 Feb; 39(2):99-112. PubMed ID: 19255936
[TBL] [Abstract][Full Text] [Related]
10. The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.
Obach RS; Walsky RL; Venkatakrishnan K; Gaman EA; Houston JB; Tremaine LM
J Pharmacol Exp Ther; 2006 Jan; 316(1):336-48. PubMed ID: 16192315
[TBL] [Abstract][Full Text] [Related]
11. Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine.
Wang Y; Wang S; Liu Y; Yan L; Dou G; Gao Y
J Chromatogr B Analyt Technol Biomed Life Sci; 2006 Dec; 844(2):292-300. PubMed ID: 16949890
[TBL] [Abstract][Full Text] [Related]
12. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
Grillo MP; Ma J; Teffera Y; Waldon DJ
Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
[TBL] [Abstract][Full Text] [Related]
13. Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats.
Kanazu T; Sato N; Kadono K; Touchi A; Takeda Y; Yamaguchi Y; Baba T
Biopharm Drug Dispos; 2012 May; 33(4):195-206. PubMed ID: 22447511
[TBL] [Abstract][Full Text] [Related]
14. Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A.
Zhao P; Lee CA; Kunze KL
Drug Metab Dispos; 2007 May; 35(5):704-12. PubMed ID: 17293381
[TBL] [Abstract][Full Text] [Related]
15. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
16. Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Chen Q; Ngui JS; Doss GA; Wang RW; Cai X; DiNinno FP; Blizzard TA; Hammond ML; Stearns RA; Evans DC; Baillie TA; Tang W
Chem Res Toxicol; 2002 Jul; 15(7):907-14. PubMed ID: 12119000
[TBL] [Abstract][Full Text] [Related]
17. Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.
Tang C; Chiba M; Nishime J; Hochman JH; Chen I; Williams TM; Lin JH
Drug Metab Dispos; 2000 Jun; 28(6):680-6. PubMed ID: 10820141
[TBL] [Abstract][Full Text] [Related]
18. Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.
Fitzpatrick JL; Ripp SL; Smith NB; Pierce WM; Prough RA
Arch Biochem Biophys; 2001 May; 389(2):278-87. PubMed ID: 11339818
[TBL] [Abstract][Full Text] [Related]
19. Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.
Sun H; Yost GS
Chem Res Toxicol; 2008 Feb; 21(2):374-85. PubMed ID: 18095656
[TBL] [Abstract][Full Text] [Related]
20. Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.
O'Donnell JP; Dalvie DK; Kalgutkar AS; Obach RS
Drug Metab Dispos; 2003 Nov; 31(11):1369-77. PubMed ID: 14570769
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]