BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 18931375)

  • 1. The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions.
    Jia L; Geacintov NE; Broyde S
    Nucleic Acids Res; 2008 Nov; 36(20):6571-84. PubMed ID: 18931375
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications.
    Chandani S; Loechler EL
    J Mol Graph Model; 2009 Apr; 27(7):759-69. PubMed ID: 19188081
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches.
    Perlow-Poehnelt RA; Likhterov I; Scicchitano DA; Geacintov NE; Broyde S
    J Biol Chem; 2004 Aug; 279(35):36951-61. PubMed ID: 15210693
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Influence of local sequence context on damaged base conformation in human DNA polymerase iota: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion.
    Donny-Clark K; Broyde S
    Nucleic Acids Res; 2009 Nov; 37(21):7095-109. PubMed ID: 19767609
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Extending the understanding of mutagenicity: structural insights into primer-extension past a benzo[a]pyrene diol epoxide-DNA adduct.
    Perlow RA; Broyde S
    J Mol Biol; 2003 Apr; 327(4):797-818. PubMed ID: 12654264
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.
    Lior-Hoffmann L; Wang L; Wang S; Geacintov NE; Broyde S; Zhang Y
    Nucleic Acids Res; 2012 Oct; 40(18):9193-205. PubMed ID: 22772988
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity.
    Lior-Hoffmann L; Ding S; Geacintov NE; Zhang Y; Broyde S
    Biochemistry; 2014 Sep; 53(35):5683-91. PubMed ID: 25148552
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.
    Jha V; Bian C; Xing G; Ling H
    Nucleic Acids Res; 2016 Jun; 44(10):4957-67. PubMed ID: 27034468
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment.
    Bauer J; Xing G; Yagi H; Sayer JM; Jerina DM; Ling H
    Proc Natl Acad Sci U S A; 2007 Sep; 104(38):14905-10. PubMed ID: 17848527
    [TBL] [Abstract][Full Text] [Related]  

  • 10. trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.
    Rechkoblit O; Zhang Y; Guo D; Wang Z; Amin S; Krzeminsky J; Louneva N; Geacintov NE
    J Biol Chem; 2002 Aug; 277(34):30488-94. PubMed ID: 12063247
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.
    Xu P; Oum L; Lee YC; Geacintov NE; Broyde S
    Biochemistry; 2009 Jun; 48(22):4677-90. PubMed ID: 19364137
    [TBL] [Abstract][Full Text] [Related]  

  • 12. How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene.
    Sholder G; Creech A; Loechler EL
    DNA Repair (Amst); 2015 Nov; 35():144-53. PubMed ID: 26523515
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
    Xu P; Oum L; Beese LS; Geacintov NE; Broyde S
    Nucleic Acids Res; 2007; 35(13):4275-88. PubMed ID: 17576677
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa.
    Sassa A; Niimi N; Fujimoto H; Katafuchi A; Grúz P; Yasui M; Gupta RC; Johnson F; Ohta T; Nohmi T
    Mutat Res; 2011 Jan; 718(1-2):10-7. PubMed ID: 21078407
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct.
    Liu Y; Ma X; Guo C
    J Biochem; 2016 Apr; 159(4):471-9. PubMed ID: 26634445
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of base sequence context on translesion synthesis past a bulky (+)-trans-anti-B[a]P-N2-dG lesion catalyzed by the Y-family polymerase pol kappa.
    Huang X; Kolbanovskiy A; Wu X; Zhang Y; Wang Z; Zhuang P; Amin S; Geacintov NE
    Biochemistry; 2003 Mar; 42(8):2456-66. PubMed ID: 12600213
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evading the proofreading machinery of a replicative DNA polymerase: induction of a mutation by an environmental carcinogen.
    Perlow RA; Broyde S
    J Mol Biol; 2001 Jun; 309(2):519-36. PubMed ID: 11371169
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism.
    Xu P; Oum L; Geacintov NE; Broyde S
    Biochemistry; 2008 Mar; 47(9):2701-9. PubMed ID: 18260644
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences.
    Perlow RA; Broyde S
    J Mol Biol; 2002 Sep; 322(2):291-309. PubMed ID: 12217692
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A method to accurately quantitate intensities of (32)P-DNA bands when multiple bands appear in a single lane of a gel is used to study dNTP insertion opposite a benzo[a]pyrene-dG adduct by Sulfolobus DNA polymerases Dpo4 and Dbh.
    Sholder G; Loechler EL
    DNA Repair (Amst); 2015 Jan; 25():97-103. PubMed ID: 25497330
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.