These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

255 related articles for article (PubMed ID: 18854490)

  • 21. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease.
    Zetterberg H; Andreasson U; Hansson O; Wu G; Sankaranarayanan S; Andersson ME; Buchhave P; Londos E; Umek RM; Minthon L; Simon AJ; Blennow K
    Arch Neurol; 2008 Aug; 65(8):1102-7. PubMed ID: 18695061
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
    Pietrak BL; Crouthamel MC; Tugusheva K; Lineberger JE; Xu M; DiMuzio JM; Steele T; Espeseth AS; Stachel SJ; Coburn CA; Graham SL; Vacca JP; Shi XP; Simon AJ; Hazuda DJ; Lai MT
    Anal Biochem; 2005 Jul; 342(1):144-51. PubMed ID: 15958191
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice.
    Lanz TA; Himes CS; Pallante G; Adams L; Yamazaki S; Amore B; Merchant KM
    J Pharmacol Exp Ther; 2003 Jun; 305(3):864-71. PubMed ID: 12626636
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys.
    Tang C; Kuo Y; Pudvah NT; Ellis JD; Michener MS; Egbertson M; Graham SL; Cook JJ; Hochman JH; Prueksaritanont T
    Biochem Pharmacol; 2009 Sep; 78(6):642-7. PubMed ID: 19481060
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1.
    Kakizawa T; Hidaka K; Hamada D; Yamaguchi R; Uemura T; Kitamura H; Tagad HD; Hamada T; Ziora Z; Hamada Y; Kimura T; Kiso Y
    J Pept Sci; 2010 Jun; 16(6):257-62. PubMed ID: 20474036
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.
    Rueeger H; Lueoend R; Rogel O; Rondeau JM; Möbitz H; Machauer R; Jacobson L; Staufenbiel M; Desrayaud S; Neumann U
    J Med Chem; 2012 Apr; 55(7):3364-86. PubMed ID: 22380629
    [TBL] [Abstract][Full Text] [Related]  

  • 27. [3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.
    Iben LG; Kopcho L; Marcinkeviciene J; Zheng C; Thompson LA; Albright CF; Toyn JH
    Eur J Pharmacol; 2008 Sep; 593(1-3):10-5. PubMed ID: 18655784
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Modeling effect of a γ-secretase inhibitor on amyloid-β dynamics reveals significant role of an amyloid clearance mechanism.
    Das R; Nachbar RB; Edelstein-Keshet L; Saltzman JS; Wiener MC; Bagchi A; Bailey J; Coombs D; Simon AJ; Hargreaves RJ; Cook JJ
    Bull Math Biol; 2011 Jan; 73(1):230-47. PubMed ID: 20411345
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
    Lerchner A; Machauer R; Betschart C; Veenstra S; Rueeger H; McCarthy C; Tintelnot-Blomley M; Jaton AL; Rabe S; Desrayaud S; Enz A; Staufenbiel M; Paganetti P; Rondeau JM; Neumann U
    Bioorg Med Chem Lett; 2010 Jan; 20(2):603-7. PubMed ID: 19963375
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).
    Lanz TA; Hosley JD; Adams WJ; Merchant KM
    J Pharmacol Exp Ther; 2004 Apr; 309(1):49-55. PubMed ID: 14718585
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Systems Pharmacology Analysis of the Amyloid Cascade after β-Secretase Inhibition Enables the Identification of an Aβ42 Oligomer Pool.
    van Maanen EM; van Steeg TJ; Michener MS; Savage MJ; Kennedy ME; Kleijn HJ; Stone JA; Danhof M
    J Pharmacol Exp Ther; 2016 Apr; 357(1):205-16. PubMed ID: 26826190
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.
    Weiss MM; Williamson T; Babu-Khan S; Bartberger MD; Brown J; Chen K; Cheng Y; Citron M; Croghan MD; Dineen TA; Esmay J; Graceffa RF; Harried SS; Hickman D; Hitchcock SA; Horne DB; Huang H; Imbeah-Ampiah R; Judd T; Kaller MR; Kreiman CR; La DS; Li V; Lopez P; Louie S; Monenschein H; Nguyen TT; Pennington LD; Rattan C; San Miguel T; Sickmier EA; Wahl RC; Wen PH; Wood S; Xue Q; Yang BH; Patel VF; Zhong W
    J Med Chem; 2012 Nov; 55(21):9009-24. PubMed ID: 22468639
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Cisterna magna cannulated repeated CSF sampling rat model--effects of a gamma-secretase inhibitor on Aβ levels.
    Shapiro JS; Stiteler M; Wu G; Price EA; Simon AJ; Sankaranarayanan S
    J Neurosci Methods; 2012 Mar; 205(1):36-44. PubMed ID: 22226743
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors.
    Malamas MS; Erdei J; Gunawan I; Turner J; Hu Y; Wagner E; Fan K; Chopra R; Olland A; Bard J; Jacobsen S; Magolda RL; Pangalos M; Robichaud AJ
    J Med Chem; 2010 Feb; 53(3):1146-58. PubMed ID: 19968289
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition.
    Schelle J; Häsler LM; Göpfert JC; Joos TO; Vanderstichele H; Stoops E; Mandelkow EM; Neumann U; Shimshek DR; Staufenbiel M; Jucker M; Kaeser SA
    Alzheimers Dement; 2017 Jun; 13(6):701-709. PubMed ID: 27750032
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects.
    Wu G; Sankaranarayanan S; Tugusheva K; Kahana J; Seabrook G; Shi XP; King E; Devanarayan V; Cook JJ; Simon AJ
    Clin Biochem; 2008 Aug; 41(12):986-96. PubMed ID: 18489907
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Progress toward the discovery and development of efficacious BACE inhibitors.
    Durham TB; Shepherd TA
    Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid.
    Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K
    Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Progress toward a practical BACE-1 inhibitor.
    Hills ID; Vacca JP
    Curr Opin Drug Discov Devel; 2007 Jul; 10(4):383-91. PubMed ID: 17659479
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B; Pereira I; Parkin E
    Brain Res; 2009 Nov; 1296():203-15. PubMed ID: 19679113
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.