177 related articles for article (PubMed ID: 18847185)
1. Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
Hay MP; Hicks KO; Pchalek K; Lee HH; Blaser A; Pruijn FB; Anderson RF; Shinde SS; Wilson WR; Denny WA
J Med Chem; 2008 Nov; 51(21):6853-65. PubMed ID: 18847185
[TBL] [Abstract][Full Text] [Related]
2. New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides.
Amin KM; Ismail MM; Noaman E; Soliman DH; Ammar YA
Bioorg Med Chem; 2006 Oct; 14(20):6917-23. PubMed ID: 16843668
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as potential hypoxic cytotoxins and DNA-binders.
Cerecetto H; González M; Risso M; Seoane G; López de Ceráin A; Ezpeleta O; Monge A; Suescun L; Mombrú A; Bruno AM
Arch Pharm (Weinheim); 2000 Nov; 333(11):387-93. PubMed ID: 11129981
[TBL] [Abstract][Full Text] [Related]
4. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
Hay MP; Gamage SA; Kovacs MS; Pruijn FB; Anderson RF; Patterson AV; Wilson WR; Brown JM; Denny WA
J Med Chem; 2003 Jan; 46(1):169-82. PubMed ID: 12502371
[TBL] [Abstract][Full Text] [Related]
5. N-oxides as hypoxia selective cytotoxins.
Cerecetto H; González M
Mini Rev Med Chem; 2001 Sep; 1(3):219-31. PubMed ID: 12369969
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and biological activities of antiangiogenic hypoxic cytotoxin, triazine-N-oxide derivatives.
Nagasawa H; Yamashita M; Mikamo N; Shimamura M; Oka S; Uto Y; Hori H
Comp Biochem Physiol A Mol Integr Physiol; 2002 May; 132(1):33-40. PubMed ID: 12062188
[TBL] [Abstract][Full Text] [Related]
7. Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides.
Monge A; Palop JA; López de Ceráin A; Senador V; Martínez-Crespo FJ; Sainz Y; Narro S; García E; de Miguel C; González M
J Med Chem; 1995 May; 38(10):1786-92. PubMed ID: 7752202
[TBL] [Abstract][Full Text] [Related]
8. Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
Hay MP; Pchalek K; Pruijn FB; Hicks KO; Siim BG; Anderson RF; Shinde SS; Phillips V; Denny WA; Wilson WR
J Med Chem; 2007 Dec; 50(26):6654-64. PubMed ID: 18052317
[TBL] [Abstract][Full Text] [Related]
9. 1,2,4-Benzotriazine 1,4-dioxides. An important class of hypoxic cytotoxins with antitumor activity.
Kelson AB; McNamara JP; Pandey A; Ryan KJ; Dorie MJ; McAfee PA; Menke DR; Brown JM; Tracy M
Anticancer Drug Des; 1998 Sep; 13(6):575-92. PubMed ID: 9755719
[TBL] [Abstract][Full Text] [Related]
10. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
Lee HH; Wilson WR; Denny WA
Anticancer Drug Des; 1999 Dec; 14(6):487-97. PubMed ID: 10834270
[TBL] [Abstract][Full Text] [Related]
11. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
Hay MP; Pruijn FB; Gamage SA; Liyanage HD; Kovacs MS; Patterson AV; Wilson WR; Brown JM; Denny WA
J Med Chem; 2004 Jan; 47(2):475-88. PubMed ID: 14711317
[TBL] [Abstract][Full Text] [Related]
12. 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part II.
Cerecetto H; González M; Onetto S; Saenz P; Ezpeleta O; De Ceráin AL; Monge A
Arch Pharm (Weinheim); 2004 May; 337(5):247-58. PubMed ID: 15095418
[TBL] [Abstract][Full Text] [Related]
13. Structural modifications on the phenazine N,N'-dioxide-scaffold looking for new selective hypoxic cytotoxins.
Lavaggi ML; Nieves M; Cabrera M; Olea-Azar C; López de Ceráin A; Monge A; Cerecetto H; González M
Eur J Med Chem; 2010 Nov; 45(11):5362-9. PubMed ID: 20846761
[TBL] [Abstract][Full Text] [Related]
14. 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part III.
Cerecetto H; González M; Risso M; Saenz P; Olea-Azar C; Bruno AM; Azqueta A; De Ceráin AL; Monge A
Arch Pharm (Weinheim); 2004 May; 337(5):271-80. PubMed ID: 15095420
[TBL] [Abstract][Full Text] [Related]
15. Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs).
Elsaidi HR; Yang XH; Ahmadi F; Weinfeld M; Wiebe LI; Kumar P
Eur J Med Chem; 2019 Mar; 165():216-224. PubMed ID: 30684798
[TBL] [Abstract][Full Text] [Related]
16. Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
Hay MP; Hicks KO; Pruijn FB; Pchalek K; Siim BG; Wilson WR; Denny WA
J Med Chem; 2007 Dec; 50(25):6392-404. PubMed ID: 18001018
[TBL] [Abstract][Full Text] [Related]
17. Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives.
Vieites M; Noblía P; Torre MH; Cerecetto H; Laura Lavaggi M; Costa-Filho AJ; Azqueta A; de Cerain AL; Monge A; Parajón-Costa B; González M; Gambino D
J Inorg Biochem; 2006 Aug; 100(8):1358-67. PubMed ID: 16698084
[TBL] [Abstract][Full Text] [Related]
18. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins.
Cerecetto H; González M; Lavaggi ML; Azqueta A; López de Cerain A; Monge A
J Med Chem; 2005 Jan; 48(1):21-3. PubMed ID: 15633996
[TBL] [Abstract][Full Text] [Related]
19. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies.
Cerecetto H; González M; Lavaggi ML; Aravena MA; Rigol C; Olea-Azar C; Azqueta A; de Cerain AL; Monge A; Bruno AM
Med Chem; 2006 Sep; 2(5):511-21. PubMed ID: 17017991
[TBL] [Abstract][Full Text] [Related]
20. Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs.
Siim BG; Atwell GJ; Anderson RF; Wardman P; Pullen SM; Wilson WR; Denny WA
J Med Chem; 1997 Apr; 40(9):1381-90. PubMed ID: 9135035
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]