485 related articles for article (PubMed ID: 18842420)
1. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Lindsley SR; Moore KP; Rajapakse HA; Selnick HG; Young MB; Zhu H; Munshi S; Kuo L; McGaughey GB; Colussi D; Crouthamel MC; Lai MT; Pietrak B; Price EA; Sankaranarayanan S; Simon AJ; Seabrook GR; Hazuda DJ; Pudvah NT; Hochman JH; Graham SL; Vacca JP; Nantermet PG
Bioorg Med Chem Lett; 2007 Jul; 17(14):4057-61. PubMed ID: 17482814
[TBL] [Abstract][Full Text] [Related]
3. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
Iserloh U; Wu Y; Cumming JN; Pan J; Wang LY; Stamford AW; Kennedy ME; Kuvelkar R; Chen X; Parker EM; Strickland C; Voigt J
Bioorg Med Chem Lett; 2008 Jan; 18(1):414-7. PubMed ID: 18023580
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic.
Wångsell F; Russo F; Sävmarker J; Rosenquist A; Samuelsson B; Larhed M
Bioorg Med Chem Lett; 2009 Aug; 19(16):4711-4. PubMed ID: 19576765
[TBL] [Abstract][Full Text] [Related]
5. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of potent and selective BACE-1 inhibitors.
Björklund C; Oscarson S; Benkestock K; Borkakoti N; Jansson K; Lindberg J; Vrang L; Hallberg A; Rosenquist A; Samuelsson B
J Med Chem; 2010 Feb; 53(4):1458-64. PubMed ID: 20128595
[TBL] [Abstract][Full Text] [Related]
7. Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.
Barrow JC; Rittle KE; Ngo PL; Selnick HG; Graham SL; Pitzenberger SM; McGaughey GB; Colussi D; Lai MT; Huang Q; Tugusheva K; Espeseth AS; Simon AJ; Munshi SK; Vacca JP
ChemMedChem; 2007 Jul; 2(7):995-9. PubMed ID: 17458843
[No Abstract] [Full Text] [Related]
8. Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Sealy JM; Truong AP; Tso L; Probst GD; Aquino J; Hom RK; Jagodzinska BM; Dressen D; Wone DW; Brogley L; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Dappen MS; Toth G; Pan H; Ruslim L; Miller J; Bova MP; Sinha S; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2009 Nov; 19(22):6386-91. PubMed ID: 19811916
[TBL] [Abstract][Full Text] [Related]
9. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core.
Björklund C; Adolfsson H; Jansson K; Lindberg J; Vrang L; Hallberg A; Rosenquist S; Samuelsson B
Bioorg Med Chem; 2010 Feb; 18(4):1711-23. PubMed ID: 20122837
[TBL] [Abstract][Full Text] [Related]
10. Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives.
Park H; Min K; Kwak HS; Koo KD; Lim D; Seo SW; Choi JU; Platt B; Choi DY
Bioorg Med Chem Lett; 2008 May; 18(9):2900-4. PubMed ID: 18434152
[TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903
[TBL] [Abstract][Full Text] [Related]
12. Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Cumming J; Babu S; Huang Y; Carrol C; Chen X; Favreau L; Greenlee W; Guo T; Kennedy M; Kuvelkar R; Le T; Li G; McHugh N; Orth P; Ozgur L; Parker E; Saionz K; Stamford A; Strickland C; Tadesse D; Voigt J; Zhang L; Zhang Q
Bioorg Med Chem Lett; 2010 May; 20(9):2837-42. PubMed ID: 20347593
[TBL] [Abstract][Full Text] [Related]
13. Macrocyclic statine-based inhibitors of BACE-1.
Barazza A; Götz M; Cadamuro SA; Goettig P; Willem M; Steuber H; Kohler T; Jestel A; Reinemer P; Renner C; Bode W; Moroder L
Chembiochem; 2007 Nov; 8(17):2078-91. PubMed ID: 17963207
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
Hu B; Fan KY; Bridges K; Chopra R; Lovering F; Cole D; Zhou P; Ellingboe J; Jin G; Cowling R; Bard J
Bioorg Med Chem Lett; 2004 Jul; 14(13):3457-60. PubMed ID: 15177452
[TBL] [Abstract][Full Text] [Related]
15. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Machauer R; Laumen K; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Jaton AL; Desrayaud S; Staufenbiel M; Rabe S; Paganetti P; Neumann U
Bioorg Med Chem Lett; 2009 Mar; 19(5):1366-70. PubMed ID: 19195887
[TBL] [Abstract][Full Text] [Related]
16. Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.
Huang Y; Strobel ED; Ho CY; Reynolds CH; Conway KA; Piesvaux JA; Brenneman DE; Yohrling GJ; Moore Arnold H; Rosenthal D; Alexander RS; Tounge BA; Mercken M; Vandermeeren M; Parker MH; Reitz AB; Baxter EW
Bioorg Med Chem Lett; 2010 May; 20(10):3158-60. PubMed ID: 20399652
[TBL] [Abstract][Full Text] [Related]
17. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
Wångsell F; Gustafsson K; Kvarnström I; Borkakoti N; Edlund M; Jansson K; Lindberg J; Hallberg A; Rosenquist A; Samuelsson B
Eur J Med Chem; 2010 Mar; 45(3):870-82. PubMed ID: 20036448
[TBL] [Abstract][Full Text] [Related]
18. Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bowers S; Xu YZ; Yuan S; Probst GD; Hom RK; Chan W; Konradi AW; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR
Bioorg Med Chem Lett; 2013 Apr; 23(7):2181-6. PubMed ID: 23465612
[TBL] [Abstract][Full Text] [Related]
19. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
Yang W; Lu W; Lu Y; Zhong M; Sun J; Thomas AE; Wilkinson JM; Fucini RV; Lam M; Randal M; Shi XP; Jacobs JW; McDowell RS; Gordon EM; Ballinger MD
J Med Chem; 2006 Feb; 49(3):839-42. PubMed ID: 16451048
[TBL] [Abstract][Full Text] [Related]
20. Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
Iserloh U; Pan J; Stamford AW; Kennedy ME; Zhang Q; Zhang L; Parker EM; McHugh NA; Favreau L; Strickland C; Voigt J
Bioorg Med Chem Lett; 2008 Jan; 18(1):418-22. PubMed ID: 17980584
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]