BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1570 related articles for article (PubMed ID: 18925875)

  • 1. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
    García-Martínez JM; Alessi DR
    Biochem J; 2008 Dec; 416(3):375-85. PubMed ID: 18925875
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
    Pearce LR; Sommer EM; Sakamoto K; Wullschleger S; Alessi DR
    Biochem J; 2011 May; 436(1):169-79. PubMed ID: 21413931
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
    García-Martínez JM; Moran J; Clarke RG; Gray A; Cosulich SC; Chresta CM; Alessi DR
    Biochem J; 2009 Jun; 421(1):29-42. PubMed ID: 19402821
    [TBL] [Abstract][Full Text] [Related]  

  • 4. mTORC2 is the hydrophobic motif kinase for SGK1.
    Yan L; Mieulet V; Lamb RF
    Biochem J; 2008 Dec; 416(3):e19-21. PubMed ID: 19025518
    [TBL] [Abstract][Full Text] [Related]  

  • 5. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
    Julien LA; Carriere A; Moreau J; Roux PP
    Mol Cell Biol; 2010 Feb; 30(4):908-21. PubMed ID: 19995915
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of rictor as a novel substrate of Polo-like kinase 1.
    Shao T; Liu X
    Cell Cycle; 2015; 14(5):755-60. PubMed ID: 25714006
    [TBL] [Abstract][Full Text] [Related]  

  • 7. mTOR complex-2 activates ENaC by phosphorylating SGK1.
    Lu M; Wang J; Jones KT; Ives HE; Feldman ME; Yao LJ; Shokat KM; Ashrafi K; Pearce D
    J Am Soc Nephrol; 2010 May; 21(5):811-8. PubMed ID: 20338997
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
    Pearce LR; Huang X; Boudeau J; Pawłowski R; Wullschleger S; Deak M; Ibrahim AF; Gourlay R; Magnuson MA; Alessi DR
    Biochem J; 2007 Aug; 405(3):513-22. PubMed ID: 17461779
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
    Collins BJ; Deak M; Murray-Tait V; Storey KG; Alessi DR
    J Cell Sci; 2005 Nov; 118(Pt 21):5023-34. PubMed ID: 16219676
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression.
    Hall BA; Kim TY; Skor MN; Conzen SD
    Breast Cancer Res Treat; 2012 Sep; 135(2):469-79. PubMed ID: 22842983
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
    Gao D; Wan L; Inuzuka H; Berg AH; Tseng A; Zhai B; Shaik S; Bennett E; Tron AE; Gasser JA; Lau A; Gygi SP; Harper JW; DeCaprio JA; Toker A; Wei W
    Mol Cell; 2010 Sep; 39(5):797-808. PubMed ID: 20832730
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase.
    Mori S; Nada S; Kimura H; Tajima S; Takahashi Y; Kitamura A; Oneyama C; Okada M
    PLoS One; 2014; 9(2):e88891. PubMed ID: 24558442
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
    Yu Z; Chen J; Takagi E; Wang F; Saha B; Liu X; Joubert LM; Gleason CE; Jin M; Li C; Nowotny C; Agard D; Cheng Y; Pearce D
    J Biol Chem; 2022 Sep; 298(9):102288. PubMed ID: 35926713
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
    Lizcano JM; Deak M; Morrice N; Kieloch A; Hastie CJ; Dong L; Schutkowski M; Reimer U; Alessi DR
    J Biol Chem; 2002 Aug; 277(31):27839-49. PubMed ID: 12023960
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1.
    Gao D; Wan L; Wei W
    Protein Cell; 2010 Oct; 1(10):881-5. PubMed ID: 21204013
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
    Gulati N; Karsy M; Albert L; Murali R; Jhanwar-Uniyal M
    Int J Oncol; 2009 Oct; 35(4):731-40. PubMed ID: 19724909
    [TBL] [Abstract][Full Text] [Related]  

  • 17. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
    Lu M; Wang J; Ives HE; Pearce D
    J Biol Chem; 2011 Sep; 286(35):30647-30654. PubMed ID: 21757730
    [TBL] [Abstract][Full Text] [Related]  

  • 18. mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.
    Yin Y; Hua H; Li M; Liu S; Kong Q; Shao T; Wang J; Luo Y; Wang Q; Luo T; Jiang Y
    Cell Res; 2016 Jan; 26(1):46-65. PubMed ID: 26584640
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy.
    Das F; Ghosh-Choudhury N; Mariappan MM; Kasinath BS; Choudhury GG
    Am J Physiol Cell Physiol; 2016 Apr; 310(7):C583-96. PubMed ID: 26739493
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.
    Saha B; Shabbir W; Takagi E; Duan XP; Leite Dellova DCA; Demko J; Manis A; Loffing-Cueni D; Loffing J; Sørensen MV; Wang WH; Pearce D
    J Am Soc Nephrol; 2023 Jun; 34(6):1019-1038. PubMed ID: 36890646
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 79.