BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 18845790)

  • 1. The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.
    Boccalatte FE; Voena C; Riganti C; Bosia A; D'Amico L; Riera L; Cheng M; Ruggeri B; Jensen ON; Goss VL; Lee K; Nardone J; Rush J; Polakiewicz RD; Comb MJ; Chiarle R; Inghirami G
    Blood; 2009 Mar; 113(12):2776-90. PubMed ID: 18845790
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis.
    Ma Z; Cools J; Marynen P; Cui X; Siebert R; Gesk S; Schlegelberger B; Peeters B; De Wolf-Peeters C; Wlodarska I; Morris SW
    Blood; 2000 Mar; 95(6):2144-9. PubMed ID: 10706887
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
    Trinei M; Lanfrancone L; Campo E; Pulford K; Mason DY; Pelicci PG; Falini B
    Cancer Res; 2000 Feb; 60(4):793-8. PubMed ID: 10706082
    [TBL] [Abstract][Full Text] [Related]  

  • 4. ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
    Colleoni GW; Bridge JA; Garicochea B; Liu J; Filippa DA; Ladanyi M
    Am J Pathol; 2000 Mar; 156(3):781-9. PubMed ID: 10702393
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma.
    Wu F; Wang P; Zhang J; Young LC; Lai R; Li L
    Mol Cell Proteomics; 2010 Jul; 9(7):1616-32. PubMed ID: 20393185
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.
    Christensen JG; Zou HY; Arango ME; Li Q; Lee JH; McDonnell SR; Yamazaki S; Alton GR; Mroczkowski B; Los G
    Mol Cancer Ther; 2007 Dec; 6(12 Pt 1):3314-22. PubMed ID: 18089725
    [TBL] [Abstract][Full Text] [Related]  

  • 7. NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis.
    McDonnell SR; Hwang SR; Basrur V; Conlon KP; Fermin D; Wey E; Murga-Zamalloa C; Zeng Z; Zu Y; Elenitoba-Johnson KS; Lim MS
    Oncogene; 2012 Aug; 31(32):3733-40. PubMed ID: 22179823
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target.
    Werner MT; Zhao C; Zhang Q; Wasik MA
    Blood; 2017 Feb; 129(7):823-831. PubMed ID: 27879258
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
    Li M; Jin C; Xu M; Zhou L; Li D; Yin Y
    Cell Commun Signal; 2017 Dec; 15(1):52. PubMed ID: 29246230
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of ATIC as a Novel Target for Chemoradiosensitization.
    Liu X; Paila UD; Teraoka SN; Wright JA; Huang X; Quinlan AR; Gatti RA; Concannon P
    Int J Radiat Oncol Biol Phys; 2018 Jan; 100(1):162-173. PubMed ID: 29029884
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Silibinin suppresses NPM-ALK, potently induces apoptosis and enhances chemosensitivity in ALK-positive anaplastic large cell lymphoma.
    Molavi O; Samadi N; Wu C; Lavasanifar A; Lai R
    Leuk Lymphoma; 2016 May; 57(5):1154-62. PubMed ID: 26133723
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene.
    van der Krogt JA; Bempt MV; Ferreiro JF; Mentens N; Jacobs K; Pluys U; Doms K; Geerdens E; Uyttebroeck A; Pierre P; Michaux L; Devos T; Vandenberghe P; Tousseyn T; Cools J; Wlodarska I
    Haematologica; 2017 Sep; 102(9):1605-1616. PubMed ID: 28659337
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.
    Vergis JM; Bulock KG; Fleming KG; Beardsley GP
    J Biol Chem; 2001 Mar; 276(11):7727-33. PubMed ID: 11096114
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells.
    Wan W; Albom MS; Lu L; Quail MR; Becknell NC; Weinberg LR; Reddy DR; Holskin BP; Angeles TS; Underiner TL; Meyer SL; Hudkins RL; Dorsey BD; Ator MA; Ruggeri BA; Cheng M
    Blood; 2006 Feb; 107(4):1617-23. PubMed ID: 16254137
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.
    Le Nours J; Bulloch EM; Zhang Z; Greenwood DR; Middleditch MJ; Dickson JM; Baker EN
    J Biol Chem; 2011 Nov; 286(47):40706-16. PubMed ID: 21956117
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ALK kinase domain mutations in primary anaplastic large cell lymphoma: consequences on NPM-ALK activity and sensitivity to tyrosine kinase inhibitors.
    Lovisa F; Cozza G; Cristiani A; Cuzzolin A; Albiero A; Mussolin L; Pillon M; Moro S; Basso G; Rosolen A; Bonvini P
    PLoS One; 2015; 10(4):e0121378. PubMed ID: 25874976
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming.
    Marzec M; Halasa K; Liu X; Wang HY; Cheng M; Baldwin D; Tobias JW; Schuster SJ; Woetmann A; Zhang Q; Turner SD; Ødum N; Wasik MA
    J Immunol; 2013 Dec; 191(12):6200-7. PubMed ID: 24218456
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.
    Piva R; Pellegrino E; Mattioli M; Agnelli L; Lombardi L; Boccalatte F; Costa G; Ruggeri BA; Cheng M; Chiarle R; Palestro G; Neri A; Inghirami G
    J Clin Invest; 2006 Dec; 116(12):3171-82. PubMed ID: 17111047
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity.
    Cussac D; Greenland C; Roche S; Bai RY; Duyster J; Morris SW; Delsol G; Allouche M; Payrastre B
    Blood; 2004 Feb; 103(4):1464-71. PubMed ID: 14563642
    [TBL] [Abstract][Full Text] [Related]  

  • 20. ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival.
    Zhang H; Xia P; Liu J; Chen Z; Ma W; Yuan Y
    Int J Biol Sci; 2021; 17(15):4442-4458. PubMed ID: 34803509
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 8.