143 related articles for article (PubMed ID: 18936111)
1. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.
Qin Z; Kastrati I; Ashgodom RT; Lantvit DD; Overk CR; Choi Y; van Breemen RB; Bolton JL; Thatcher GR
Drug Metab Dispos; 2009 Jan; 37(1):161-9. PubMed ID: 18936111
[TBL] [Abstract][Full Text] [Related]
2. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Liu H; Qin Z; Thatcher GR; Bolton JL
Chem Res Toxicol; 2007 Nov; 20(11):1676-84. PubMed ID: 17630709
[TBL] [Abstract][Full Text] [Related]
3. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
Liu H; Bolton JL; Thatcher GR
Chem Res Toxicol; 2006 Jun; 19(6):779-87. PubMed ID: 16780356
[TBL] [Abstract][Full Text] [Related]
4. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Yu B; Dietz BM; Dunlap T; Kastrati I; Lantvit DD; Overk CR; Yao P; Qin Z; Bolton JL; Thatcher GR
Mol Cancer Ther; 2007 Sep; 6(9):2418-28. PubMed ID: 17876041
[TBL] [Abstract][Full Text] [Related]
5. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Liu H; Liu J; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):162-73. PubMed ID: 15720120
[TBL] [Abstract][Full Text] [Related]
6. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
Overk CR; Peng KW; Asghodom RT; Kastrati I; Lantvit DD; Qin Z; Frasor J; Bolton JL; Thatcher GR
ChemMedChem; 2007 Oct; 2(10):1520-6. PubMed ID: 17654759
[TBL] [Abstract][Full Text] [Related]
7. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.
Qin Z; Kastrati I; Chandrasena RE; Liu H; Yao P; Petukhov PA; Bolton JL; Thatcher GR
J Med Chem; 2007 May; 50(11):2682-92. PubMed ID: 17489582
[TBL] [Abstract][Full Text] [Related]
8. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol.
Michalsen BT; Gherezghiher TB; Choi J; Chandrasena RE; Qin Z; Thatcher GR; Bolton JL
Chem Res Toxicol; 2012 Jul; 25(7):1472-83. PubMed ID: 22642258
[TBL] [Abstract][Full Text] [Related]
9. On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators.
van Liempd SM; Kool J; Niessen WM; van Elswijk DE; Irth H; Vermeulen NP
Drug Metab Dispos; 2006 Sep; 34(9):1640-9. PubMed ID: 16790557
[TBL] [Abstract][Full Text] [Related]
10. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.
Gherezghiher TB; Michalsen B; Chandrasena RE; Qin Z; Sohn J; Thatcher GR; Bolton JL
Chem Biol Interact; 2012 Mar; 196(1-2):1-10. PubMed ID: 22290292
[TBL] [Abstract][Full Text] [Related]
11. Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.
Toader V; Xu X; Nicolescu A; Yu L; Bolton JL; Thatcher GR
Chem Res Toxicol; 2003 Oct; 16(10):1264-76. PubMed ID: 14565768
[TBL] [Abstract][Full Text] [Related]
12. Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Chen Q; Ngui JS; Doss GA; Wang RW; Cai X; DiNinno FP; Blizzard TA; Hammond ML; Stearns RA; Evans DC; Baillie TA; Tang W
Chem Res Toxicol; 2002 Jul; 15(7):907-14. PubMed ID: 12119000
[TBL] [Abstract][Full Text] [Related]
13. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
Kastrati I; Edirisinghe PD; Hemachandra LP; Chandrasena ER; Choi J; Wang YT; Bolton JL; Thatcher GR
PLoS One; 2011; 6(11):e27876. PubMed ID: 22140478
[TBL] [Abstract][Full Text] [Related]
14. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.
Yu L; Liu H; Li W; Zhang F; Luckie C; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2004 Jul; 17(7):879-88. PubMed ID: 15257612
[TBL] [Abstract][Full Text] [Related]
15. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Liu J; Liu H; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):174-82. PubMed ID: 15720121
[TBL] [Abstract][Full Text] [Related]
16. In vitro metabolic fate of a novel structural class: evidence for the formation of a reactive intermediate on a benzothiophene moiety.
Evans CA; Fries HE; Ward KW
Chem Biol Interact; 2005 Feb; 152(1):25-36. PubMed ID: 15766920
[TBL] [Abstract][Full Text] [Related]
17. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
Yu B; Qin Z; Wijewickrama GT; Edirisinghe P; Bolton JL; Thatcher GR
Bioconjug Chem; 2009 Apr; 20(4):728-41. PubMed ID: 19301905
[TBL] [Abstract][Full Text] [Related]
18. Benzothiophene and naphthalene derived constrained SERMs.
Wallace OB; Bryant HU; Shetler PK; Adrian MD; Geiser AG
Bioorg Med Chem Lett; 2004 Oct; 14(20):5103-6. PubMed ID: 15380208
[TBL] [Abstract][Full Text] [Related]
19. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.
Liu J; Li Q; Yang X; van Breemen RB; Bolton JL; Thatcher GR
Chem Res Toxicol; 2005 Sep; 18(9):1485-96. PubMed ID: 16167842
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites.
Bansal S; Lau AJ
J Pharmacol Exp Ther; 2019 Jun; 369(3):389-405. PubMed ID: 30918069
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
